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| Name | Neurotensin receptor type 1 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | NTSR1 |
| Synonym | NTSR1 NTS1 receptor NTRH NTR1 NTR [ Show all ] |
| Disease | Acute or chronic pain Alcohol use disorders Pain Inflammatory bowel disease Neurological disease |
| Length | 418 |
| Amino acid sequence | MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY |
| UniProt | P30989 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P30989 |
| 3D structure model | This predicted structure model is from GPCR-EXP P30989. |
| BioLiP | N/A |
| Therapeutic Target Database | T02728 |
| ChEMBL | CHEMBL4123 |
| IUPHAR | 309 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 3347 |  CHEMBL341884 | C39H64N12O8 | 829.017 | 12 / 8 | 1.1 | No |
| 441848 |  CHEMBL3315221 | C25H25N3O3 | 415.493 | 4 / 2 | 4.7 | Yes |
| 3812 |  CHEMBL2431236 | C28H30N4O3 | 470.573 | 7 / 0 | 5.5 | No |
| 441884 |  CHEMBL3315219 | C26H26N2O3 | 414.505 | 3 / 2 | 5.6 | No |
| 441885 |  CHEMBL3315199 | C26H26N2O3 | 414.505 | 3 / 2 | 5.6 | No |
| 4761 |  CHEMBL503059 | C39H66N12O8 | 831.033 | 11 / 10 | -2.3 | No |
| 7618 |  MLS000709291 | C17H25N5O3 | 347.419 | 5 / 2 | 3.0 | Yes |
| 9889 |  AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
| 11385 |  MLS002166510 | C24H26O7 | 426.465 | 7 / 0 | 4.9 | Yes |
| 12589 |  4-octyl-1,2,3,4-tetrahydro-9H-cyclopenta[b]quinolin-9-imine | C20H28N2 | 296.458 | 2 / 1 | 5.9 | No |
| 14297 |  CHEMBL508567 | C41H67N11O7 | 826.057 | 10 / 10 | -0.5 | No |
| 15863 |  CHEMBL518675 | C26H22ClF3N4O4 | 546.931 | 9 / 2 | 6.6 | No |
| 442320 |  CHEMBL3315216 | C27H28N2O3 | 428.532 | 3 / 1 | 6.0 | No |
| 442321 |  CHEMBL3315220 | C27H28N2O3 | 428.532 | 3 / 1 | 6.0 | No |
| 17218 |  1-(cyclohexylamino)-3-(6-methyl-1,2,3,4-tetrahydro-9H-carbazol-9-yl)propan-2-ol | C22H32N2O | 340.511 | 2 / 2 | 4.3 | Yes |
| 20266 |  BDBM58043 | C18H18N4O3S2 | 402.487 | 8 / 1 | 3.5 | Yes |
| 522151 |  CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 522182 |  CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
| 25204 |  MLS000663547 | C17H16N6O5 | 384.352 | 8 / 2 | 1.3 | Yes |
| 25850 |  CHEMBL1766936 | C39H66N12O8 | 831.033 | 11 / 11 | -2.5 | No |
| 26365 |  AC1NUOM1 | C20H15ClN4O | 362.817 | 3 / 1 | 3.9 | Yes |
| 26796 |  CHEMBL405160 | C70H116N22O20 | 1585.83 | 27 / 20 | -12.2 | No |
| 27208 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 27668 |  MLS000559431 | C32H33N3O3 | 507.634 | 5 / 1 | 5.0 | No |
| 27934 |  methyl 2-[4-[[[2-[N-(benzenesulfonyl)-2-methoxyanilino]acetyl]hydrazinylidene]methyl]phenoxy]acetate | C25H25N3O7S | 511.549 | 9 / 1 | 3.5 | No |
| 27936 |  MLS001197324 | C25H25N3O7S | 511.549 | 9 / 1 | 3.5 | No |
| 29469 |  CHEMBL1626334 | C21H22NO3+ | 336.411 | 3 / 1 | 3.8 | Yes |
| 30246 |  3-phenyl-1,4-benzodioxine-2-carbaldehyde | C15H10O3 | 238.242 | 3 / 0 | 2.9 | Yes |
| 30278 |  MolPort-000-745-232 | C20H29BrN2 | 377.37 | 2 / 1 | N/A | N/A |
| 31102 |  CHEMBL3099776 | C25H23ClN4O3 | 462.934 | 5 / 2 | 5.2 | No |
| 32319 |  CHEMBL3086356 | C50H67FN8O10 | 959.13 | 15 / 5 | 2.9 | No |
| 33481 |  UNII-7W7511NPF8 | C20H20N2O3S | 368.451 | 6 / 1 | 1.8 | Yes |
| 33981 |  CHEMBL505695 | C38H63N11O8 | 801.991 | 10 / 10 | 0.6 | No |
| 34035 |  CHEMBL3099779 | C25H24N4O3 | 428.492 | 5 / 2 | 4.5 | Yes |
| 548294 |  CHEMBL3951982 | C40H65BrN10O8 | 893.926 | 11 / 9 | -1.1 | No |
| 36158 |  MLS000879430 | C32H35NO5 | 513.634 | 6 / 0 | 6.0 | No |
| 37099 |  MLS000334786 | C24H17N5O2 | 407.433 | 5 / 1 | 3.8 | Yes |
| 37100 |  N-[[3-(1-benzofuran-2-yl)-1-phenylpyrazol-4-yl]methylideneamino]pyridine-3-carboxamide | C24H17N5O2 | 407.433 | 5 / 1 | 3.8 | Yes |
| 37276 |  CHEMBL505906 | C39H66N10O8 | 803.019 | 11 / 10 | -1.5 | No |
| 37512 |  MLS001003365 | C20H22N2O7S | 434.463 | 7 / 1 | 2.9 | Yes |
| 38091 |  F-L-Leu | C21H23NO4 | 353.418 | 4 / 2 | 4.4 | Yes |
| 38863 |  CHEMBL2431113 | C22H26N4O3 | 394.475 | 7 / 0 | 3.9 | Yes |
| 39002 |  MLS000572885 | C24H21ClN2O2 | 404.894 | 3 / 0 | 5.2 | No |
| 443254 |  CHEMBL3315195 | C16H19BrN2O3 | 367.243 | 3 / 2 | 3.5 | Yes |
| 40576 |  CHEMBL434227 | C39H66N12O8 | 831.033 | 12 / 11 | -1.5 | No |
| 548362 |  CHEMBL3950695 | C38H63BrN8O7 | 823.875 | 10 / 8 | -1.0 | No |
| 548364 |  CHEMBL3979668 | C38H63BrN8O7 | 823.875 | 10 / 8 | -1.0 | No |
| 43025 |  CHEMBL2431125 | C24H28N4O2 | 404.514 | 6 / 0 | 4.6 | Yes |
| 43400 |  MLS000109200 | C21H24N2O6S | 432.491 | 7 / 1 | 2.1 | Yes |
| 43560 |  MLS000587237 | C20H18N2O4 | 350.374 | 4 / 1 | 3.6 | Yes |
| 43562 |  AC1LQXGA | C20H18N2O4 | 350.374 | 4 / 1 | 3.6 | Yes |
| 44222 |  Cipargamin | C19H14Cl2FN3O | 390.239 | 3 / 3 | 3.9 | Yes |
| 45212 |  CHEMBL507382 | C43H68N12O8 | 881.093 | 11 / 11 | -2.0 | No |
| 548419 |  CHEMBL3899699 | C36H57BrN8O8 | 809.804 | 11 / 8 | -1.9 | No |
| 46313 |  MLS000830378 | C28H26F3N3O2 | 493.53 | 6 / 1 | 5.3 | No |
| 47075 |  MLS001047411 | C19H14N2O3 | 318.332 | 3 / 1 | 3.3 | Yes |
| 47078 |  AC1LIT1K | C19H14N2O3 | 318.332 | 3 / 1 | 3.3 | Yes |
| 47305 |  CHEMBL266571 | C41H67N11O7 | 826.057 | 10 / 10 | -0.5 | No |
| 47327 |  MLS000335649 | C28H38N2O6 | 498.62 | 6 / 2 | 4.2 | Yes |
| 48424 |  CHEMBL1210154 | C19H16N2O2S | 336.409 | 4 / 1 | 4.7 | Yes |
| 48461 |  SCHEMBL4318956 | C19H16N2O2S | 336.409 | 4 / 1 | 4.7 | Yes |
| 49277 |  MLS000521446 | C21H22NO3+ | 336.411 | 3 / 1 | 3.8 | Yes |
| 51264 |  SR 142948A | C39H52ClN5O6 | 722.324 | 8 / 3 | N/A | No |
| 52412 |  3-{[2-(4-nitrophenyl)quinazolin-4-yl]amino}phenol | C20H14N4O3 | 358.357 | 6 / 2 | 4.9 | Yes |
| 52486 |  MLS000702659 | C13H16N2O3 | 248.282 | 4 / 0 | 2.3 | Yes |
| 53190 |  CHEMBL344067 | C40H66N12O8 | 843.044 | 12 / 9 | 1.4 | No |
| 54707 |  MLS000520139 | C22H26BrNO5 | 464.356 | 5 / 1 | 4.7 | Yes |
| 54769 |  MLS000417396 | C27H21FN4O3S | 500.548 | 6 / 3 | 5.5 | No |
| 55279 |  CHEMBL414029 | C41H69N13O9 | 888.085 | 12 / 12 | -2.7 | No |
| 55560 |  CHEMBL226876 | C25H29ClN4O2S | 485.043 | 4 / 2 | 4.3 | Yes |
| 55785 |  GNF-Pf-2017 | C21H34N2 | 314.517 | 2 / 1 | 6.2 | No |
| 443945 |  CHEMBL3315222 | C26H26N2O3 | 414.505 | 3 / 2 | 5.6 | No |
| 57459 |  CHEMBL344020 | C35H57N9O7 | 715.897 | 11 / 7 | 1.9 | No |
| 58230 |  SMR000221222 | C34H29N3O3 | 527.624 | 4 / 2 | 4.9 | No |
| 58808 |  CHEMBL141910 | C37H60N10O7 | 756.95 | 12 / 7 | 1.5 | No |
| 58990 |  MLS000390145 | C22H15ClN2O | 358.825 | 2 / 1 | 5.6 | No |
| 59462 |  CHEMBL343970 | C33H53N9O7 | 687.843 | 11 / 7 | 1.2 | No |
| 59559 |  CHEMBL3099780 | C23H26N4O5 | 438.484 | 7 / 2 | 3.1 | Yes |
| 60406 |  MLS001033995 | C24H22Cl2N2O | 425.353 | 2 / 3 | 5.4 | No |
| 61576 |  SCHEMBL604437 | C18H25N5O | 327.432 | 6 / 2 | 1.3 | Yes |
| 61620 |  CHEMBL2431237 | C28H30N4O3 | 470.573 | 7 / 0 | 5.5 | No |
| 548625 |  CHEMBL3890335 | C34H54BrN7O7 | 752.752 | 10 / 7 | -1.2 | No |
| 62113 |  CHEMBL1766945 | C39H66N10O8 | 803.019 | 11 / 9 | -1.4 | No |
| 63561 |  CHEMBL1791383 | C48H87N15O9 | 1018.32 | 16 / 15 | -4.4 | No |
| 64702 |  CHEMBL2431110 | C17H22N4O2 | 314.389 | 6 / 1 | 1.9 | Yes |
| 65102 |  CHEMBL408534 | C74H102N16O15S | 1487.79 | 19 / 16 | 0.0 | No |
| 66199 |  CHEMBL1766929 | C38H64N12O8 | 817.006 | 11 / 11 | -4.0 | No |
| 66201 |  CHEMBL1766932 | C38H64N12O8 | 817.006 | 11 / 11 | -4.0 | No |
| 66203 |  CHEMBL342252 | C38H64N12O8 | 817.006 | 11 / 11 | -4.0 | No |
| 66209 |  CHEMBL1766934 | C38H64N12O8 | 817.006 | 11 / 11 | -4.0 | No |
| 444290 |  neurotensin (8-13) | C38H64N12O8 | 817.006 | 11 / 11 | -4.0 | No |
| 66210 |  CHEMBL1766931 | C38H64N12O8 | 817.006 | 11 / 11 | -4.0 | No |
| 66213 |  CHEMBL1766933 | C38H64N12O8 | 817.006 | 11 / 11 | -4.0 | No |
| 66214 |  CHEMBL1766930 | C38H64N12O8 | 817.006 | 11 / 11 | -4.0 | No |
| 66291 |  MLS000570494 | C21H17BrFN3O2S | 474.348 | 6 / 1 | 4.4 | Yes |
| 444346 |  GPR39-C3 | C18H19ClN6O2S | 418.9 | 8 / 3 | 2.6 | Yes |
| 444354 |  CHEMBL3315223 | C25H25N3O3 | 415.493 | 4 / 2 | 4.6 | Yes |
| 68133 |  CHEMBL1172376 | C41H70ClN9O8 | 852.516 | 10 / 8 | N/A | No |
| 69589 |  CHEMBL508130 | C39H66N12O8 | 831.033 | 11 / 10 | -2.3 | No |
| 71470 |  CHEMBL2431135 | C26H25FN4O2 | 444.51 | 7 / 0 | 5.3 | No |
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