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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neurotensin receptor type 1
Species	Homo sapiens (Human)
Gene	NTSR1
Synonym	NTSR1 NTS1 receptor NTRH NTR1 NTR NT-R-1 NT-1R neurotensin receptor type 1 neurotensin receptor 1 (high affinity) Levocabastin-insensitive neurotensin receptor High-affinity levocabastine-insensitive neurotensin receptor [ Show all ]
Disease	Acute or chronic pain Alcohol use disorders Pain Inflammatory bowel disease Neurological disease
Length	418
Amino acid sequence	MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
UniProt	P30989
Protein Data Bank	N/A
GPCR-HGmod model	P30989
3D structure model	This predicted structure model is from GPCR-EXP P30989.
BioLiP	N/A
Therapeutic Target Database	T02728
ChEMBL	CHEMBL4123
IUPHAR	309
DrugBank	N/A

Ligand

Name	GNF-Pf-2017
Molecular formula	C21H34N2
IUPAC name	4-nonyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-imine
Molecular weight	314.517
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	6.2
Synonyms	AC1LZD98 MLS000711279 BDBM79567 STK042510 4-nonyl-1,2,3,4,5,6,7,8-octahydro-9H-cyclopenta[b]quinolin-9-imine 4-nonyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-imine;hydrobromide AKOS005383809 MolPort-002-561-337 CHEMBL586602 VU0287633-3 4-Nonyl-1,2,3,4,5,6,7,8-octahydro-cyclopenta[b]quinolin-9-ylideneamine MCULE-6396696181 BAS 00138336 SMR000281046 (4-nonyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-ylidene)amine;hydrobromide 4-nonyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-imine cid_16192607 ZINC17413891 [ Show all ]
Inchi Key	DBKXHMVYXBVNRD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H34N2/c1-2-3-4-5-6-7-10-16-23-19-14-9-8-12-17(19)21(22)18-13-11-15-20(18)23/h22H,2-16H2,1H3
PubChem CID	1919229
ChEMBL	N/A
IUPHAR	N/A
BindingDB	79567
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6650.0 nM	N/A	BindingDB

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