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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	D0V8NS
Molecular formula	C25H30N2O3
IUPAC name	2-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-4,4-dimethylnaphthalene-1,3-dione
Molecular weight	406.526
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.2
Synonyms	GTPL524 CAS_122211 NSC_122211 2-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-4,4-dimethyl-1,2,3,4-tetrahydronaphthalene-1,3-dione BDBM81772
Inchi Key	OSEADGVOKYGIER-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H30N2O3/c1-25(2)20-9-5-4-8-18(20)23(28)19(24(25)29)12-13-26-14-16-27(17-15-26)21-10-6-7-11-22(21)30-3/h4-11,19H,12-17H2,1-3H3
PubChem CID	122211
ChEMBL	N/A
IUPHAR	524
BindingDB	81772
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
249098	Alpha-2A adrenergic receptor	Q28838	ADRA2A	Bos taurus (Bovine)	452
249100	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
249104	Alpha-2A adrenergic receptor	P22909	Adra2a	Rattus norvegicus (Rat)	450
249106	Alpha-2A adrenergic receptor	P18871	ADRA2A	Sus scrofa (Pig)	450
249097	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
249099	Alpha-2B adrenergic receptor	O77830	ADRA2B	Oryctolagus cuniculus (Rabbit)	394
249103	Alpha-2B adrenergic receptor	O77715	ADRA2B	Didelphis virginiana (North American opossum)	382
249107	Alpha-2B adrenergic receptor	P19328	Adra2b	Rattus norvegicus (Rat)	453
249101	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
249102	Alpha-2C adrenergic receptor	P35405	ADRA2C	Didelphis virginiana (North American opossum)	469
249108	Alpha-2C adrenergic receptor	P22086	Adra2c	Rattus norvegicus (Rat)	458

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