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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Vasoactive intestinal polypeptide receptor 1
Species	Homo sapiens (Human)
Gene	VIPR1
Synonym	VPAC1 VIP-R-1 VIP and PACAP receptor 1 VIP-R1 RDC1 PVR2 pituitary adenylate cyclase-activating polypeptide type II receptor PACAP-R2 PACAP-R-2 PACAP type II receptor HVR1 VPAC1 receptor [ Show all ]
Disease	Respiratory disease Chronic obstructive pulmonary disease; Pulmonary arterial hypertension
Length	457
Amino acid sequence	MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
UniProt	P32241
Protein Data Bank	N/A
GPCR-HGmod model	P32241
3D structure model	This predicted structure model is from GPCR-EXP P32241.
BioLiP	N/A
Therapeutic Target Database	T86364
ChEMBL	CHEMBL5144
IUPHAR	371
DrugBank	N/A

Ligand

Name	CHEMBL2326501
Molecular formula	C24H33N3O3
IUPAC name	(3-piperazin-1-ylphenyl) N-(4-heptoxyphenyl)carbamate
Molecular weight	411.546
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.4
Synonyms	BDBM50426687
Inchi Key	KRCLPAGVJVBLJR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H33N3O3/c1-2-3-4-5-6-18-29-22-12-10-20(11-13-22)26-24(28)30-23-9-7-8-21(19-23)27-16-14-25-15-17-27/h7-13,19,25H,2-6,14-18H2,1H3,(H,26,28)
PubChem CID	71541072
ChEMBL	CHEMBL2326501
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	-1.0 %	PMID23237837	ChEMBL

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