Online Services

●I-TASSER ●D-I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●D-QUARK ●DRfold ●DRfold2 ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred ●TCRfinder

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●DeepMSA2 ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 1
Species	Homo sapiens (Human)
Gene	GABBR1
Synonym	GPRC3A Gb1 gamma-aminobutyric acid (GABA) B receptor 1 gamma-aminobutyric acid (GABA) B receptor GABABR1 GABAB1 GABA-BR1 GABA-B-R1 GABA-B receptor 1 [ Show all ]
Disease	N/A
Length	961
Amino acid sequence	MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK
UniProt	Q9UBS5
Protein Data Bank	4mqe, 4mqf, 4mr9, 4mrm, 4ms1, 4ms3, 4ms4
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mqe.
BioLiP	BL0264367, BL0264359, BL0264358, BL0264357, BL0264356, BL0264366, BL0264368, BL0264369, BL0264370, BL0264371, BL0264365
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2064
IUPHAR	240
DrugBank	BE0000217

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
17146	CHEMBL2440659	C15H11FN4O2S	330.337	7 / 1	2.4	Yes
32233	4-aminobutyric acid	C4H9NO2	103.121	3 / 2	-3.2	Yes
46970	CHEMBL445449	C6H12NO2P	161.141	3 / 2	-3.5	Yes
46971	CHEMBL504482	C6H12NO2P	161.141	3 / 2	-3.5	Yes
46972	CHEMBL447171	C6H12NO2P	161.141	3 / 2	-3.5	Yes
62390	CHEMBL453966	C7H14NO2P	175.168	3 / 2	-3.2	Yes
96606	CHEMBL507116	C8H16NO2P	189.195	3 / 2	-2.7	Yes
123874	CHEMBL1939222	C10H8Cl2N2O2	259.086	3 / 2	2.5	Yes
556007	Abt-418	C9H14N2O	166.224	3 / 0	1.2	Yes
157581	ML315	C18H13Cl2N3O2	374.221	5 / 1	4.7	Yes
549939	Arbaclofen placarbil	C19H26ClNO6	399.868	6 / 2	4.2	Yes
550092	(R)-Baclofen	C10H12ClNO2	213.661	3 / 2	-1.0	Yes
175258	baclofen	C10H12ClNO2	213.661	3 / 2	-1.0	Yes
526991	CHEMBL3763166	C14H12BrN3O3S	382.232	5 / 3	2.3	Yes
550267	UNII-6XN50U405Y	C13H23N5O3	297.359	7 / 4	N/A	N/A
204393	TPMPA	C6H12NO2P	161.141	3 / 2	-3.5	Yes
550919	Cgp-36742	C7H18NO2P	179.2	3 / 2	-2.7	Yes
261050	CID 25202592	C6H11NO2	129.159	2 / 1	-1.5	Yes
452071	CHEMBL3310802	C27H39N5O7	545.637	9 / 2	N/A	No
556788	SCHEMBL1432281	C29H34ClN3O	476.061	2 / 1	7.4	No
554910	CGP-47656	C4H10F2NO2P	173.1	5 / 2	-3.0	Yes
552086	gabapentin	C9H17NO2	171.24	3 / 2	-1.1	Yes
370247	CHEMBL486434	C9H18NO2P	203.222	3 / 2	-2.3	Yes
370248	SCHEMBL3894140	C9H18NO2P	203.222	3 / 2	-2.3	Yes
370249	CHEMBL507241	C9H18NO2P	203.222	3 / 2	-2.3	Yes
378144	CHEMBL487279	C12H16NO2P	237.239	3 / 2	-2.0	Yes
557123	A-85380	C9H12N2O	164.208	3 / 1	0.6	Yes
552771	taurine	C2H7NO3S	125.142	4 / 2	-4.1	Yes
434813	CGP 54626 HYDROCHLORIDE	C18H29Cl3NO3P	444.758	4 / 4	N/A	N/A

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417