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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasoactive intestinal polypeptide receptor 1
Species	Homo sapiens (Human)
Gene	VIPR1
Synonym	VPAC1 VIP-R-1 VIP and PACAP receptor 1 VIP-R1 RDC1 PVR2 pituitary adenylate cyclase-activating polypeptide type II receptor PACAP-R2 PACAP-R-2 PACAP type II receptor HVR1 VPAC1 receptor [ Show all ]
Disease	Respiratory disease Chronic obstructive pulmonary disease; Pulmonary arterial hypertension
Length	457
Amino acid sequence	MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
UniProt	P32241
Protein Data Bank	N/A
GPCR-HGmod model	P32241
3D structure model	This predicted structure model is from GPCR-EXP P32241.
BioLiP	N/A
Therapeutic Target Database	T86364
ChEMBL	CHEMBL5144
IUPHAR	371
DrugBank	N/A

Ligand

Name	CHEMBL3334797
Molecular formula	C15H22Cl2N2O
IUPAC name	3-(3,4-dichlorophenyl)-N,N-dimethyl-3-morpholin-4-ylpropan-1-amine
Molecular weight	317.254
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.1
Synonyms	BDBM50098893 SCHEMBL14775025
Inchi Key	KEGBICCDHKITSP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H22Cl2N2O/c1-18(2)6-5-15(19-7-9-20-10-8-19)12-3-4-13(16)14(17)11-12/h3-4,11,15H,5-10H2,1-2H3
PubChem CID	54767240
ChEMBL	CHEMBL3334797
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	2.2 %	PMID25164761	ChEMBL

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