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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL195433
Molecular formula	C26H35FN4O2S
IUPAC name	1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea
Molecular weight	486.65
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	5.3
Synonyms	CCR3Antagonist 1-(5-Acetyl-4-methyl-thiazol-2-yl)-3-{(1R,2S)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-cyclohexyl}-urea BDBM50163636 ZINC13613346 CHEMBL-195433 275812-32-3 J3.634.338I CCR3 Antagonist 1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(5-acetyl-4-methylthiazol-2-yl)urea SCHEMBL18840897 [ Show all ]
Inchi Key	NDZYPHLNJZSQJY-QNWVGRARSA-N
Inchi ID	InChI=1S/C26H35FN4O2S/c1-17-24(18(2)32)34-26(28-17)30-25(33)29-23-8-4-3-7-21(23)16-31-13-5-6-20(15-31)14-19-9-11-22(27)12-10-19/h9-12,20-21,23H,3-8,13-16H2,1-2H3,(H2,28,29,30,33)/t20-,21-,23+/m0/s1
PubChem CID	11329244
ChEMBL	CHEMBL195433
IUPHAR	N/A
BindingDB	50163636
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
221021	C-C chemokine receptor type 1	P32246	CCR1	Homo sapiens (Human)	355
221025	C-C chemokine receptor type 2	P41597	CCR2	Homo sapiens (Human)	374
221019	C-C chemokine receptor type 3	P51677	CCR3	Homo sapiens (Human)	355
221020	C-C chemokine receptor type 3	O54814	Ccr3	Rattus norvegicus (Rat)	359
221024	C-C chemokine receptor type 5	P51681	CCR5	Homo sapiens (Human)	352
221026	C-X-C chemokine receptor type 1	P25024	CXCR1	Homo sapiens (Human)	350
221023	C-X-C chemokine receptor type 2	P25025	CXCR2	Homo sapiens (Human)	360
221022	Probable C-C chemokine receptor type 3	P51678	Ccr3	Mus musculus (Mouse)	359

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