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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1F
Species	Homo sapiens (Human)
Gene	HTR1F
Synonym	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled serotonin receptor 1F 5-HT-1F 5-HT1Ebeta HTR1EL 5-HT1F 5-HT1F receptor 5-HT6 [ Show all ]
Disease	Migraine
Length	366
Amino acid sequence	MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
UniProt	P30939
Protein Data Bank	N/A
GPCR-HGmod model	P30939
3D structure model	This predicted structure model is from GPCR-EXP P30939.
BioLiP	N/A
Therapeutic Target Database	T78656
ChEMBL	CHEMBL1805
IUPHAR	5
DrugBank	BE0000460, BE0004958

Ligand

Name	naratriptan
Molecular formula	C17H25N3O2S
IUPAC name	N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide
Molecular weight	335.466
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.0
Synonyms	AX8017803 CHEMBL1278 FC0032 N-methyl-2-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)ethane-1-sulfonamide Naramig (TN) NCGC00181786-04 AJ-08192 BDBM50073682 D08255 HY-B0197 N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]ethanesulfonamide Naratriptan [INN:BAN] SC-00604 AB01565792_02 Amerge, Naramig,Naratriptan AN-11431 CHEBI:7478 DB00952 LS-83062 N-Methyl-3-(1-methyl-4 -piperidinyl)-1H-indole-5-ethansulphonamide NCGC00181786-01 ZINC4076 2-[3-(1-Methyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide AC-5013 BC201774 Colatan FT-0656760 N-Methyl-2-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)ethanesulfonamide PubChem2191 AKOS015895854 Amerge;Naramig BIDD:GT0312 D0T3KI InChI=1/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethane-1-sulfonamide naratriptan; SCHEMBL68753 121679-13-8 AB2000122 API0005359 DTXSID7023354 N-methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulphonamide NCGC00181786-03 2578AH AC1L1I6A BCP9000978 CS-2131 GTPL45 N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide Naratriptan (INN) QX3KXL1ZA2 A25336 Amerge (TN) AMKVXSZCKVJAGH-UHFFFAOYSA-N C07792 L000432 N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide naratriptanum UNII-QX3KXL1ZA2 1H-Indole-5-ethanesulfonamide, N-methyl-3-(1-methyl-4-piperidinyl)- ABP000374 [ Show all ]
Inchi Key	AMKVXSZCKVJAGH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H3
PubChem CID	4440
ChEMBL	CHEMBL1278
IUPHAR	45
BindingDB	50073682
DrugBank	DB00952
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Ki	6.30957 nM	PMID15900510, PMID10193663	IUPHAR

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