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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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Ligand

Name	VERAPAMIL
Molecular formula	C27H38N2O4
IUPAC name	2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
Molecular weight	454.611
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	3.8
Synonyms	1394-EP2298765A1 Cordilox 1394-EP2316832A1 CP-16533-1 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]methylamino}-2-(methy lethyl)pentanenitrile 7482-85-1 DSSTox_CID_21152 Akilen (Salt/Mix) Finoptin Apo-Verap HMS3402L15 Bio1_000425 BRD-A09533288-001-02-7 (2R)-2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile Calan 1394-EP2272972A1 CAS_52-53-9 STK538085 KB-243163 Veramex KBio3_000465 Verapamilo L001330 Verelan PM NCGC00016083-05 NCGC00016083-14 NCGC00024710-06 NSC 135784 Prestwick3_000141 SGTNSNPWRIOYBX-UHFFFAOYSA-N CCRIS 6749 1394-EP2301923A1 Covera-HS (Salt/Mix) 2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile CTK8D7130 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Dignover AB00053495-20 DTXSID9041152 alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile Geangin Benzeneacetonitrile, .alpha.-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)- IDI1_033983 Bio2_000233 BSPBio_001513 (R)-(+)-Verapamil Hydrochloride Calan SR 1394-EP2277865A1 Tox21_110300_1 KBio2_002343 Verapamil (USAN/INN) KBioGR_000233 Verapamilum [INN-Latin] LS-174 NCGC00016083-08 NCGC00016083-17 NCGC00024710-09 NSC_62969 SBI-0051204.P003 SPBio_002181 Isoptin (TN) 1394-EP2298742A1 CHEMBL6966 1394-EP2305648A1 CP 16533-1 (Verapamil) 2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]-2-isopropylpentanenitrile # D02356 52V114 dl-Verapamil AC1L1DV5 F2173-0851 Ansyr HMS1989L15 Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-, (+-)- Isoptin BP-21223 (+/-)-VERAPAMIL C07188 1394-EP2270011A1 Cardibeltin Isotopin Vasolan KBio2_005369 Verapamil [USAN:INN:BAN] KBioSS_000233 Verelan MolPort-000-721-258 NCGC00016083-11 NCGC00024710-04 NINDS_000399 Prestwick1_000141 SCHEMBL16742 Spectrum5_001786 CC-35584 1394-EP2298776A1 Cordilox (Salt/Mix) 1394-EP2316833A1 CP-165331 36622-29-4 DB00661 DSSTox_GSID_41152 AKOS005468962 FT-0080127 Arpamyl I06-0063 Bio1_000914 BRD-A09533288-003-05-6 (?)-alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile Calan (Salt/Mix) 1394-EP2272973A1 Tarka KBio1_000399 KBio3_000466 Verapamilo [INN-Spanish] Lekoptin Verexamil NCGC00016083-06 NCGC00016083-15 NCGC00024710-07 NSC 272306NA Quasar SMR001550201 CHEBI:77733 1394-EP2301931A1 Covera-hs (TN) 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-isopropyl-pentanenitrile D 365 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Dilacoran AB00053495_21 EINECS 200-145-1 alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile GTPL2406 Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino) propyl)-3,4-dimethoxy-alpha-(1-methylethyl)- Iproveratril Bio2_000713 (+-)-Verapamil BSPBio_002358 .alpha.-((N-Methyl-N-homoveratryl)-.gamma.-aminopropyl)-3,4-dimethoxyphenylacetonitrile Calcan 1394-EP2277872A1 Isoptin SR Univer KBio2_002801 Verapamil AL KBioGR_001372 Veraptin MCULE-3016077278 NCGC00016083-09 NCGC00016083-18 NCGC00344584-01 Nu-Verap SC-17292 Spectrum2_001740 1394-EP2298764A1 cMAP_000023 1394-EP2314585A1 CP-16,533-1 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile D0R0FE 56949-77-0 Drosteakard Akilen Falicard API0004584 HMS2089H17 Berkatens BPBio1_000268 (1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile C27H38N2O4 1394-EP2272841A1 CAS-52-53-9 Izoptin Veracim KBio2_007479 VERAPAMIL, Dexverapamil, Verapamyl hydrochloride, VERAPAMIL HYDROCHLORIDE KBioSS_002346 Verelan (TN) NCGC00016083-04 NCGC00016083-13 NCGC00024710-05 Novo-Veramil Prestwick2_000141 Securon ST50826367 CCG-205311 1394-EP2298779A1 Covera-HS 2-(3,4-Dimethoxyphenyl)-5-((2-(3,4-dimethoxyphenyl)ethyl)(methyl)amino)-2-isopropylpentanenitrile, (+/-)- CP-165331 / CP-16533-1 5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile delta-365 AB00053495 DSSTox_RID_79636 alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile FT-0603225 BDBM81939 IDI1_000399 Bio1_001403 BSPBio_000242 (A+/-)-Verapamil hydrochloride Calan (TN) 1394-EP2275420A1 Tox21_110300 KBio2_000233 Verapamil (Na-Ca chanel blocker) KBio3_002823 Verapamilum Lopac0_001237 Verpamil NCGC00016083-07 NCGC00016083-16 NCGC00024710-08 NSC272366 r,s-verapamil SPBio_001820 Isoptin (Salt/Mix) 1394-EP2280008A2 1394-EP2301936A1 CP 16533-1 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile D-365 52-53-9 DivK1c_000399 AC-16016 EINECS 260-462-6 AN-41629 HMS1791L15 Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)- Isoptimo Bosoptin (TN) (+/-) verapamil C-22537 1007128-78-0 Cardiagutt Isoptine Valeronitrile, 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropyl- KBio2_004911 Verapamil [USAN:BAN:INN] KBioGR_002343 vera\|A MLS006011414 NCGC00016083-10 NCGC00016083-20 NCI60_020143 Prestwick0_000141 SCHEMBL13287282 Spectrum4_000906 [ Show all ]
Inchi Key	SGTNSNPWRIOYBX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
PubChem CID	2520
ChEMBL	CHEMBL6966
IUPHAR	N/A
BindingDB	81939
DrugBank	DB00661
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
313945	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
313943	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
313950	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
313944	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
454158	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
551805	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
313941	Alpha-1B adrenergic receptor	P15823	Adra1b	Rattus norvegicus (Rat)	515
551804	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
551806	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572
313946	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
313949	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
313954	Beta-1 adrenergic receptor	Q28998	ADRB1	Sus scrofa (Pig)	468
313953	Beta-2 adrenergic receptor	Q28997	ADRB2	Sus scrofa (Pig)	418
313951	D(3) dopamine receptor	P35462	DRD3	Homo sapiens (Human)	400
313942	Glucagon-like peptide 1 receptor	P43220	GLP1R	Homo sapiens (Human)	463
313952	Histamine H2 receptor	P25021	HRH2	Homo sapiens (Human)	359
313948	Muscarinic acetylcholine receptor M2	P06199	CHRM2	Sus scrofa (Pig)	466

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