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| Name | C-C chemokine receptor type 1 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | CCR1 |
| Synonym | macrophage inflammatory protein-1 alpha receptor MIP-1alpha-R MIP-1alpha/RANTES MIP-1alphaR MIP1aR [ Show all ] |
| Disease | Autoimmune diabetes Rheumatoid arthritis Chronic obstructive pulmonary disease |
| Length | 355 |
| Amino acid sequence | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF |
| UniProt | P32246 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P32246 |
| 3D structure model | This predicted structure model is from GPCR-EXP P32246. |
| BioLiP | N/A |
| Therapeutic Target Database | T16016 |
| ChEMBL | CHEMBL2413 |
| IUPHAR | 58 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 196 |  CHEMBL356764 | C22H24Cl2N2O | 403.347 | 3 / 1 | 4.8 | Yes |
| 305 |  CHEMBL2180512 | C25H31ClN2O2 | 426.985 | 2 / 1 | 5.7 | No |
| 426 |  CHEMBL2178571 | C36H48N4O3 | 584.805 | 5 / 2 | 5.5 | No |
| 553249 |  SCHEMBL18442513 | C36H48N4O3 | 584.805 | 5 / 2 | 5.5 | No |
| 1045 |  CHEMBL2322857 | C18H20ClF3N4O2 | 416.829 | 7 / 0 | 3.4 | Yes |
| 1338 |  CHEMBL3138115 | C59H70B2Cl2Na4O10 | 1123.68 | 10 / 2 | N/A | No |
| 2973 |  CHEMBL143029 | C29H31ClN2O2 | 475.029 | 4 / 1 | 5.6 | No |
| 4085 |  CHEMBL67757 | C27H34N4O4 | 478.593 | 6 / 3 | 3.5 | Yes |
| 4391 |  CHEMBL2322885 | C21H24Cl2F3N5O3 | 522.35 | 8 / 0 | 3.5 | No |
| 4907 |  CHEMBL2207082 | C15H11Cl3N4O2S | 417.689 | 5 / 1 | 3.4 | Yes |
| 5472 |  4'-Chloro-2,2':6',2''-terpyridine | C15H10ClN3 | 267.716 | 3 / 0 | 3.0 | Yes |
| 5642 |  CHEMBL2398758 | C23H34ClN3O2 | 419.994 | 3 / 1 | 4.8 | Yes |
| 5928 |  CHEMBL1171006 | C20H12ClF4NO5S | 489.822 | 10 / 2 | 5.1 | No |
| 6002 |  CHEMBL200680 | C27H27FN4O2 | 458.537 | 5 / 1 | 3.3 | Yes |
| 6066 |  CHEMBL3099950 | C22H25ClFN3O4 | 449.907 | 6 / 3 | 2.7 | Yes |
| 6109 |  CHEMBL143825 | C23H27ClN2O | 382.932 | 3 / 1 | 4.5 | Yes |
| 442010 |  CHEMBL399045 | C26H29Cl3N2O | 491.881 | 2 / 0 | 6.7 | No |
| 8608 |  CHEMBL2180506 | C23H26ClFN2O2 | 416.921 | 3 / 1 | 5.1 | No |
| 8998 |  SCHEMBL9927494 | C23H36ClN3O3 | 438.009 | 3 / 3 | 4.2 | Yes |
| 442058 |  CHEMBL3334817 | C23H36ClN3O3 | 438.009 | 3 / 3 | 4.2 | Yes |
| 9327 |  CHEMBL344751 | C26H28N2OS | 416.583 | 4 / 1 | 4.7 | Yes |
| 9358 |  CHEMBL2180550 | C24H29ClN2O3 | 428.957 | 3 / 2 | 4.2 | Yes |
| 10071 |  CHEMBL2112830 | C29H32N2O | 424.588 | 3 / 1 | 5.4 | No |
| 10121 |  CHEMBL247635 | C33H44F3N5O4 | 631.741 | 8 / 5 | 5.4 | No |
| 10396 |  CHEMBL2180495 | C23H27ClN2O2 | 398.931 | 2 / 1 | 4.5 | Yes |
| 12384 |  CHEMBL2322869 | C20H24Cl2F3N5O2 | 494.34 | 8 / 0 | 3.5 | Yes |
| 13454 |  CHEMBL250689 | C28H36FN3O2 | 465.613 | 4 / 2 | 5.2 | No |
| 15130 |  CHEMBL69900 | C24H35N3O3 | 413.562 | 4 / 3 | 3.9 | Yes |
| 15421 |  CHEMBL2322852 | C19H21Cl2F3N4O2 | 465.298 | 7 / 0 | 4.4 | Yes |
| 15422 |  CHEMBL2322853 | C19H21Cl2F3N4O2 | 465.298 | 7 / 0 | 4.4 | Yes |
| 16104 |  CHEMBL247455 | C30H41F3N6O4 | 606.691 | 8 / 6 | 3.9 | No |
| 18177 |  CHEMBL196908 | C23H23ClFN3O2 | 427.904 | 4 / 1 | 3.3 | Yes |
| 19019 |  CHEMBL2180497 | C25H31ClN2O2 | 426.985 | 2 / 1 | 5.3 | No |
| 19137 |  CHEMBL280751 | C30H41IN2O2 | 588.574 | 3 / 1 | N/A | No |
| 19410 |  CHEMBL401010 | C26H31F3N4O3 | 504.554 | 7 / 4 | 3.9 | No |
| 19871 |  CHEMBL303947 | C27H33N3O3 | 447.579 | 4 / 3 | 4.2 | Yes |
| 20132 |  CHEMBL2180518 | C24H29ClN2O3 | 428.957 | 3 / 1 | 5.2 | No |
| 20726 |  CHEMBL2207090 | C15H12ClFN4O2S | 366.795 | 6 / 1 | 2.5 | Yes |
| 522137 |  CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 522159 |  CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 22307 |  CHEMBL20532 | C21H21Cl2N3OS2 | 466.439 | 5 / 1 | 5.9 | No |
| 22535 |  CHEMBL420924 | C23H34N4O3 | 414.55 | 5 / 3 | 3.3 | Yes |
| 22991 |  CHEMBL124583 | C26H27F2N3O | 435.519 | 4 / 2 | 5.2 | No |
| 23301 |  CHEMBL2398764 | C30H33ClN4O3 | 533.069 | 3 / 3 | 5.2 | No |
| 24410 |  CHEMBL3137848 | C49H66Cl2N2O8 | 881.973 | 8 / 6 | 15.2 | No |
| 24650 |  CHEMBL2180519 | C23H29ClN2O3S | 449.006 | 4 / 1 | 4.6 | Yes |
| 24662 |  CHEMBL2180524 | C20H29ClN2O2 | 364.914 | 2 / 1 | 4.1 | Yes |
| 25706 |  CHEMBL123622 | C32H40ClN3O2 | 534.141 | 3 / 3 | 6.1 | No |
| 26350 |  CHEMBL2180537 | C20H29ClN2O2 | 364.914 | 2 / 1 | 4.3 | Yes |
| 26918 |  CHEMBL356099 | C28H33ClNO+ | 435.028 | 1 / 1 | 6.2 | No |
| 27186 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 27441 |  CHEMBL2398765 | C32H37ClN4O4 | 577.122 | 4 / 4 | 4.9 | No |
| 27918 |  CHEMBL390706 | C25H26Cl2N4O4 | 517.407 | 7 / 2 | 4.0 | No |
| 29511 |  CHEMBL2398723 | C24H35ClN2O4 | 451.004 | 4 / 3 | 3.8 | Yes |
| 29512 |  CHEMBL2398722 | C24H35ClN2O4 | 451.004 | 4 / 3 | 3.8 | Yes |
| 30102 |  CHEMBL3099960 | C24H30FN3O5 | 459.518 | 7 / 3 | 2.5 | Yes |
| 30599 |  AC1LA88L | C37H43N5O4 | 621.782 | 5 / 2 | 5.7 | No |
| 536791 |  CHEMBL3889627 | C23H27N5O3S | 453.561 | 5 / 2 | 2.6 | Yes |
| 31214 |  CHEMBL338624 | C36H37ClF3N3O2 | 636.156 | 6 / 3 | 7.8 | No |
| 31293 |  CHEMBL401009 | C25H31F3N4O3 | 492.543 | 7 / 4 | 3.4 | Yes |
| 32689 |  CHEMBL2398737 | C26H33ClN2O3 | 457.011 | 3 / 2 | 4.6 | Yes |
| 32970 |  SCHEMBL3053456 | C26H32ClN3O3 | 470.01 | 3 / 3 | 4.5 | Yes |
| 33399 |  CHEMBL34732 | C30H39IN2O2 | 586.558 | 3 / 1 | N/A | No |
| 33486 |  UNII-7W7511NPF8 | C20H20N2O3S | 368.451 | 6 / 1 | 1.8 | Yes |
| 34737 |  CHEMBL404259 | C21H22ClF3N4O2 | 454.878 | 7 / 3 | 3.7 | Yes |
| 35488 |  CHEMBL143374 | C27H30ClN2O+ | 434.0 | 2 / 1 | 5.4 | No |
| 36132 |  CHEMBL33104 | C31H41BrN2O2 | 553.585 | 3 / 1 | N/A | No |
| 36319 |  CHEMBL33761 | C29H41N2O+ | 433.66 | 1 / 1 | 6.9 | No |
| 36430 |  CHEMBL68581 | C26H32N4O3 | 448.567 | 5 / 3 | 3.6 | Yes |
| 36444 |  CHEMBL105659 | C34H40N4O2 | 536.72 | 4 / 0 | 6.7 | No |
| 36526 |  CHEMBL2434978 | C32H36N4O4S | 572.724 | 7 / 1 | 2.1 | No |
| 37963 |  CHEMBL289902 | C30H37Br2IN2O2 | 744.35 | 3 / 1 | N/A | No |
| 38223 |  CHEMBL142925 | C30H30ClN3O2 | 500.039 | 4 / 1 | 4.7 | No |
| 38307 |  CHEMBL473532 | C21H20ClF4N3O2 | 457.854 | 6 / 1 | 4.3 | Yes |
| 38401 |  CHEMBL2322851 | C18H20Cl2N4O4 | 427.282 | 6 / 1 | 2.9 | Yes |
| 39144 |  CHEMBL282285 | C21H22ClN3OS2 | 431.997 | 5 / 1 | 5.3 | No |
| 39231 |  CHEMBL389293 | C25H24ClFN4O3 | 482.94 | 7 / 2 | 3.2 | Yes |
| 39266 |  CHEMBL2207101 | C16H11Cl2F3N4O2S | 451.245 | 8 / 1 | 3.9 | Yes |
| 39433 |  CHEMBL234606 | C26H33FN4O3 | 468.573 | 7 / 4 | 2.6 | Yes |
| 39503 |  CHEMBL142004 | C27H31ClINO | 547.905 | 2 / 2 | N/A | No |
| 40342 |  CHEMBL2322844 | C20H26Cl2N4O2 | 425.354 | 4 / 0 | 4.2 | Yes |
| 40355 |  CHEMBL344989 | C23H24ClN3O | 393.915 | 4 / 1 | 3.9 | Yes |
| 41533 |  CHEMBL66457 | C26H32N4O4 | 464.566 | 6 / 4 | 2.1 | Yes |
| 41673 |  CHEMBL3679657 | C29H33N3O5 | 503.599 | 6 / 3 | 3.9 | No |
| 42921 |  CHEMBL246416 | C26H33F3N4O4 | 522.569 | 8 / 4 | 3.9 | No |
| 44153 |  CHEMBL342444 | C26H28ClN2O+ | 419.973 | 2 / 2 | 5.4 | No |
| 45281 |  CHEMBL346205 | C20H23ClN2OS | 374.927 | 4 / 1 | 3.9 | Yes |
| 45507 |  CHEMBL32305 | C28H34Br2N2O2 | 590.4 | 3 / 1 | 7.9 | No |
| 46304 |  CHEMBL2398754 | C27H33Cl2N3O3 | 518.479 | 3 / 2 | 5.3 | No |
| 47124 |  CHEMBL2322845 | C20H26Cl2N4O3 | 441.353 | 5 / 1 | 2.8 | Yes |
| 47971 |  CHEMBL2207086 | C15H13ClN4O2S | 348.805 | 5 / 1 | 2.4 | Yes |
| 48448 |  CHEMBL1210154 | C19H16N2O2S | 336.409 | 4 / 1 | 4.7 | Yes |
| 48469 |  SCHEMBL4318956 | C19H16N2O2S | 336.409 | 4 / 1 | 4.7 | Yes |
| 49660 |  CHEMBL391238 | C24H31ClFN5O3 | 491.992 | 6 / 3 | 2.4 | Yes |
| 50009 |  CHEMBL140270 | C32H32N2O | 460.621 | 3 / 1 | 6.3 | No |
| 50772 |  CHEMBL357434 | C27H34ClN3O | 452.039 | 4 / 1 | 4.9 | Yes |
| 51425 |  CHEMBL3099957 | C23H25ClN2O3S | 444.974 | 6 / 1 | 4.9 | Yes |
| 51538 |  CHEMBL442210 | C27H29N5O | 439.563 | 3 / 3 | 4.7 | Yes |
| 53050 |  1269775-42-9 | C24H34ClN7O3 | 504.032 | 7 / 3 | N/A | No |
| 53242 |  PharmaGSID_48521 | C31H49N5O4 | 555.764 | 7 / 0 | 4.1 | No |
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