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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melatonin receptor type 1A
Species	Homo sapiens (Human)
Gene	MTNR1A
Synonym	MT1 receptor MelR Mel1a receptor Mel-1A-R
Disease	Insomnia Anxiety disorder Circadian rhythm sleep disorder Major depressive disorder Sleep disorders
Length	350
Amino acid sequence	MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
UniProt	P48039
Protein Data Bank	N/A
GPCR-HGmod model	P48039
3D structure model	This predicted structure model is from GPCR-EXP P48039.
BioLiP	N/A
Therapeutic Target Database	T97613
ChEMBL	CHEMBL1945
IUPHAR	287
DrugBank	BE0000515

Ligand

Name	CHEMBL3628489
Molecular formula	C14H15NO4
IUPAC name	N-[2-(6-methoxy-2-oxochromen-4-yl)ethyl]acetamide
Molecular weight	261.277
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	1.0
Synonyms	BDBM50127639
Inchi Key	CGOUMZHIQFGLAI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H15NO4/c1-9(16)15-6-5-10-7-14(17)19-13-4-3-11(18-2)8-12(10)13/h3-4,7-8H,5-6H2,1-2H3,(H,15,16)
PubChem CID	122193492
ChEMBL	CHEMBL3628489
IUPHAR	N/A
BindingDB	50127639
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	69.0 %	PMID26367450	ChEMBL
Ki	13.0 nM	PMID26367450	BindingDB,ChEMBL

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