Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Vasoactive intestinal polypeptide receptor 1
Species	Homo sapiens (Human)
Gene	VIPR1
Synonym	VPAC1 VIP-R-1 VIP and PACAP receptor 1 VIP-R1 RDC1 PVR2 pituitary adenylate cyclase-activating polypeptide type II receptor PACAP-R2 PACAP-R-2 PACAP type II receptor HVR1 VPAC1 receptor [ Show all ]
Disease	Respiratory disease Chronic obstructive pulmonary disease; Pulmonary arterial hypertension
Length	457
Amino acid sequence	MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
UniProt	P32241
Protein Data Bank	N/A
GPCR-HGmod model	P32241
3D structure model	This predicted structure model is from GPCR-EXP P32241.
BioLiP	N/A
Therapeutic Target Database	T86364
ChEMBL	CHEMBL5144
IUPHAR	371
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
522107	CHEMBL3775436	C15H26ClNO3	303.827	4 / 3	N/A	N/A
522191	CHEMBL3775769	C15H26ClNO3	303.827	4 / 3	N/A	N/A
27193	CHEMBL2203713	C18H22N4S	326.462	4 / 2	2.9	Yes
33505	UNII-7W7511NPF8	C20H20N2O3S	368.451	6 / 1	1.8	Yes
555672	BDBM86050	C159H258N46O47S	3598.15	56 / 53	-18.9	No
64647	MK 0893	C32H27Cl2N3O4	588.485	5 / 2	6.8	No
93901	CID 16214685	C142H223N39O40S	3148.64	48 / 48	-12.0	No
524288	SCHEMBL2101506	C21H20ClFN2O4	418.849	5 / 3	2.3	Yes
555900	BDBM86051	C144H244N44O38	3199.81	46 / 47	-11.8	No
112979	BDBM50435130	C147H238N44O42S	3325.85	50 / 49	-15.0	No
525161	CID 44139848	C148H228N40O39S	3223.75	47 / 48	-8.7	No
134584	Benzthiazole compound, 33p	C21H23N3O3S	397.493	6 / 2	3.3	Yes
138691	PHA-543613	C15H17N3O2	271.32	4 / 1	1.5	Yes
448286	CHEMBL3334797	C15H22Cl2N2O	317.254	3 / 0	3.1	Yes
554144	Secrepan	C130H219N43O42	3056.44	48 / 52	-13.4	No
176140	CHEMBL2326501	C24H33N3O3	411.546	5 / 2	5.4	No
540789	CHEMBL3883366	C13H17NO2	219.284	2 / 2	1.7	Yes
550256	CHEMBL3884667	C148H240N44O42	3307.81	49 / 51	-13.6	No
224266	CHEMBL2206397	C14H18N2	214.312	1 / 1	3.6	Yes
529042	CHEMBL3736134	C150H227FN40O39S	3265.76	48 / 48	-8.2	No
543145	NSC157267	C13H16ClNO2	253.726	2 / 2	2.3	Yes
267978	CHEMBL1807053	C19H24F3N3O3	399.414	9 / 1	5.5	No
270115	CHEMBL2392692	C19H22BrF3N6O2	503.324	10 / 2	4.3	No
530208	PACAP 1-27	C142H224N40O39S	3147.66	47 / 48	-10.3	No
554791	pituitary adenylate cyclase activating polypeptide-27	C142H224N40O39S	3147.66	47 / 48	-10.3	No
554868	Helodermin	C176H285N47O49	3843.5	55 / 53	-9.7	No
544730	BRN 2263667	C12H14ClNO2	239.699	2 / 2	2.0	Yes
330304	CHEMBL2087421	C24H40N4O5S	496.667	8 / 0	1.6	Yes
530924	CHEMBL3736230	C150H228N40O39S	3247.77	47 / 48	-8.3	No
335809	AKOS024456450	C203H331N63O53S	4534.33	67 / 72	-16.6	No
351171	CHEMBL525028	C147H237N43O43S	3326.83	51 / 51	-15.9	No
555039	BDBM81828	C147H237N43O43S	3326.83	51 / 49	-16.6	No
376302	Ro-85	C22H27N5O2S	425.551	5 / 1	2.6	Yes
429496	JNJ-10392980	C20H22N2O3	338.407	5 / 0	4.5	Yes
434334	Prucalopride	C18H26ClN3O3	367.874	5 / 2	2.0	Yes
436937	CHEMBL2391147	C13H16N2O2	232.283	2 / 1	0.6	Yes
557287	339071-18-0	C11H14ClN3O2	255.702	4 / 2	1.3	Yes

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417