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GPCR

Name	Alpha-1B adrenergic receptor
Species	Mesocricetus auratus (Golden hamster)
Gene	ADRA1B
Synonym	Alpha-1B adrenoceptor Alpha-1B adrenoreceptor
Disease	N/A for non-human GPCRs
Length	515
Amino acid sequence	MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF
UniProt	P18841
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3122
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	(-)-Norephedrine
Molecular formula	C9H13NO
IUPAC name	(1R,2S)-2-amino-1-phenylpropan-1-ol
Molecular weight	151.209
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	0.8
Synonyms	KBio2_006719 (1R,2S)-2-Amino-1-phenyl-1-propanol LS-97284 (R,S)-(1)-alpha-(1-Aminoethyl)benzyl alcohol NSC-17704 1-Propanol, 2-amino-1-phenyl-, (-)- Phenylpropanolamine (VAN) 57B9YG5Y1E Spectrum3_000889 API0017708 UNII-33RU150WUN component DLNKOYKMWOXYQA-CBAPKCEASA-N Benzyl alcohol, alpha-(1-aminoethyl)- CHEBI:80680 EINECS 207-755-7 Fenilpropanolamina [Italian] (-)-Phenylpropanolamine (1R,2S)- Norephedrine KBioSS_001583 (1R,2S)-2-amino-1-phenylpropan-1-ol NOREPHEDRINE, (-)- (\|AR)-\|A-[(1S)-1-Aminoethyl]benzenemethanol PDSP2_001333 14838-15-4 Phenylpropanolaminum [INN-Latin] AB1001936 Spectrum_001103 Benzenemethanol, alpha-((1S)-1-aminoethyl)-, (alphaR)- USAF CS-6 BRN 3196918 D08368 erythro-(1R,2S)-Norephedrine (+-)-Phenylpropanolamine HSDB 6485 (1R,2S)-(-)-Norephedrine, 99% l-Norephedrine (1s,2r)-2-hydroxy-2-phenyl-1-methyl-1-aminoethane NSC 17704 1-norephedrine phenylpropanolamine 4-13-00-01875 (Beilstein Handbook Reference) SPBio_000051 AN-45282 SR-05000001534-2 Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R,S))- X-3479 C9H13NO dl-Phenylpropanolamine FCH3409240 (-)-Norephedrin KBio2_001583 KBio3_001778 (1R,2S)-2-Amino-1-phenyl-1-propanol; L-(-)-Norephedrine Mydriatin (R,S)-(-)-Norephedrine NSC17704 1-Propanol, 2-amino-1-phenyl-, (-)- (9CI) Phenylpropanolamine [INN:BAN] 700-65-2 Spectrum4_000983 Benzenemethanol, .alpha.-(1-aminoethyl)-, [R-(R,S)]- UNII-57B9YG5Y1E Benzyl alcohol, alpha-(1-aminoethyl)-, (-)- EINECS 211-850-9 FT-0632222 (1R, 2S)-(-)- norephedrine (1R,2S)-(-)-2-Amino-1-phenyl-1-propanol L-(-)-Ephedrine (1R,2S)-Norephedrine Norpseudoephedrine (\|AS)-rel-\|A-[(1R)-1-Aminoethyl]-benzenemethanol Phenylpropanolamina 1S,2R-PHENYLPROPANOLAMINE HYDROCHLORIDE PPA [Nasal Decongestant] AC1L1UWH SR-05000001534 Benzenemethanol, alpha-(1-aminoethyl)-, (R,S)- W-106029 C07911 dl-alpha-(1-Aminoethyl)benzyl alcohol erythro-2-Amino-1-phenyl-1-propanol (+/-)-Norephedrine I01-8924 KBio2_004151 (1R,2S)-(-)-Phenylpropanolamine l-Phenylpropanolamine (R,S)-(+-)-alpha-(1-Aminoethyl)benzenemethanol NSC 9920 1-Propanol, 2-amino-1-phenyl- Phenylpropanolamine (INN) 492-41-1 Spectrum2_000016 API0004782 UNII-27A0HLC3HH component DLNKOYKMWOXYQA-APPZFPTMSA-N Benzenemethanol, alpha-(1-aminoethyl)-, (R-(R,S))- (9CI) ZINC157545 CCG-214826 DLNKOYKMWOXYQA-CBAPKCEASA-N Fenilpropanolamina KBioGR_001385 (1R,2S)-2-amino-1-phenyl-propan-1-ol N0608 (R-(R,S))-alpha-(1-Aminoethyl)benzyl alcohol PDSP1_001349 134-60-1 Phenylpropanolaminum AB01275538-01 Spectrum5_001156 Benzenemethanol, alpha-((1R)-1-aminoethyl)-, (alphaS)-rel- UNII-683H0R9659 component DLNKOYKMWOXYQA-CBAPKCEASA-N Benzyl alcohol,.alpha.-(1-aminoethyl)- CHEMBL136560 EINECS 238-900-2 (+-)-Norephedrine HMS2090P12 (1r, 2s)-(-)-norephedrine (1R,2S)-(-)-Norephedrine L-(-)-Norephedrine (1R,2S)-PHENYLPROPANOLAMINE norpseudoephedrine, (R-(R,S))-isomer 1-(-)-ephedrine Phenylpropanolamina [INN-Spanish] 36393-57-4 SCHEMBL152038 AKOS015891206 SR-05000001534-1 Benzenemethanol, alpha-(1-aminoethyl)-, (R,S)-(+-)- (9CI) WLN: ZY1&YQR -L C16719 dl-alpha-Hydroxy-beta-aminopropylbenzene Fansia (TN) (+/-)-Phenylpropanolamine InChI=1/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9-/m0/s [ Show all ]
Inchi Key	DLNKOYKMWOXYQA-CBAPKCEASA-N
Inchi ID	InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9-/m0/s1
PubChem CID	10297
ChEMBL	CHEMBL136560
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	9600.0 nM	PMID12238918	ChEMBL

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