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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasoactive intestinal polypeptide receptor 1
Species	Homo sapiens (Human)
Gene	VIPR1
Synonym	VPAC1 VIP-R-1 VIP and PACAP receptor 1 VIP-R1 RDC1 PVR2 pituitary adenylate cyclase-activating polypeptide type II receptor PACAP-R2 PACAP-R-2 PACAP type II receptor HVR1 VPAC1 receptor [ Show all ]
Disease	Respiratory disease Chronic obstructive pulmonary disease; Pulmonary arterial hypertension
Length	457
Amino acid sequence	MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
UniProt	P32241
Protein Data Bank	N/A
GPCR-HGmod model	P32241
3D structure model	This predicted structure model is from GPCR-EXP P32241.
BioLiP	N/A
Therapeutic Target Database	T86364
ChEMBL	CHEMBL5144
IUPHAR	371
DrugBank	N/A

Ligand

Name	CHEMBL3775769
Molecular formula	C15H26ClNO3
IUPAC name	(2S)-2-[2-[2-(2,6-dimethylphenoxy)ethoxy]ethylamino]propan-1-ol;hydrochloride
Molecular weight	303.827
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	None
Synonyms	SCHEMBL16445956
Inchi Key	BFBVSDYKRDBSFJ-UQKRIMTDSA-N
Inchi ID	InChI=1S/C15H25NO3.ClH/c1-12-5-4-6-13(2)15(12)19-10-9-18-8-7-16-14(3)11-17;/h4-6,14,16-17H,7-11H2,1-3H3;1H/t14-;/m0./s1
PubChem CID	117858131
ChEMBL	CHEMBL3775769
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	-17.8 %	PMID26988801	ChEMBL

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