You can:
| Name | 5-hydroxytryptamine receptor 1F |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | HTR1F |
| Synonym | 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled serotonin receptor 1F 5-HT-1F 5-HT1Ebeta HTR1EL [ Show all ] |
| Disease | Migraine |
| Length | 366 |
| Amino acid sequence | MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC |
| UniProt | P30939 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P30939 |
| 3D structure model | This predicted structure model is from GPCR-EXP P30939. |
| BioLiP | N/A |
| Therapeutic Target Database | T78656 |
| ChEMBL | CHEMBL1805 |
| IUPHAR | 5 |
| DrugBank | BE0000460, BE0004958 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 5051 |  CHEMBL105478 | C22H25FN4O | 380.467 | 4 / 2 | 3.8 | Yes |
| 5250 |  SB-258719 | C18H30N2O2S | 338.51 | 4 / 0 | 3.5 | Yes |
| 6278 |  CHEMBL76237 | C19H22N2O3S | 358.456 | 4 / 0 | 3.5 | Yes |
| 536145 |  CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
| 8208 |  BW-723C86 | C16H18N2OS | 286.393 | 3 / 2 | 3.0 | Yes |
| 9001 |  naratriptan | C17H25N3O2S | 335.466 | 4 / 2 | 2.0 | Yes |
| 11063 |  tryptamine | C10H12N2 | 160.22 | 1 / 2 | 1.6 | Yes |
| 13652 |  8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
| 14248 |  180083-23-2 | C32H32N4O3 | 520.633 | 6 / 0 | 5.6 | No |
| 16774 |  Pipamperone | C21H30FN3O2 | 375.488 | 5 / 1 | 2.0 | Yes |
| 17017 |  NAN-190 hydrobromide | C23H28BrN3O3 | 474.399 | 5 / 1 | N/A | N/A |
| 19947 |  CHEMBL187581 | C20H21F3N4O | 390.41 | 7 / 2 | 3.6 | Yes |
| 21143 |  SCHEMBL3825498 | C23H32N2O2S | 400.581 | 4 / 0 | 4.9 | Yes |
| 21156 |  CHEMBL114012 | C23H32N2O2S | 400.581 | 4 / 0 | 4.9 | Yes |
| 23174 |  1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | C11H16INO2 | 321.158 | 3 / 1 | 2.5 | Yes |
| 26541 |  CHEMBL321133 | C21H24N4O2 | 364.449 | 4 / 2 | 2.8 | Yes |
| 26609 |  Yohimbine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 26649 |  CHEBI:48565 | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 27047 |  SB-357134 | C17H18Br2FN3O3S | 523.215 | 7 / 2 | 3.4 | No |
| 27088 |  CHEMBL445651 | C20H20FN3O2 | 353.397 | 5 / 1 | 3.3 | Yes |
| 33202 |  CHEMBL102250 | C18H20N4O2 | 324.384 | 4 / 2 | 1.9 | Yes |
| 39480 |  CHEMBL104484 | C21H21N5O | 359.433 | 4 / 2 | 2.5 | Yes |
| 41461 |  CHEMBL420475 | C18H24N4O | 312.417 | 3 / 2 | 2.2 | Yes |
| 42820 |  CHEMBL103058 | C16H20N4O | 284.363 | 3 / 2 | 1.2 | Yes |
| 43490 |  CHEMBL576315 | C15H15N3O2S | 301.364 | 4 / 1 | 1.1 | Yes |
| 43894 |  CHEMBL318110 | C13H17N3O | 231.299 | 2 / 2 | 0.7 | Yes |
| 469564 |  CHEMBL3617555 | C21H23FN2O2 | 354.425 | 4 / 1 | 3.4 | Yes |
| 54224 |  CHEMBL609742 | C19H20ClN3O2S | 389.898 | 4 / 3 | 3.6 | Yes |
| 54238 |  BDBM50159175 | C19H20ClN3O2S | 389.898 | 4 / 3 | 3.6 | Yes |
| 470322 |  CHEMBL3617549 | C20H21FN2O2 | 340.398 | 4 / 1 | 3.0 | Yes |
| 60140 |  CHEMBL317535 | C15H20N2O2 | 260.337 | 3 / 1 | 2.9 | Yes |
| 62116 |  CHEMBL361303 | C21H22FN3O | 351.425 | 3 / 1 | 3.4 | Yes |
| 62228 |  spiperone | C23H26FN3O2 | 395.478 | 5 / 1 | 3.0 | Yes |
| 64693 |  CHEMBL105743 | C20H22N4O | 334.423 | 3 / 2 | 2.8 | Yes |
| 66043 |  Dipropyl-5-CT | C17H25N3O | 287.407 | 2 / 2 | 2.2 | Yes |
| 69704 |  CHEMBL282971 | C23H26ClN3O3S2 | 492.049 | 7 / 1 | 5.2 | No |
| 69714 |  CHEMBL29433 | C23H26ClN3O3S2 | 492.049 | 7 / 1 | 5.2 | No |
| 71444 |  CHEMBL2113386 | C20H22IN3O2S | 495.379 | 4 / 3 | 3.5 | Yes |
| 71681 |  CHEMBL103424 | C16H21N3O | 271.364 | 2 / 2 | 1.8 | Yes |
| 76572 |  Zacopride | C15H20ClN3O2 | 309.794 | 4 / 2 | 1.7 | Yes |
| 80594 |  CHEMBL319920 | C19H20FN3O3S | 389.445 | 6 / 1 | 3.2 | Yes |
| 83887 |  Ketanserin | C22H22FN3O3 | 395.434 | 5 / 1 | 2.6 | Yes |
| 90014 |  CHEMBL321343 | C20H21N5O3 | 379.42 | 5 / 2 | 2.6 | Yes |
| 97161 |  CHEMBL92139 | C18H20N2O2S | 328.43 | 3 / 0 | 3.5 | Yes |
| 99070 |  LY 344864 racemate | C21H22FN3O | 351.425 | 3 / 2 | 3.8 | Yes |
| 102947 |  CHEMBL369391 | C19H20FN3O2 | 341.386 | 5 / 1 | 3.3 | Yes |
| 102990 |  CHEMBL191460 | C38H47F6N3O5 | 739.8 | 13 / 3 | N/A | No |
| 107450 |  CHEMBL173949 | C20H18F3N3O2 | 389.378 | 7 / 1 | 3.4 | Yes |
| 109126 |  SERTINDOLE | C24H26ClFN4O | 440.947 | 3 / 1 | 4.1 | Yes |
| 116711 |  CHEMBL606556 | C20H22ClN3O2S | 403.925 | 4 / 2 | 4.1 | Yes |
| 116722 |  BDBM50159187 | C20H22ClN3O2S | 403.925 | 4 / 2 | 4.1 | Yes |
| 119442 |  CHEMBL313714 | C26H31FN6O | 462.573 | 6 / 3 | 2.9 | Yes |
| 477702 |  CHEMBL3617560 | C19H20FN3O2 | 341.386 | 5 / 1 | 2.3 | Yes |
| 120307 |  CHEMBL186951 | C20H22ClFN4O | 388.871 | 5 / 2 | 4.1 | Yes |
| 121837 |  CHEMBL105118 | C20H21N5O3 | 379.42 | 5 / 2 | 2.6 | Yes |
| 122477 |  CHEMBL177258 | C20H20FN3O2 | 353.397 | 5 / 1 | 3.2 | Yes |
| 124321 |  CHEMBL104384 | C20H21FN4O | 352.413 | 4 / 2 | 2.9 | Yes |
| 125659 |  SB-269970 | C18H28N2O3S | 352.493 | 5 / 1 | 2.9 | Yes |
| 133901 |  CHEMBL178066 | C20H22FN3O | 339.414 | 3 / 2 | 3.7 | Yes |
| 136329 |  CHEMBL157910 | C17H18Cl3N3O3S | 450.759 | 6 / 2 | 3.8 | Yes |
| 136871 |  CHEMBL184597 | C20H21FN4O | 352.413 | 4 / 2 | 3.1 | Yes |
| 143459 |  CHEMBL177238 | C20H19ClFN3O2 | 387.839 | 5 / 1 | 3.8 | Yes |
| 146437 |  CHEMBL104692 | C20H21N5O3 | 379.42 | 5 / 2 | 2.6 | Yes |
| 146736 |  CHEMBL116448 | C18H27BrN2O2S | 415.39 | 4 / 0 | 4.0 | Yes |
| 149293 |  CHEMBL606547 | C20H22ClN3O2S | 403.925 | 4 / 2 | 4.1 | Yes |
| 149300 |  BDBM50159180 | C20H22ClN3O2S | 403.925 | 4 / 2 | 4.1 | Yes |
| 152244 |  CHEMBL105955 | C17H24N4O | 300.406 | 3 / 2 | 2.0 | Yes |
| 154019 |  BDBM86527 | C18H26N4O2S | 362.492 | 5 / 1 | 1.4 | Yes |
| 154040 |  Mesulergine | C18H26N4O2S | 362.492 | 5 / 1 | 1.4 | Yes |
| 155998 |  XANOMELINE | C14H23N3OS | 281.418 | 5 / 0 | 3.3 | Yes |
| 158197 |  170230-39-4 | C28H30N4O4 | 486.572 | 7 / 1 | 5.0 | Yes |
| 159354 |  5-METHOXYTRYPTAMINE | C11H14N2O | 190.246 | 2 / 2 | 0.5 | Yes |
| 163645 |  CHEMBL449406 | C21H24N4O | 348.45 | 3 / 2 | 3.2 | Yes |
| 163830 |  CHEMBL414628 | C19H22IN3O3S | 499.367 | 6 / 1 | 2.8 | Yes |
| 163962 |  pindolol | C14H20N2O2 | 248.326 | 3 / 3 | 1.8 | Yes |
| 164405 |  CHEMBL321562 | C21H24N4O2 | 364.449 | 4 / 2 | 2.8 | Yes |
| 166667 |  CHEMBL102292 | C16H23N5O | 301.394 | 3 / 3 | 1.4 | Yes |
| 171177 |  15532-75-9 | C11H13F3N2 | 230.234 | 5 / 1 | 2.3 | Yes |
| 171257 |  CHEMBL316979 | C21H21FN4O | 364.424 | 4 / 2 | 2.9 | Yes |
| 484445 |  CHEMBL3617554 | C20H20ClFN2O2 | 374.84 | 4 / 1 | 3.7 | Yes |
| 174364 |  CHEMBL273921 | C24H27FN4O2 | 422.504 | 4 / 1 | 3.0 | Yes |
| 174817 |  Methysergidum | C21H27N3O2 | 353.466 | 3 / 2 | 2.3 | Yes |
| 174833 |  1-Methyllysergic acid butanolamide | C21H27N3O2 | 353.466 | 3 / 2 | 2.3 | Yes |
| 174872 |  methysergide | C21H27N3O2 | 353.466 | 3 / 2 | 2.3 | Yes |
| 175632 |  sumatriptan | C14H21N3O2S | 295.401 | 4 / 2 | 0.9 | Yes |
| 177151 |  CHEMBL102182 | C27H27FN4O | 442.538 | 4 / 2 | 4.9 | Yes |
| 179155 |  CHEMBL187308 | C20H19ClFN3O2 | 387.839 | 5 / 1 | 3.9 | Yes |
| 182685 |  CHEMBL318105 | C13H18N4 | 230.315 | 3 / 2 | 1.3 | Yes |
| 191612 |  haloperidol | C21H23ClFNO2 | 375.868 | 4 / 1 | 3.2 | Yes |
| 192221 |  SB-271046 | C20H22ClN3O3S2 | 451.984 | 7 / 2 | 4.2 | Yes |
| 554285 |  dihydroergotamine | C33H37N5O5 | 583.689 | 6 / 3 | 2.4 | No |
| 487320 |  CHEMBL3617557 | C19H20FN3O2 | 341.386 | 5 / 1 | 2.6 | Yes |
| 197462 |  CHEMBL104720 | C17H22N4O | 298.39 | 3 / 2 | 1.6 | Yes |
| 198002 |  CHEMBL421287 | C19H20FN3O | 325.387 | 3 / 2 | 3.3 | Yes |
| 199129 |  CHEMBL322018 | C14H18N4O | 258.325 | 3 / 3 | 0.7 | Yes |
| 199352 |  CHEMBL187928 | C39H36F3N3O3 | 651.73 | 8 / 2 | N/A | No |
| 199575 |  alpha-methyl-5-HT | C11H14N2O | 190.246 | 2 / 3 | 0.6 | Yes |
| 202037 |  BDBM85612 | C24H33NO2S | 399.593 | 3 / 0 | 5.8 | No |
| 202040 |  BDBM85613 | C24H33NO2S | 399.593 | 3 / 0 | 5.8 | No |
| 202806 |  LY334370 | C21H22FN3O | 351.425 | 3 / 2 | 3.6 | Yes |
zhanglab
zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417