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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Sus scrofa (Pig)
Gene	CHRM2
Synonym	N/A
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P06199
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4781
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL325938
Molecular formula	C24H32N6O2
IUPAC name	6-oxo-N-[2-[2-(propylaminomethyl)piperidin-1-yl]ethyl]-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Molecular weight	436.56
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	1.5
Synonyms	N-[2-[2-(Propylaminomethyl)piperidino]ethyl]-6-oxo-5,6-dihydro-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Inchi Key	JUKDBYFHSWPKBN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H32N6O2/c1-2-12-25-17-18-8-5-6-15-29(18)16-14-27-24(32)30-21-11-4-3-9-19(21)23(31)28-20-10-7-13-26-22(20)30/h3-4,7,9-11,13,18,25H,2,5-6,8,12,14-17H2,1H3,(H,27,32)(H,28,31)
PubChem CID	12179434
ChEMBL	CHEMBL325938
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Emax,diss	76.0 %	PMID15163212	ChEMBL
Palpha	-1.8 -	PMID15163212	ChEMBL
pEC0.5,diss	4.95 -	PMID15163212	ChEMBL
pKA	8.01 -	PMID15163212	ChEMBL

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