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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melatonin receptor type 1A
Species	Homo sapiens (Human)
Gene	MTNR1A
Synonym	MT1 receptor MelR Mel1a receptor Mel-1A-R
Disease	Insomnia Anxiety disorder Circadian rhythm sleep disorder Major depressive disorder Sleep disorders
Length	350
Amino acid sequence	MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
UniProt	P48039
Protein Data Bank	N/A
GPCR-HGmod model	P48039
3D structure model	This predicted structure model is from GPCR-EXP P48039.
BioLiP	N/A
Therapeutic Target Database	T97613
ChEMBL	CHEMBL1945
IUPHAR	287
DrugBank	BE0000515

Ligand

Name	CHEMBL3740377
Molecular formula	C32H32F4N2O4
IUPAC name	N-[2-[7-[4-[8-[2-[(2,2-difluoroacetyl)amino]ethyl]naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]-2,2-difluoroacetamide
Molecular weight	584.612
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	7.6
Synonyms	N/A
Inchi Key	ASNVLUVKCDAISR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C32H32F4N2O4/c33-29(34)31(39)37-15-13-23-7-3-5-21-9-11-25(19-27(21)23)41-17-1-2-18-42-26-12-10-22-6-4-8-24(28(22)20-26)14-16-38-32(40)30(35)36/h3-12,19-20,29-30H,1-2,13-18H2,(H,37,39)(H,38,40)
PubChem CID	127041170
ChEMBL	CHEMBL3740377
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	11.75 nM	MedChemComm, (2015) 6:7:1340	ChEMBL
Ki	12.0 nM	MedChemComm, (2015) 6:7:1340	ChEMBL

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