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Name | Muscarinic acetylcholine receptor M2 |
---|---|
Species | Sus scrofa (Pig) |
Gene | CHRM2 |
Synonym | N/A |
Disease | N/A for non-human GPCRs |
Length | 466 |
Amino acid sequence | MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR |
UniProt | P06199 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4781 |
IUPHAR | N/A |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
133 | CHEMBL169001 | C34H48N4O4+2 | 576.782 | 4 / 0 | 4.9 | No |
363 | CHEMBL31533 | C19H29N2O3+ | 333.452 | 3 / 1 | 2.6 | Yes |
6953 | CHEMBL609120 | C42H58N4O4 | 682.95 | 6 / 0 | 8.1 | No |
8906 | CHEMBL165814 | C30H40Br2N4O4 | 680.482 | 6 / 0 | N/A | No |
9573 | CHEMBL609125 | C46H54N4O4 | 726.962 | 6 / 0 | 8.4 | No |
12160 | CHEMBL8653 | C36H46Br2N4O4 | 758.596 | 6 / 0 | N/A | No |
12286 | CHEMBL607223 | C54H52Br2F6N4O2 | 1062.83 | 12 / 0 | N/A | No |
12287 | CHEMBL412670 | C54H52Br2F6N4O2 | 1062.83 | 12 / 0 | N/A | No |
12931 | CHEMBL1202152 | C19H25Br2Cl2N3O | 542.137 | 4 / 0 | N/A | No |
14723 | CHEMBL354103 | C39H40N6O6+2 | 688.785 | 8 / 0 | 4.8 | No |
17067 | CHEMBL285136 | C31H43N5O4+2 | 549.716 | 5 / 0 | 3.1 | No |
18057 | CHEMBL590603 | C29H26Br2Cl4N4O2 | 764.161 | 6 / 0 | N/A | No |
20797 | CHEMBL68151 | C38H60Br2N4O4 | 796.73 | 6 / 0 | N/A | No |
22759 | CHEMBL269205 | C36H46Br2N4O4 | 758.596 | 6 / 0 | N/A | No |
24628 | CHEMBL171664 | C36H34Br2N6O6 | 806.512 | 10 / 0 | N/A | No |
25656 | CHEMBL199636 | C35H50Br2N4O3 | 734.618 | 5 / 0 | N/A | No |
34543 | CHEMBL1202148 | C23H26Cl2N4O+2 | 445.388 | 3 / 0 | 4.9 | Yes |
34942 | N1-(3-(1,3-Dioxoisoindolin-2-yl)propyl)-N6-(4-(isoxazol-3-yloxy)but-2-ynyl)-N1,N1,N6,N6-tetramethylhexane-1,6-diaminium dibromide | C28H40Br2N4O4 | 656.46 | 7 / 0 | N/A | No |
36504 | CHEMBL330891 | C46H50Br2N4O2 | 850.74 | 6 / 0 | N/A | No |
37314 | CHEMBL1202149 | C22H23Br2Cl2N3O | 576.154 | 4 / 0 | N/A | No |
37893 | CHEMBL385915 | C60H60Cl2N6O6 | 1032.08 | 10 / 0 | N/A | No |
37894 | CHEMBL405305 | C60H60Cl2N6O6 | 1032.08 | 10 / 0 | N/A | No |
38233 | CHEMBL8518 | C38H50Br2N4O4 | 786.65 | 6 / 0 | N/A | No |
38802 | CHEMBL412718 | C56H62Cl2N4O6 | 958.034 | 10 / 0 | N/A | No |
38803 | CHEMBL607218 | C56H62Cl2N4O6 | 958.034 | 10 / 0 | N/A | No |
39665 | CHEMBL323853 | C35H41N7O4 | 623.758 | 7 / 2 | 3.8 | No |
39758 | CHEMBL412718 | C56H62N4O6+2 | 887.134 | 8 / 0 | 6.8 | No |
443357 | CHEMBL3337867 | C44H54Br2N4 | 798.752 | 4 / 0 | N/A | No |
42931 | Caracurine V | C38H40N4O2 | 584.764 | 6 / 0 | 3.9 | No |
42933 | CHEMBL312920 | C38H40N4O2 | 584.764 | 6 / 0 | 3.9 | No |
43195 | CHEMBL324318 | C50H58Br2N4O2 | 906.848 | 6 / 0 | N/A | No |
558699 | CHEMBL3121479 | C34H48N4O4+2 | 576.782 | 5 / 0 | 5.2 | No |
47257 | CHEMBL386134 | C52H44Br2F10N4O2 | 1106.74 | 16 / 0 | N/A | No |
49233 | CHEMBL30939 | C36H46N4O4+2 | 598.788 | 4 / 0 | 5.1 | No |
443658 | CHEMBL3355097 | C52H56Br2N6O5 | 1004.86 | 9 / 1 | N/A | No |
49584 | CHEMBL68151 | C38H60N4O4+2 | 636.922 | 4 / 0 | 5.5 | No |
52013 | CHEMBL1202149 | C22H23Cl2N3O+2 | 416.346 | 2 / 0 | 5.1 | No |
55969 | CHEMBL304129 | C36H56N4O4+2 | 608.868 | 4 / 0 | 4.6 | No |
64718 | CHEMBL286686 | C33H58N4O4+2 | 574.851 | 4 / 0 | 4.1 | No |
64719 | CHEMBL31097 | C33H58N4O4+2 | 574.851 | 4 / 0 | 4.1 | No |
64885 | CHEMBL3037938 | C54H58Cl2N4O4 | 897.982 | 8 / 0 | N/A | No |
66117 | CHEMBL168613 | C37H38N4O4+2 | 602.735 | 4 / 0 | 5.4 | No |
72045 | CHEMBL9017 | C34H42Br2F6N4O4 | 844.532 | 12 / 0 | N/A | No |
72434 | 13474-65-2 | C13H16N2O2 | 232.283 | 3 / 0 | 1.9 | Yes |
72959 | W-84 dibromide | C32H44Br2N4O4 | 708.536 | 6 / 0 | N/A | No |
78930 | CHEMBL303052 | C38H60Br2N4O2S2 | 828.852 | 6 / 0 | N/A | No |
80126 | CHEMBL9071 | C36H52Br2N4O4 | 764.644 | 6 / 0 | N/A | No |
82081 | CHEMBL304129 | C36H56Br2N4O4 | 768.676 | 6 / 0 | N/A | No |
83315 | CHEMBL265482 | C46H60N4O2+2 | 701.012 | 2 / 0 | 7.9 | No |
86827 | CHEMBL285811 | C33H46N4O4+2 | 562.755 | 4 / 0 | 4.2 | No |
87428 | CHEMBL382659 | C31H46Br2N4O3 | 682.542 | 5 / 0 | N/A | No |
88355 | AC1L8OQE | C36H46N4O4+2 | 598.788 | 4 / 0 | 5.1 | No |
89099 | CHEMBL405691 | C52H52N6O6+2 | 857.024 | 8 / 0 | 6.6 | No |
96301 | CHEMBL406431 | C39H52Br2N4O4 | 800.677 | 6 / 0 | N/A | No |
98914 | CHEMBL275988 | C30H42Br2N6O4 | 710.512 | 8 / 0 | N/A | No |
102580 | CHEMBL264005 | C31H42Br2N4O4 | 694.509 | 6 / 4 | N/A | No |
560542 | CHEMBL3121478 | C32H44N4O4+2 | 548.728 | 5 / 0 | 4.1 | No |
104939 | CHEMBL331543 | C44H50Br2N4O2 | 826.718 | 6 / 1 | N/A | No |
109829 | CHEMBL169342 | C33H28Br2N6O6 | 764.431 | 10 / 0 | N/A | No |
112126 | CHEMBL73114 | C34H52N4O4+2 | 580.814 | 4 / 0 | 3.9 | No |
112292 | CHEMBL31221 | C27H50N4O4+2 | 494.721 | 4 / 0 | 2.0 | Yes |
115227 | CID 44400979 | C34H48Br2N4O4 | 736.59 | 6 / 2 | N/A | No |
118240 | CHEMBL352356 | C33H30N4O4+2 | 546.627 | 4 / 0 | 4.0 | No |
121189 | CHEMBL354673 | C35H34Br2N4O4 | 734.489 | 6 / 0 | N/A | No |
122578 | CHEMBL540132 | C42H65ClN6O4+2 | 753.47 | 6 / 3 | 7.8 | No |
123530 | CHEMBL284962 | C41H52N4O4+2 | 664.891 | 4 / 0 | 5.2 | No |
555987 | 4-Diphenylacetoxy-1,1-dimethylpiperidinium | C21H26NO2+ | 324.444 | 2 / 0 | 4.0 | Yes |
129370 | CHEMBL33656 | C23H24Cl2N4O2+2 | 459.371 | 4 / 0 | 4.8 | Yes |
130045 | CHEMBL68936 | C46H56N4O2+2 | 696.98 | 2 / 0 | 8.2 | No |
130046 | CHEMBL2111531 | C46H56N4O2+2 | 696.98 | 2 / 0 | 8.2 | No |
130047 | CHEMBL31376 | C46H56N4O2+2 | 696.98 | 2 / 0 | 8.2 | No |
130382 | CHEMBL169475 | C37H36N6O6+2 | 660.731 | 8 / 0 | 4.1 | No |
132911 | CHEMBL353262 | C29H38Br2N4O4 | 666.455 | 6 / 0 | N/A | No |
133430 | CHEMBL433343 | C44H46N4O2+2 | 662.878 | 4 / 0 | 4.2 | No |
446996 | CHEMBL3337863 | C44H54Br2N4O | 814.751 | 5 / 1 | N/A | No |
136117 | CHEMBL8721 | C41H56Br2N4O4 | 828.731 | 6 / 0 | N/A | No |
138548 | CHEMBL609382 | C40H54N4O4 | 654.896 | 6 / 0 | 7.4 | No |
138657 | CHEMBL407071 | C52H52Br2N4O2+2 | 924.822 | 4 / 0 | 8.3 | No |
139097 | CHEMBL177732 | C28H44N4O4+2 | 500.684 | 4 / 0 | 2.1 | No |
447283 | CHEMBL3337859 | C43H48Br2N4O2 | 812.691 | 6 / 0 | N/A | No |
142131 | CHEMBL311649 | C44H50Br2N4O2 | 826.718 | 6 / 0 | N/A | No |
142132 | diallylcaracurie V | C44H50Br2N4O2 | 826.718 | 6 / 0 | N/A | No |
144360 | CHEMBL2311018 | C52H54N4O2+2 | 767.03 | 4 / 0 | 7.0 | No |
147865 | CHEMBL386112 | C60H58Br2N4O2 | 1026.96 | 6 / 0 | N/A | No |
147866 | CHEMBL407440 | C60H58Br2N4O2 | 1026.96 | 6 / 0 | N/A | No |
561913 | CHEMBL3121480 | C33H44N4O4+2 | 560.739 | 5 / 0 | 4.3 | No |
148247 | Dimethyl-W84 dibromide | C34H48Br2N4O4 | 736.59 | 6 / 0 | N/A | No |
148617 | CHEMBL31385 | C25H46N4O4+2 | 466.667 | 4 / 0 | 0.9 | Yes |
149156 | CHEMBL168760 | C31H42N4O4+2 | 534.701 | 4 / 0 | 3.5 | No |
153053 | CHEMBL194935 | C32H44Br2N4O4 | 708.536 | 6 / 4 | N/A | No |
158635 | CHEMBL8764 | C42H52Br2N4O4 | 836.71 | 6 / 0 | N/A | No |
159180 | CHEMBL171215 | C24H26BrN3O4 | 500.393 | 5 / 0 | N/A | No |
160201 | CHEMBL325938 | C24H32N6O2 | 436.56 | 5 / 3 | 1.5 | Yes |
162659 | CHEMBL303002 | C32H48N4O2+2 | 520.762 | 2 / 0 | 3.9 | No |
448190 | CHEMBL3337865 | C38H44N4 | 556.798 | 4 / 0 | 5.6 | No |
166739 | CHEMBL352486 | C36H36N4O4+2 | 588.708 | 4 / 0 | 4.9 | No |
170009 | CHEMBL352323 | C36H52Br2N4O4 | 764.644 | 6 / 0 | N/A | No |
174993 | CHEMBL607222 | C54H54Br2N4O4 | 982.858 | 8 / 0 | N/A | No |
177874 | CHEMBL171776 | C34H32N4O4+2 | 560.654 | 4 / 0 | 4.2 | No |
181283 | CHEMBL274564 | C40H54Br2N4O4 | 814.704 | 6 / 0 | N/A | No |
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