You can:
| Name | Melatonin receptor type 1A |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | MTNR1A |
| Synonym | MT1 receptor MelR Mel1a receptor Mel-1A-R |
| Disease | Insomnia Anxiety disorder Circadian rhythm sleep disorder Major depressive disorder Sleep disorders |
| Length | 350 |
| Amino acid sequence | MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV |
| UniProt | P48039 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P48039 |
| 3D structure model | This predicted structure model is from GPCR-EXP P48039. |
| BioLiP | N/A |
| Therapeutic Target Database | T97613 |
| ChEMBL | CHEMBL1945 |
| IUPHAR | 287 |
| DrugBank | BE0000515 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 912 |  CHEMBL2326200 | C22H25NO3 | 351.446 | 3 / 1 | 4.3 | Yes |
| 441708 |  CHEMBL3329375 | C20H19FN2O3 | 354.381 | 4 / 1 | 3.3 | Yes |
| 1099 |  CHEMBL476341 | C24H27NO3 | 377.484 | 3 / 2 | 4.3 | Yes |
| 1112 |  CHEMBL99502 | C14H17BrN2O2 | 325.206 | 2 / 2 | 2.8 | Yes |
| 521497 |  CHEMBL3760044 | C18H20N2O3 | 312.369 | 3 / 2 | 3.3 | Yes |
| 1813 |  CHEMBL138807 | C16H19NO3 | 273.332 | 3 / 2 | 1.8 | Yes |
| 2244 |  CHEMBL124914 | C14H18N2O2 | 246.31 | 3 / 1 | 2.5 | Yes |
| 4833 |  N-(2-(7-Methoxynaphth-1-yl)ethyl)propionamide | C16H19NO2 | 257.333 | 2 / 1 | 3.2 | Yes |
| 4835 |  SCHEMBL2299352 | C15H16N2O2 | 256.305 | 3 / 1 | 1.8 | Yes |
| 4858 |  CHEMBL14453 | C32H36N2O4 | 512.65 | 4 / 2 | 5.9 | No |
| 4929 |  CHEMBL139627 | C19H21NO3 | 311.381 | 3 / 1 | 2.9 | Yes |
| 5077 |  CHEMBL1774516 | C18H20F3NO2 | 339.358 | 5 / 1 | 3.6 | Yes |
| 5517 |  CHEMBL184562 | C26H31NO2 | 389.539 | 2 / 1 | 6.3 | No |
| 463654 |  CHEMBL3612611 | C14H16N2O2 | 244.294 | 3 / 1 | 1.8 | Yes |
| 7325 |  CHEMBL562328 | C18H25N3O2 | 315.417 | 3 / 1 | 1.5 | Yes |
| 8001 |  CHEMBL139091 | C11H13NO3 | 207.229 | 3 / 1 | 0.8 | Yes |
| 8075 |  CHEMBL1823015 | C18H19N3O2 | 309.369 | 3 / 2 | 2.6 | Yes |
| 9638 |  CHEMBL2112727 | C16H20N2O2 | 272.348 | 3 / 1 | 2.8 | Yes |
| 9884 |  AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
| 11504 |  CHEMBL141208 | C13H17NO4 | 251.282 | 4 / 1 | 1.3 | Yes |
| 12667 |  CHEMBL96562 | C20H19Cl2NO3 | 392.276 | 3 / 1 | 5.1 | No |
| 464446 |  CHEMBL3580912 | C15H16N2O2 | 256.305 | 3 / 1 | 3.1 | Yes |
| 521847 |  CHEMBL3740377 | C32H32F4N2O4 | 584.612 | 8 / 2 | 7.6 | No |
| 13609 |  CHEMBL300729 | C13H15N3O4 | 277.28 | 4 / 2 | 1.4 | Yes |
| 14671 |  CHEMBL361854 | C26H33NO2 | 391.555 | 2 / 1 | 6.0 | No |
| 14676 |  CHEMBL341705 | C16H22N2O2 | 274.364 | 3 / 1 | 2.4 | Yes |
| 14678 |  CHEMBL136531 | C16H22N2O2 | 274.364 | 3 / 1 | 2.4 | Yes |
| 15078 |  CHEMBL19432 | C14H19FN2O2 | 266.316 | 4 / 0 | 1.1 | Yes |
| 15535 |  920317-71-1 | C18H21NO2 | 283.371 | 2 / 1 | 3.2 | Yes |
| 16852 |  BRN 1379764 | C13H15NO2S | 249.328 | 3 / 1 | 2.5 | Yes |
| 17012 |  CHEMBL363321 | C18H19NO | 265.356 | 1 / 1 | 3.2 | Yes |
| 17788 |  CHEMBL123119 | C21H32N2O2 | 344.499 | 3 / 1 | 3.2 | Yes |
| 18432 |  17994-17-1 | C12H14N2O2 | 218.256 | 3 / 2 | 0.8 | Yes |
| 18930 |  CHEMBL457807 | C22H24BrN3O2 | 442.357 | 3 / 2 | 4.0 | Yes |
| 19435 |  CHEMBL138468 | C12H14N2O3 | 234.255 | 4 / 1 | 1.1 | Yes |
| 20133 |  CHEMBL113441 | C13H15IN2O2 | 358.179 | 2 / 2 | 1.5 | Yes |
| 553339 |  [125I]SD6 | C13H15IN2O2 | 356.18 | 2 / 2 | 1.5 | Yes |
| 20146 |  CHEMBL137998 | C16H19NO2 | 257.333 | 2 / 1 | 3.1 | Yes |
| 20288 |  CHEMBL298335 | C13H15N3O4 | 277.28 | 4 / 2 | 1.4 | Yes |
| 20757 |  CHEMBL34729 | C15H18N2O2 | 258.321 | 2 / 2 | 2.2 | Yes |
| 21354 |  CHEMBL139497 | C15H22N2O2 | 262.353 | 3 / 1 | 2.4 | Yes |
| 21363 |  CHEMBL181687 | C25H33NO2 | 379.544 | 2 / 1 | 6.2 | No |
| 21802 |  N-(3,3-diphenylpropyl)acetamide | C17H19NO | 253.345 | 1 / 1 | 3.3 | Yes |
| 21810 |  CHEMBL331636 | C17H24N2O2 | 288.391 | 3 / 1 | 3.9 | Yes |
| 22006 |  CHEMBL1813320 | C27H40N4O4 | 484.641 | 6 / 2 | 3.5 | Yes |
| 522131 |  CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 522163 |  CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 22915 |  CHEMBL1779803 | C12H12FNOS | 237.292 | 3 / 1 | 2.6 | Yes |
| 442579 |  CHEMBL3329371 | C22H33N3O2S | 403.585 | 4 / 1 | 3.3 | Yes |
| 23666 |  (hydroxymethylphenyl)agomelatine | C22H23NO3 | 349.43 | 3 / 2 | 3.5 | Yes |
| 24351 |  CHEMBL1095196 | C31H33NO5 | 499.607 | 5 / 1 | 6.1 | No |
| 465955 |  CHEMBL3612463 | C21H27N3O2 | 353.466 | 3 / 2 | 3.5 | Yes |
| 24826 |  CHEMBL1097496 | C30H34N2O5 | 502.611 | 5 / 2 | 5.1 | No |
| 24901 |  CHEMBL8004 | C18H20N2O2 | 296.37 | 3 / 2 | 3.5 | Yes |
| 459439 |  5-MeOT-N-pentanyl | C19H27N3O2 | 329.444 | 2 / 3 | 2.6 | Yes |
| 27189 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 27334 |  CHEMBL124783 | C16H22N2O2 | 274.364 | 3 / 1 | 3.4 | Yes |
| 27943 |  CHEMBL98956 | C13H15BrN2O2 | 311.179 | 2 / 2 | 2.3 | Yes |
| 27990 |  CHEMBL139133 | C12H15NO4 | 237.255 | 4 / 1 | 0.9 | Yes |
| 28020 |  CHEMBL1760954 | C14H20N4O2 | 276.34 | 4 / 2 | 0.2 | Yes |
| 29591 |  CHEMBL238049 | C20H24N2O2 | 324.424 | 3 / 1 | 3.9 | Yes |
| 30156 |  CHEMBL10328 | C21H22N2O | 318.42 | 1 / 1 | 3.7 | Yes |
| 466735 |  CHEMBL3580909 | C14H16N2O2 | 244.294 | 2 / 2 | 1.9 | Yes |
| 31278 |  CHEMBL1223277 | C12H17NO3 | 223.272 | 3 / 1 | 1.6 | Yes |
| 31279 |  N-[2-(3-Methoxyphenoxy)-1-methylethyl]acetamide | C12H17NO3 | 223.272 | 3 / 1 | 1.6 | Yes |
| 31282 |  CHEMBL1223278 | C12H17NO3 | 223.272 | 3 / 1 | 1.6 | Yes |
| 32376 |  CHEMBL139418 | C18H17NO4 | 311.337 | 4 / 1 | 2.4 | Yes |
| 32724 |  CHEMBL323332 | C13H15NO3 | 233.267 | 3 / 1 | 1.9 | Yes |
| 32839 |  CHEMBL1223280 | C12H17NO2S | 239.333 | 3 / 1 | 2.2 | Yes |
| 32840 |  N-{2-[(3-methoxyphenyl)thio]-1-methylethyl}acetamide | C12H17NO2S | 239.333 | 3 / 1 | 2.2 | Yes |
| 32843 |  CHEMBL1223281 | C12H17NO2S | 239.333 | 3 / 1 | 2.2 | Yes |
| 467016 |  CHEMBL3612602 | C22H26N2O | 334.463 | 2 / 1 | 4.3 | Yes |
| 34343 |  CHEMBL1095195 | C34H38N2O4 | 538.688 | 4 / 2 | 6.7 | No |
| 34378 |  CHEMBL99987 | C22H24N2O2 | 348.446 | 2 / 1 | 4.2 | Yes |
| 35510 |  CHEMBL1092646 | C20H25NO4 | 343.423 | 4 / 1 | 3.3 | Yes |
| 35532 |  CHEMBL3260984 | C19H29NO3 | 319.445 | 3 / 1 | 4.1 | Yes |
| 35872 |  CHEMBL382439 | C19H26N2O2 | 314.429 | 2 / 1 | 3.4 | Yes |
| 36456 |  920317-82-4 | C19H21NO3 | 311.381 | 3 / 1 | 3.5 | Yes |
| 37025 |  CHEMBL1774527 | C22H23NO3 | 349.43 | 3 / 1 | 3.0 | Yes |
| 37251 |  CHEMBL7567 | C18H20N2O2 | 296.37 | 3 / 1 | 3.2 | Yes |
| 37676 |  CHEMBL553105 | C18H26N2O2 | 302.418 | 3 / 2 | 3.7 | Yes |
| 38189 |  CHEMBL137949 | C15H21N3O2 | 275.352 | 2 / 3 | 1.5 | Yes |
| 38702 |  CHEMBL139744 | C16H22N2OS | 290.425 | 2 / 2 | 4.0 | Yes |
| 38894 |  SCHEMBL2299672 | C15H18N2O2 | 258.321 | 3 / 1 | 2.5 | Yes |
| 38896 |  SCHEMBL2296992 | C15H18N2O2 | 258.321 | 3 / 1 | 2.5 | Yes |
| 38898 |  SCHEMBL2296995 | C15H18N2O2 | 258.321 | 3 / 1 | 2.5 | Yes |
| 467717 |  CHEMBL3580917 | C13H13N3O2 | 243.266 | 4 / 1 | 2.1 | Yes |
| 39250 |  CHEMBL117617 | C23H21NO4 | 375.424 | 4 / 1 | 4.2 | Yes |
| 39256 |  CHEMBL136564 | C15H21N3O2 | 275.352 | 3 / 2 | 1.8 | Yes |
| 39259 |  CHEMBL136431 | C15H21N3O2 | 275.352 | 3 / 2 | 1.8 | Yes |
| 467792 |  CHEMBL3580924 | C14H16N4OS | 288.369 | 3 / 2 | 2.0 | Yes |
| 39722 |  N-(2,3-diphenylpropyl)acetamide | C17H19NO | 253.345 | 1 / 1 | 3.2 | Yes |
| 40097 |  CHEMBL233516 | C16H22N2O2 | 274.364 | 2 / 1 | 2.4 | Yes |
| 40701 |  CHEMBL138321 | C15H17NO3 | 259.305 | 3 / 1 | 2.3 | Yes |
| 41204 |  CHEMBL99534 | C12H14N2O2 | 218.256 | 2 / 2 | 1.2 | Yes |
| 467972 |  CHEMBL3612469 | C19H22N2O | 294.398 | 2 / 1 | 3.3 | Yes |
| 467973 |  CHEMBL3612470 | C19H22N2O | 294.398 | 2 / 1 | 3.3 | Yes |
| 467974 |  CHEMBL3612468 | C19H22N2O | 294.398 | 2 / 1 | 3.3 | Yes |
| 468004 |  CHEMBL3628489 | C14H15NO4 | 261.277 | 4 / 1 | 1.0 | Yes |
| 42160 |  CHEMBL514280 | C24H29NO2 | 363.501 | 2 / 1 | 4.9 | Yes |
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