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GPCR

Name	Alpha-1D adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1d
Synonym	ADRA1A Gpcr8 Adra-1 alpha1D-AR alpha1D-adrenoceptor alpha1a/d-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-1D adrenoreceptor Alpha-1D adrenoceptor ADRA1 Alpha-1A adrenergic receptor alpha 1D-adrenoreceptor alpha 1D-adrenoceptor adrenergic receptor delta1 Adrd1 ADRA1R RA42 [ Show all ]
Disease	N/A for non-human GPCRs
Length	561
Amino acid sequence	MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
UniProt	P23944
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL326
IUPHAR	24
DrugBank	N/A

Ligand

Name	CHEMBL56375
Molecular formula	C20H26F4N4O5
IUPAC name	(5R,6S)-3-[3-[4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl]propyl]-5,6-dihydroxy-5-methyl-1,3-diazinane-2,4-dione
Molecular weight	478.445
Hydrogen bond acceptor	11
Hydrogen bond donor	3
XlogP	1.3
Synonyms	SCHEMBL7836397 BDBM50220743 Ro-1104253
Inchi Key	CFECXSNWRXZHNR-QFBILLFUSA-N
Inchi ID	InChI=1S/C20H26F4N4O5/c1-19(32)16(29)25-18(31)28(17(19)30)6-2-5-26-7-9-27(10-8-26)14-4-3-13(21)11-15(14)33-12-20(22,23)24/h3-4,11,16,29,32H,2,5-10,12H2,1H3,(H,25,31)/t16-,19+/m0/s1
PubChem CID	44298780
ChEMBL	CHEMBL56375
IUPHAR	N/A
BindingDB	50220743
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
pA2/pKB	6.6 -	PMID12749888	ChEMBL

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