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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 1F
Species	Homo sapiens (Human)
Gene	HTR1F
Synonym	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled serotonin receptor 1F 5-HT-1F 5-HT1Ebeta HTR1EL 5-HT1F 5-HT1F receptor 5-HT6 [ Show all ]
Disease	Migraine
Length	366
Amino acid sequence	MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
UniProt	P30939
Protein Data Bank	N/A
GPCR-HGmod model	P30939
3D structure model	This predicted structure model is from GPCR-EXP P30939.
BioLiP	N/A
Therapeutic Target Database	T78656
ChEMBL	CHEMBL1805
IUPHAR	5
DrugBank	BE0000460, BE0004958

Ligand

Name	CHEMBL322018
Molecular formula	C14H18N4O
IUPAC name	N-(3-piperidin-4-yl-1H-pyrrolo[3,2-b]pyridin-5-yl)acetamide
Molecular weight	258.325
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	0.7
Synonyms	SCHEMBL7005852 BDBM50130428 LXZJUOMETYSHFR-UHFFFAOYSA-N 5-(N-[acetyl]amino)-3-(piperidin-4-yl)pyrrolo[3,2-b]pyridine N-(3-Piperidin-4-yl-1H-pyrrolo[3,2-b]pyridin-5-yl)-acetamide
Inchi Key	LXZJUOMETYSHFR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H18N4O/c1-9(19)17-13-3-2-12-14(18-13)11(8-16-12)10-4-6-15-7-5-10/h2-3,8,10,15-16H,4-7H2,1H3,(H,17,18,19)
PubChem CID	10934159
ChEMBL	CHEMBL322018
IUPHAR	N/A
BindingDB	50130428
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	45.0 nM	PMID12825944	BindingDB,ChEMBL

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