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Name | Alpha-1B adrenergic receptor |
---|---|
Species | Mesocricetus auratus (Golden hamster) |
Gene | ADRA1B |
Synonym | Alpha-1B adrenoceptor Alpha-1B adrenoreceptor |
Disease | N/A for non-human GPCRs |
Length | 515 |
Amino acid sequence | MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF |
UniProt | P18841 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3122 |
IUPHAR | N/A |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
1126 | CHEMBL287965 | C24H24N4O3S | 448.541 | 6 / 1 | 3.1 | Yes |
1636 | CHEMBL1259079 | C26H28N2S | 400.584 | 3 / 0 | 5.7 | No |
6838 | CHEMBL1259231 | C23H26N4S | 390.549 | 4 / 0 | 3.7 | Yes |
8113 | CHEMBL317333 | C26H24FN5 | 425.511 | 5 / 0 | 4.0 | Yes |
8311 | CHEMBL1259080 | C27H30N2S | 414.611 | 3 / 0 | 6.1 | No |
8899 | Ethanesulfonamide, N-[3-(3-pyrrolidinyl)phenyl]- | C12H18N2O2S | 254.348 | 4 / 2 | 1.0 | Yes |
11102 | CHEMBL2261352 | C14H18N4O2 | 274.324 | 3 / 4 | 0.0 | Yes |
14972 | CHEMBL434591 | C25H25N3O3S | 447.553 | 5 / 1 | 4.2 | Yes |
15924 | CHEMBL40819 | C25H24N4O5S | 492.55 | 7 / 1 | 4.0 | Yes |
19611 | CHEMBL327116 | C15H19N3O2S | 305.396 | 4 / 2 | 2.1 | Yes |
21541 | CHEMBL40780 | C26H24N4O3S | 472.563 | 6 / 1 | 3.9 | Yes |
23011 | CHEMBL417890 | C25H25N3O4 | 431.492 | 5 / 1 | 3.5 | Yes |
26586 | Yohimbine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
30252 | CHEMBL111372 | C14H17N3O3S | 307.368 | 5 / 3 | 1.4 | Yes |
37833 | CHEMBL327527 | C27H30FN7O | 487.583 | 5 / 1 | 3.2 | Yes |
44148 | CHEMBL1259158 | C25H33N3OS | 423.619 | 4 / 1 | 4.2 | Yes |
63152 | (-)-Norephedrine | C9H13NO | 151.209 | 2 / 2 | 0.8 | Yes |
63183 | phenylpropanolamine | C9H13NO | 151.209 | 2 / 2 | 0.8 | Yes |
66968 | TAMSULOSIN | C20H28N2O5S | 408.513 | 7 / 2 | 2.7 | Yes |
67822 | CHEMBL324238 | C13H15N3O3S | 293.341 | 5 / 2 | 0.3 | Yes |
68313 | CHEMBL40754 | C24H24N4O3S | 448.541 | 6 / 1 | 3.1 | Yes |
69394 | CHEMBL328187 | C27H30FN7O | 487.583 | 5 / 1 | 2.9 | Yes |
69949 | CHEMBL93923 | C28H31FN6O | 486.595 | 4 / 1 | 3.4 | Yes |
70960 | CHEMBL2261355 | C15H19N3O2S | 305.396 | 4 / 2 | 2.1 | Yes |
70963 | CHEMBL111496 | C15H19N3O2S | 305.396 | 4 / 2 | 2.1 | Yes |
73680 | CHEMBL41234 | C25H26N4O4S | 478.567 | 7 / 1 | 3.5 | Yes |
73853 | CHEMBL289437 | C24H23ClN4O3S | 482.983 | 6 / 1 | 3.8 | Yes |
76960 | SCHEMBL8856947 | C15H21N3O3S | 323.411 | 5 / 2 | 0.7 | Yes |
77778 | CHEMBL1259188 | C27H31FN8O | 502.598 | 6 / 1 | 3.6 | No |
87183 | SCHEMBL7097480 | C14H17N3O2S | 291.369 | 4 / 2 | 1.7 | Yes |
87189 | CHEMBL111554 | C14H17N3O2S | 291.369 | 4 / 2 | 1.7 | Yes |
87887 | CHEMBL1259062 | C26H28N2S | 400.584 | 3 / 0 | 5.7 | No |
88008 | CHEMBL420997 | C25H25FN6 | 428.515 | 5 / 0 | 3.8 | Yes |
88075 | CHEMBL111463 | C15H19N3O2S | 305.396 | 4 / 1 | 1.9 | Yes |
88222 | CHEMBL1259042 | C23H24N4S | 388.533 | 5 / 0 | 3.6 | Yes |
97600 | SB 242084 | C21H19ClN4O2 | 394.859 | 4 / 1 | 3.8 | Yes |
101834 | CHEMBL288530 | C23H23N5O3S | 449.529 | 7 / 1 | 2.4 | Yes |
109155 | SERTINDOLE | C24H26ClFN4O | 440.947 | 3 / 1 | 4.1 | Yes |
112918 | CHEMBL290387 | C23H22ClN5O3S | 483.971 | 7 / 1 | 3.4 | Yes |
115728 | 5-Methylurapidil | C21H31N5O3 | 401.511 | 6 / 1 | 1.9 | Yes |
119776 | CHEMBL43234 | C26H24F3N3O3S | 515.551 | 8 / 1 | 5.0 | No |
127675 | CHEMBL320353 | C11H13N3O2S2 | 283.364 | 5 / 2 | 1.8 | Yes |
127714 | Ethanesulfonamide, N-[3-(1H-imidazol-4-ylmethyl)-2-methylphenyl]- | C13H17N3O2S | 279.358 | 4 / 2 | 1.7 | Yes |
131360 | prazosin | C19H21N5O4 | 383.408 | 8 / 1 | 2.0 | Yes |
138400 | CHEMBL419369 | C14H22N2O2S | 282.402 | 4 / 2 | 1.8 | Yes |
139179 | CHEMBL2261354 | C15H21N3O3S | 323.411 | 5 / 2 | 0.6 | Yes |
141173 | CHEMBL322492 | C15H19N3O2S | 305.396 | 4 / 2 | 2.3 | Yes |
142400 | CHEMBL43573 | C27H27N3O5S | 505.589 | 7 / 1 | 4.0 | No |
143487 | CHEMBL111682 | C12H15N3O2S | 265.331 | 4 / 2 | 1.3 | Yes |
149673 | CHEMBL2261348 | C16H23N3O3S | 337.438 | 5 / 3 | 1.3 | Yes |
447698 | SCHEMBL7098572 | C14H15N3O2S | 289.353 | 4 / 2 | 1.3 | Yes |
153542 | CHEMBL1259005 | C24H26N2S2 | 406.606 | 4 / 0 | 5.4 | No |
159108 | CHEMBL40564 | C26H27N3O3S | 461.58 | 5 / 1 | 4.5 | Yes |
159381 | CHEMBL1259113 | C20H25N3S | 339.501 | 4 / 1 | 2.6 | Yes |
162147 | isoproterenol | C11H17NO3 | 211.261 | 4 / 4 | -0.6 | Yes |
162637 | CHEMBL1259063 | C26H28N2S | 400.584 | 3 / 0 | 5.7 | No |
164616 | CHEMBL320765 | C16H21N3O2S | 319.423 | 4 / 2 | 2.5 | Yes |
167006 | CHEMBL1259187 | C27H32FN5O2 | 477.584 | 4 / 2 | 2.6 | Yes |
169330 | CHEMBL1259023 | C24H25N3S | 387.545 | 4 / 0 | 4.3 | Yes |
173479 | CHEMBL313424 | C27H29FN6O2 | 488.567 | 6 / 0 | 3.8 | Yes |
174094 | CHEMBL323440 | C15H19N3O2S | 305.396 | 4 / 2 | 2.1 | Yes |
174719 | CHEMBL323004 | C15H18ClN3O2S | 339.838 | 4 / 2 | 2.7 | Yes |
175844 | CHEMBL1259097 | C27H30N2S | 414.611 | 3 / 0 | 6.1 | No |
187142 | CHEMBL111391 | C16H21N3O2S | 319.423 | 4 / 2 | 2.6 | Yes |
187625 | CHEMBL2261347 | C15H21N3O3S | 323.411 | 5 / 3 | 0.8 | Yes |
189546 | CHEMBL109755 | C14H19N3O2S | 293.385 | 4 / 2 | 0.8 | Yes |
194470 | A 61603 HYDROBROMIDE | C14H20BrN3O3S | 390.296 | 5 / 4 | N/A | N/A |
199747 | CHEMBL111584 | C15H19N3O2S | 305.396 | 4 / 1 | 1.7 | Yes |
205415 | CHEMBL1259043 | C25H26N2S | 386.557 | 3 / 0 | 5.3 | No |
207851 | CHEMBL1258987 | C23H26N4S | 390.549 | 4 / 0 | 3.6 | Yes |
212191 | AC1NKXXY | C17H19N3O | 281.359 | 2 / 2 | 3.3 | Yes |
212414 | CHEMBL288678 | C23H23N5O3S | 449.529 | 7 / 1 | 2.8 | Yes |
212999 | CHEMBL2261349 | C14H16F3N3O3S | 363.355 | 8 / 3 | 1.6 | Yes |
214317 | CHEMBL442394 | C15H19N3O3S | 321.395 | 5 / 2 | 1.7 | Yes |
218774 | CHEMBL111537 | C16H21N3O2S | 319.423 | 4 / 2 | 2.5 | Yes |
219240 | CHEMBL110860 | C11H13N3O4S2 | 315.362 | 6 / 2 | 0.5 | Yes |
223178 | CHEMBL1259217 | C21H24N6S | 392.525 | 6 / 0 | 3.0 | Yes |
226126 | CHEMBL97333 | C29H33FN6O | 500.622 | 5 / 0 | 4.0 | No |
233957 | CHEMBL111151 | C13H15N3O3S | 293.341 | 5 / 2 | 0.9 | Yes |
240669 | CHEMBL41444 | C25H24ClN3O3S | 481.995 | 5 / 1 | 4.8 | Yes |
242378 | CHEMBL2261350 | C19H21N3O3S | 371.455 | 5 / 3 | 2.0 | Yes |
244522 | A-131701 | C24H24N4O3S | 448.541 | 6 / 1 | 3.2 | Yes |
247700 | Tocris-1052 | C14H19N3O3S | 309.384 | 5 / 3 | 0.4 | Yes |
247706 | CHEMBL133451 | C14H19N3O3S | 309.384 | 5 / 3 | 0.4 | Yes |
247716 | A61603 | C14H19N3O3S | 309.384 | 5 / 3 | 0.4 | Yes |
254649 | CHEMBL291073 | C26H26N4O4S | 490.578 | 6 / 2 | 3.0 | Yes |
255098 | CHEMBL290388 | C26H26N4O4S | 490.578 | 6 / 2 | 3.0 | Yes |
256039 | CHEMBL1259172 | C25H30FN5O | 435.547 | 4 / 2 | 2.3 | Yes |
260875 | CHEMBL111771 | C14H17N3O2S | 291.369 | 4 / 2 | 1.5 | Yes |
261556 | CHEMBL289758 | C27H29N3O3S | 475.607 | 5 / 1 | 4.9 | Yes |
266557 | CHEMBL111536 | C15H19N3O2S | 305.396 | 4 / 1 | 1.7 | Yes |
267428 | CHEMBL1259112 | C20H21N3S | 335.469 | 4 / 0 | 3.4 | Yes |
274076 | CHEMBL109827 | C15H17N3O2 | 271.32 | 3 / 2 | 2.3 | Yes |
277210 | CHEMBL111685 | C21H29N3O2S | 387.542 | 4 / 2 | 4.6 | Yes |
278014 | CHEMBL110976 | C15H19N3O3S | 321.395 | 5 / 2 | 1.7 | Yes |
278479 | CHEMBL2326175 | C23H24FN5 | 389.478 | 4 / 0 | 4.1 | Yes |
278929 | CHEMBL1259006 | C24H25N3S | 387.545 | 4 / 0 | 4.3 | Yes |
284339 | CHEMBL43909 | C29H27N5O3S | 525.627 | 7 / 1 | 4.1 | No |
284592 | CHEMBL320589 | C11H13N3O2S | 251.304 | 4 / 2 | 1.1 | Yes |
286737 | CHEMBL289627 | C26H24N4O3S | 472.563 | 6 / 1 | 3.9 | Yes |
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