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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesSus scrofa (Pig)
GeneCHRM2
SynonymN/A
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP06199
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4781
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL352356
Molecular formulaC33H30N4O4+2
IUPAC name2-[2-[4-[3-[1-[2-(1,3-dioxoisoindol-2-yl)ethyl]pyridin-1-ium-4-yl]propyl]pyridin-1-ium-1-yl]ethyl]isoindole-1,3-dione
Molecular weight546.627
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.0
SynonymsCHEMBL1184494
2-(4-{3-[1-(1,3-dioxo-2,3-dihydro-1H-2-isoindolylmethyl)-4-pyridiniumyl]propyl}-1-pyridiniumylmethyl)-1,3-isoindolinedione; dibromide
BDBM50074570
4,4'-Trimethylenebis[1-(2-phthalimidylethyl)pyridinium]
Inchi KeyHLUKJECPCWDFDB-UHFFFAOYSA-N
Inchi IDInChI=1S/C33H30N4O4/c38-30-26-8-1-2-9-27(26)31(39)36(30)22-20-34-16-12-24(13-17-34)6-5-7-25-14-18-35(19-15-25)21-23-37-32(40)28-10-3-4-11-29(28)33(37)41/h1-4,8-19H,5-7,20-23H2/q+2
PubChem CID10556700
ChEMBLN/A
IUPHARN/A
BindingDB50074570
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC503490.0 nMPMID10072682BindingDB

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