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GPCR

NameGamma-aminobutyric acid type B receptor subunit 1
SpeciesHomo sapiens (Human)
GeneGABBR1
SynonymGPRC3A
Gb1
gamma-aminobutyric acid (GABA) B receptor 1
gamma-aminobutyric acid (GABA) B receptor
GABABR1
[ Show all ]
DiseaseN/A
Length961
Amino acid sequenceMLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK
UniProtQ9UBS5
Protein Data Bank4mqe, 4mqf, 4mr9, 4mrm, 4ms1, 4ms3, 4ms4
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4mqe.
BioLiPBL0264367, BL0264359, BL0264358, BL0264357, BL0264356, BL0264366, BL0264368, BL0264369, BL0264370, BL0264371, BL0264365
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2064
IUPHAR240
DrugBankBE0000217

Ligand

NameCHEMBL487279
Molecular formulaC12H16NO2P
IUPAC name(4-aminocyclopenten-1-yl)-benzylphosphinic acid
Molecular weight237.239
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP-2.0
SynonymsSCHEMBL3898966
Inchi KeyWOAYWNXXVWYVCK-UHFFFAOYSA-N
Inchi IDInChI=1S/C12H16NO2P/c13-11-6-7-12(8-11)16(14,15)9-10-4-2-1-3-5-10/h1-5,7,11H,6,8-9,13H2,(H,14,15)
PubChem CID24895103
ChEMBLCHEMBL487279
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition9.8 %PMID18528996ChEMBL

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