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GLASS

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GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 1
Species	Homo sapiens (Human)
Gene	GABBR1
Synonym	GPRC3A Gb1 gamma-aminobutyric acid (GABA) B receptor 1 gamma-aminobutyric acid (GABA) B receptor GABABR1 GABAB1 GABA-BR1 GABA-B-R1 GABA-B receptor 1 [ Show all ]
Disease	N/A
Length	961
Amino acid sequence	MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK
UniProt	Q9UBS5
Protein Data Bank	4mqe, 4mqf, 4mr9, 4mrm, 4ms1, 4ms3, 4ms4
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mqe.
BioLiP	BL0264367, BL0264359, BL0264358, BL0264357, BL0264356, BL0264366, BL0264368, BL0264369, BL0264370, BL0264371, BL0264365
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2064
IUPHAR	240
DrugBank	BE0000217

Ligand

Name	TPMPA
Molecular formula	C6H12NO2P
IUPAC name	methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid
Molecular weight	161.141
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-3.5
Synonyms	182485-36-5 P-Methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)phosphinic acid TR7I0800L2 AKOS006344745 J-011675 SCHEMBL678239 (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid Biomol-NT_000236 MolPort-003-959-683 CHEMBL397209 Phosphinic acid, P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)- UNII-TR7I0800L2 B6562 methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid SR-01000075623 (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinsaure BPBio1_000464 NCGC00163284-01 Tpmpa [MI] AC1L1KJ2 CTK7B4413 RT-016053 ZINC25720700 BDBM50211642 Methyl(1,2,3,6-tetrahydropyridinium-4-yl)phosphinate SR-01000075623-1 [ Show all ]
Inchi Key	MFUKVPOVVKKLRQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H12NO2P/c1-10(8,9)6-2-4-7-5-3-6/h2,7H,3-5H2,1H3,(H,8,9)
PubChem CID	5521
ChEMBL	CHEMBL397209
IUPHAR	N/A
BindingDB	50211642
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	500000.0 nM	PMID18528996	BindingDB,ChEMBL

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