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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1F
Species	Homo sapiens (Human)
Gene	HTR1F
Synonym	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled serotonin receptor 1F 5-HT-1F 5-HT1Ebeta HTR1EL 5-HT1F 5-HT1F receptor 5-HT6 [ Show all ]
Disease	Migraine
Length	366
Amino acid sequence	MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
UniProt	P30939
Protein Data Bank	N/A
GPCR-HGmod model	P30939
3D structure model	This predicted structure model is from GPCR-EXP P30939.
BioLiP	N/A
Therapeutic Target Database	T78656
ChEMBL	CHEMBL1805
IUPHAR	5
DrugBank	BE0000460, BE0004958

Ligand

Name	Dipropyl-5-CT
Molecular formula	C17H25N3O
IUPAC name	3-[2-(dipropylamino)ethyl]-1H-indole-5-carboxamide
Molecular weight	287.407
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.2
Synonyms	CHEMBL1332062 Lopac0_000408 NCGC00162145-01 SCHEMBL8891095 BDBM81789 DP-5-CT N,N-Dipropylcarboxamidotryptamine NSC_156314 1H-Indole-5-carboxamide, 3-(2-(dipropylamino)ethyl)- BRD-K32645441-001-01-4 CHEBI:92566 L000940 NCGC00015310-03 PDSP2_001246 D0D3PZ N,N-Dipropyl-5-carboxamidotryptamine NCGC00162145-02 ZINC2539820 Biomol-NT_000159 DP5CT NCGC00015310-01 PDSP1_001262 3-[2-(dipropylamino)ethyl]-1H-indole-5-carboxamide CAS_156314 Lopac-D-132 NCGC00015310-04 PDSP2_001599 AC1L4FYC N,N-Dipropyl-5-carboxamidotryptamine maleate NN-DIPROP-5-CT BPBio1_000662 CCG-204501 GTPL122 NCGC00015310-02 PDSP1_001615 74885-25-9 [ Show all ]
Inchi Key	DPXOFRGRKPFZOD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25N3O/c1-3-8-20(9-4-2)10-7-14-12-19-16-6-5-13(17(18)21)11-15(14)16/h5-6,11-12,19H,3-4,7-10H2,1-2H3,(H2,18,21)
PubChem CID	156314
ChEMBL	CHEMBL1332062
IUPHAR	122
BindingDB	81789
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1584.89 nM	PMID8380639	IUPHAR
Ki	1613.0 nM	PMID8380639	BindingDB

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