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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Diprenorphine
Molecular formula	C26H35NO4
IUPAC name	(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-(2-hydroxypropan-2-yl)-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Molecular weight	425.569
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.6
Synonyms	14357-78-9 21-Cyclopropyl-6,7,8,14-tetrahydro-7alpha-(1-hydroxy-1-methylethyl)-6,14-endo-ethanooripavine API0004768 Diprenorphine [INN:BAN] M 5050 Injection 17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-?,?-dimethyl-6,14-ethenomorphinan-7-methanol 6,14-ethenomorphinan-3-ol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-18-(1-hydroxy-1-methylethyl)-6-methoxy-, (5alpha,6beta,14beta,18R)- CHEBI:4650 Diprenorfin Diprenorphinum [INN-Latin] M50-50 Injection (5?,7?)-17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-?,?-dimethyl-6,14-ethenomorphinan-7-methanol 2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2R,6S,14R,15R,16R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-2-propanol(diprenorphine) AC1L9ELZ D07863 GTPL1617 UNII-1F0L5N25ZZ BDBM50001714 DB01548 DIPRENORPHINE-HCl M. 5050 1F0L5N25ZZ 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,alpha-dimethyl-, (5alpha,7alpha)- Diprenorfina EINECS 238-325-7 RX 5050M (5alpha,7alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,alpha-dimethyl-6,14-ethenomorphinan-7-methanol 2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7(12),8,10-trien-16-yl]-2-propanol AKOS024457358 D0O6SB Diprenorphine (INN) M 5050 ZINC4102215 16808-86-9 (hydrochloride) 6,14-endo-Ethanotetrahydrooripavine, 21-cyclopropyl-7a-(1-hydroxy-1-methylethyl)- (8CI) 1-N-Cyclopropylmethyl-6,7,8,14-tetrahydro-6,14-endoethano-7-(2'-hydroxy-2'-propyl)nororipavine C11794 DEA No. 9058 Diprenorphinum M50-50 2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2R,6S,14R,15R,16R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-2-propanol 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,alpha-dimethyl-, (5alpha,7alpha)- (9CI) CHEMBL281786 Diprenorfina [INN-Spanish] epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,alpha-dimethyl-, (5alpha,7alpha)- SCHEMBL164910 [ Show all ]
Inchi Key	OIJXLIIMXHRJJH-KNLIIKEYSA-N
Inchi ID	InChI=1S/C26H35NO4/c1-23(2,29)18-13-24-8-9-26(18,30-3)22-25(24)10-11-27(14-15-4-5-15)19(24)12-16-6-7-17(28)21(31-22)20(16)25/h6-7,15,18-19,22,28-29H,4-5,8-14H2,1-3H3/t18-,19-,22-,24-,25+,26-/m1/s1
PubChem CID	443408
ChEMBL	CHEMBL281786
IUPHAR	1617
BindingDB	50001714
DrugBank	DB01548
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
242101	Delta-type opioid receptor	P41143	OPRD1	Homo sapiens (Human)	372
242106	Delta-type opioid receptor	P33533	Oprd1	Rattus norvegicus (Rat)	372
461298	Delta-type opioid receptor	P79291	OPRD1	Sus scrofa (Pig)	228
242103	Kappa-type opioid receptor	P41145	OPRK1	Homo sapiens (Human)	380
242105	Kappa-type opioid receptor	P34975	Oprk1	Rattus norvegicus (Rat)	380
242108	Kappa-type opioid receptor	P41144	OPRK1	Cavia porcellus (Guinea pig)	380
242102	Mu-type opioid receptor	P97266	OPRM1	Cavia porcellus (Guinea pig)	98
242104	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400
242107	Mu-type opioid receptor	P79350	OPRM1	Bos taurus (Bovine)	401
554471	Mu-type opioid receptor	P42866	Oprm1	Mus musculus (Mouse)	398

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