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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	(S)-PIA
Molecular formula	C19H23N5O4
IUPAC name	(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(2S)-1-phenylpropan-2-yl]amino]purin-9-yl]oxolane-3,4-diol
Molecular weight	385.424
Hydrogen bond acceptor	8
Hydrogen bond donor	4
XlogP	2.0
Synonyms	S-PIA (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(2S)-1-phenylpropan-2-yl]amino]purin-9-yl]oxolane-3,4-diol AC1NSM10 N6-(D-2-Phenylisopropyl)adenosine PDSP1_000298 CHEMBL420705 PDSP2_001015 GTPL415 SCHEMBL6762494 (2R,3S,4R,5R)-2-Hydroxymethyl-5-[6-((S)-1-methyl-2-phenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol BDBM50080398 N6-[(S)-1-Methyl-2-phenylethyl]ado (S-PIA) PDSP1_001031 2-Hydroxymethyl-5-[6-(1-methyl-2-phenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol CTK1C3340 S(+)-N6-(2-PHENYLISOPROPYL)ADENOSINE (S( +)-PIA) (+)-N6-(2-Phenylisopropyl)adenosine N6-((S)-1-Methyl-2-phenylethyl)adenosine ZINC1320081 (S)-N6-(1-Methyl-2-phenylethyl)adenosine NCGC00163299-01 PDSP2_000296 38594-97-7 D0E9QX [ Show all ]
Inchi Key	RIRGCFBBHQEQQH-KFAHYOAQSA-N
Inchi ID	InChI=1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13+,15+,16+,19+/m0/s1
PubChem CID	5312112
ChEMBL	CHEMBL420705
IUPHAR	415
BindingDB	50080398
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
297097	Adenosine receptor A1	P25099	Adora1	Rattus norvegicus (Rat)	326
297098	Adenosine receptor A1	P28190	ADORA1	Bos taurus (Bovine)	326
297099	Adenosine receptor A1	P30542	ADORA1	Homo sapiens (Human)	326
297100	Adenosine receptor A2a	P30543	Adora2a	Rattus norvegicus (Rat)	410
297104	Adenosine receptor A2a	P46616	ADORA2A	Cavia porcellus (Guinea pig)	409
297105	Adenosine receptor A2a	P29274	ADORA2A	Homo sapiens (Human)	412
554738	Adenosine receptor A2b	P29275	ADORA2B	Homo sapiens (Human)	332
297096	Adenosine receptor A3	P0DMS8	ADORA3	Homo sapiens (Human)	318
297103	Adenosine receptor A3	P28647	Adora3	Rattus norvegicus (Rat)	320
297102	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466

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