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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL56375
Molecular formula	C20H26F4N4O5
IUPAC name	(5R,6S)-3-[3-[4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl]propyl]-5,6-dihydroxy-5-methyl-1,3-diazinane-2,4-dione
Molecular weight	478.445
Hydrogen bond acceptor	11
Hydrogen bond donor	3
XlogP	1.3
Synonyms	SCHEMBL7836397 BDBM50220743 Ro-1104253
Inchi Key	CFECXSNWRXZHNR-QFBILLFUSA-N
Inchi ID	InChI=1S/C20H26F4N4O5/c1-19(32)16(29)25-18(31)28(17(19)30)6-2-5-26-7-9-27(10-8-26)14-4-3-13(21)11-15(14)33-12-20(22,23)24/h3-4,11,16,29,32H,2,5-10,12H2,1H3,(H,25,31)/t16-,19+/m0/s1
PubChem CID	44298780
ChEMBL	CHEMBL56375
IUPHAR	N/A
BindingDB	50220743
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
40565	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
40564	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
40566	Alpha-1D adrenergic receptor	P23944	Adra1d	Rattus norvegicus (Rat)	561
40567	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572

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