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GLASS

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GPCR

Name	Vasoactive intestinal polypeptide receptor 1
Species	Homo sapiens (Human)
Gene	VIPR1
Synonym	VPAC1 VIP-R-1 VIP and PACAP receptor 1 VIP-R1 RDC1 PVR2 pituitary adenylate cyclase-activating polypeptide type II receptor PACAP-R2 PACAP-R-2 PACAP type II receptor HVR1 VPAC1 receptor [ Show all ]
Disease	Respiratory disease Chronic obstructive pulmonary disease; Pulmonary arterial hypertension
Length	457
Amino acid sequence	MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
UniProt	P32241
Protein Data Bank	N/A
GPCR-HGmod model	P32241
3D structure model	This predicted structure model is from GPCR-EXP P32241.
BioLiP	N/A
Therapeutic Target Database	T86364
ChEMBL	CHEMBL5144
IUPHAR	371
DrugBank	N/A

Ligand

Name	339071-18-0
Molecular formula	C11H14ClN3O2
IUPAC name	N'-(3-chloro-4-morpholin-4-ylphenyl)-N-hydroxymethanimidamide
Molecular weight	255.702
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.3
Synonyms	D09LKR N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide TS-011 AK-59782 HY-15603 CS-0007825 MolPort-044-723-707 DS-16349 N-(3-Chloro-4-morpholinophenyl)-N-hydroxyformimidamide ZINC6746071 AKOS022180267 Methanimidamide, N-[3-chloro-4-(4-morpholinyl)phenyl]-N'-hydroxy- (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide CTK1B8099 N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyformamidine AJ-56824 DTXSID00431234 SCHEMBL3983851 BDBM86694 MolPort-035-681-438 [ Show all ]
Inchi Key	ZTXADXBIGLLOFX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14)
PubChem CID	9816527
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86694
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID15831442	BindingDB

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