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| Name | Beta-3 adrenergic receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | ADRB3 |
| Synonym | ADRB Adrb-3 adrenergic receptor atypical beta-adrenoceptor beta 3-AR [ Show all ] |
| Disease | Urinary incontinence Diabetes Glaucoma Hypertension Irritable bowel syndrome [ Show all ] |
| Length | 408 |
| Amino acid sequence | MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS |
| UniProt | P13945 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P13945 |
| 3D structure model | This predicted structure model is from GPCR-EXP P13945. |
| BioLiP | N/A |
| Therapeutic Target Database | T51408 |
| ChEMBL | CHEMBL246 |
| IUPHAR | 30 |
| DrugBank | BE0001012, BE0004872 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 49 |  CHEMBL102611 | C24H29N3O6S | 487.571 | 9 / 4 | 2.3 | Yes |
| 975 |  CHEMBL3298692 | C32H38N4O6 | 574.678 | 8 / 6 | 3.9 | No |
| 1021 |  CHEMBL2205816 | C18H20N2O | 280.371 | 3 / 1 | 1.8 | Yes |
| 1071 |  CHEMBL516056 | C28H44N2O8S | 568.726 | 10 / 6 | N/A | No |
| 1246 |  CHEMBL556022 | C20H30Cl2N4O3S | 477.445 | 7 / 5 | N/A | N/A |
| 1340 |  CHEMBL2261203 | C29H36N4O5S2 | 584.75 | 8 / 4 | 3.9 | No |
| 2152 |  BDBM50097799 | C29H32N4O6S2 | 596.717 | 10 / 6 | 3.3 | No |
| 2280 |  1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
| 2926 |  CHEMBL418308 | C35H32N4O3S2 | 620.786 | 8 / 3 | 6.0 | No |
| 3276 |  CHEMBL475389 | C25H38N2O6S | 494.647 | 8 / 5 | 2.5 | Yes |
| 3506 |  CHEMBL2348219 | C25H35N3O6 | 473.57 | 7 / 5 | 2.3 | Yes |
| 3768 |  CHEMBL105095 | C23H33N3O5S | 463.593 | 7 / 5 | 1.6 | Yes |
| 4280 |  CHEMBL250978 | C27H32N2O7S | 528.62 | 9 / 4 | 2.5 | No |
| 4602 |  CHEMBL208352 | C24H25ClN2O3 | 424.925 | 5 / 3 | 4.4 | Yes |
| 4679 |  CHEMBL457514 | C24H33N3O2 | 395.547 | 5 / 1 | 3.1 | Yes |
| 5076 |  CHEMBL104481 | C29H42N4O4 | 510.679 | 6 / 5 | 4.1 | No |
| 5145 |  CHEMBL466923 | C30H30N4O3 | 494.595 | 5 / 4 | 4.5 | Yes |
| 5188 |  CHEMBL498519 | C25H24ClNO4 | 437.92 | 5 / 3 | 2.5 | Yes |
| 5273 |  CHEMBL279931 | C19H21ClN2O | 328.84 | 2 / 3 | 3.8 | Yes |
| 5276 |  CHEMBL25823 | C19H21ClN2O | 328.84 | 2 / 3 | 3.8 | Yes |
| 5278 |  CHEMBL282039 | C19H21ClN2O | 328.84 | 2 / 3 | 3.8 | Yes |
| 5279 |  CHEMBL25133 | C19H21ClN2O | 328.84 | 2 / 3 | 3.8 | Yes |
| 5281 |  CHEMBL26393 | C19H21ClN2O | 328.84 | 2 / 3 | 3.8 | Yes |
| 5528 |  CHEMBL3128185 | C30H29FN4O2S | 528.646 | 7 / 3 | 4.2 | No |
| 6465 |  CHEMBL443435 | C29H41N3O10S | 623.718 | 12 / 7 | N/A | No |
| 6645 |  CHEMBL429396 | C20H23ClN2O2 | 358.866 | 3 / 3 | 3.8 | Yes |
| 6670 |  CHEMBL1203989 | C24H27ClN4O4S | 503.014 | 6 / 5 | N/A | No |
| 6680 |  CHEMBL302028 | C35H44N2O4 | 556.747 | 6 / 3 | 8.4 | No |
| 463715 |  CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
| 7839 |  CHEMBL1078695 | C30H31N3O2 | 465.597 | 4 / 3 | 4.6 | Yes |
| 8449 |  CHEMBL457696 | C29H34N4O4 | 502.615 | 7 / 1 | 4.7 | No |
| 8492 |  CHEMBL102291 | C14H24N2O4S | 316.416 | 6 / 4 | 0.8 | Yes |
| 8580 |  CHEMBL479530 | C26H35Cl3N4O4S | 606.0 | 7 / 7 | N/A | No |
| 8600 |  CHEMBL34406 | C31H31N5O6S | 601.678 | 11 / 3 | 3.4 | No |
| 9123 |  CHEMBL183611 | C26H31N3O5 | 465.55 | 6 / 5 | 2.7 | Yes |
| 9332 |  CHEMBL24899 | C19H20BrClN2O | 407.736 | 2 / 3 | 4.5 | Yes |
| 9405 |  CHEMBL100351 | C30H34N4O8S2 | 642.742 | 11 / 5 | -0.2 | No |
| 9623 |  CHEMBL1083053 | C30H35N3O4 | 501.627 | 6 / 1 | 4.2 | No |
| 10463 |  BDBM50097795 | C25H27N5O5S | 509.581 | 8 / 4 | 2.0 | No |
| 10593 |  CHEMBL39269 | C30H28N4O4S | 540.638 | 8 / 3 | 3.8 | No |
| 10731 |  CHEMBL3287723 | C25H32O7 | 444.524 | 7 / 2 | 5.7 | No |
| 10892 |  CHEMBL1085837 | C30H41NO7 | 527.658 | 8 / 5 | N/A | No |
| 11075 |  CHEMBL61817 | C19H22N4O4 | 370.409 | 7 / 4 | -1.5 | Yes |
| 11422 |  CHEMBL458961 | C22H30N2O4 | 386.492 | 6 / 3 | 3.0 | Yes |
| 11696 |  Propranolol, L- | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11726 |  propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11771 |  CHEMBL550445 | C25H29N3O3S | 451.585 | 5 / 4 | 3.9 | Yes |
| 11804 |  CHEMBL321957 | C28H36N4O5S | 540.679 | 8 / 4 | 4.0 | No |
| 11818 |  CHEMBL466713 | C23H26N4O3 | 406.486 | 6 / 3 | 1.5 | Yes |
| 11891 |  CHEMBL551350 | C26H30N2O5 | 450.535 | 6 / 4 | 3.2 | Yes |
| 12227 |  CHEMBL516804 | C26H28FNO4 | 437.511 | 6 / 3 | 2.3 | Yes |
| 12976 |  CHEMBL1204006 | C25H30ClN3O2S | 472.044 | 4 / 5 | N/A | N/A |
| 12999 |  CHEMBL67998 | C33H38N4O5S | 602.75 | 7 / 6 | 5.7 | No |
| 13134 |  CHEMBL506518 | C32H50N2O8S | 622.818 | 10 / 5 | N/A | No |
| 13271 |  CHEMBL526472 | C23H22ClNO3S | 427.943 | 5 / 3 | 2.6 | Yes |
| 14075 |  CHEMBL3128199 | C25H27FN4O2S | 466.575 | 7 / 4 | 3.3 | Yes |
| 14147 |  CHEMBL184407 | C24H27N3O6S3 | 549.675 | 9 / 4 | 3.2 | No |
| 14152 |  CHEMBL107382 | C30H36F2N4O4 | 554.639 | 8 / 5 | 4.0 | No |
| 14610 |  CHEMBL469884 | C26H30N2O4 | 434.536 | 6 / 4 | 1.6 | Yes |
| 14731 |  CHEMBL109288 | C19H26ClN3O3S | 411.945 | 6 / 2 | 2.3 | Yes |
| 15364 |  CHEMBL1089734 | C28H27N3O2 | 437.543 | 4 / 3 | 4.0 | Yes |
| 15459 |  CHEMBL2205829 | C19H19NO3 | 309.365 | 4 / 1 | 2.2 | Yes |
| 16053 |  CHEMBL63825 | C31H29F3N6O5S | 654.665 | 13 / 3 | 4.7 | No |
| 553328 |  L-748,337 | C26H31N3O5S | 497.61 | 7 / 4 | 2.0 | Yes |
| 16158 |  SCHEMBL6074126 | C22H26N4O3S | 426.535 | 7 / 3 | 2.1 | Yes |
| 16499 |  YM-08316 | C23H30N2O9 | 478.498 | 10 / 7 | N/A | No |
| 16579 |  CHEMBL1257914 | C26H28N4O3S | 476.595 | 8 / 3 | 4.5 | Yes |
| 16676 |  CHEMBL101132 | C27H33N5O6S | 555.65 | 9 / 5 | 1.9 | No |
| 17165 |  CHEMBL490222 | C30H27ClN2O5 | 531.005 | 6 / 4 | 3.4 | No |
| 17346 |  CHEMBL101606 | C25H31N5O8S2 | 593.67 | 12 / 5 | -1.9 | No |
| 17494 |  CHEMBL559486 | C31H38N2O6S | 566.713 | 7 / 4 | 4.2 | No |
| 17604 |  CHEMBL33155 | C32H31FN6O6S | 646.694 | 12 / 4 | 3.3 | No |
| 18018 |  CHEMBL264819 | C25H28N4O5S2 | 528.642 | 8 / 5 | 2.4 | No |
| 18187 |  CHEMBL286126 | C26H34N4O9S | 578.637 | 12 / 7 | -1.9 | No |
| 18712 |  CHEMBL67416 | C23H28N4O5S | 472.56 | 9 / 4 | 1.9 | Yes |
| 18731 |  CHEMBL270964 | C26H30N2O3 | 418.537 | 5 / 4 | 2.8 | Yes |
| 18884 |  CHEMBL497281 | C26H26ClNO4 | 451.947 | 5 / 3 | 2.6 | Yes |
| 19304 |  CHEMBL453048 | C27H31NO4 | 433.548 | 5 / 3 | 2.8 | Yes |
| 19571 |  CHEMBL3298325 | C33H34N4O4 | 550.659 | 7 / 6 | 3.7 | No |
| 20352 |  CHEMBL3128187 | C23H27N5O2 | 405.502 | 5 / 3 | 1.9 | Yes |
| 20600 |  CHEMBL104180 | C21H23N3O3S | 397.493 | 6 / 3 | 2.1 | Yes |
| 20831 |  CHEMBL1084656 | C26H40N2O9S | 556.671 | 11 / 6 | N/A | No |
| 21351 |  CHEMBL1684585 | C23H26N4O2S | 422.547 | 6 / 4 | 2.7 | Yes |
| 22115 |  CHEMBL368392 | C32H39N5O5S | 605.754 | 8 / 4 | 3.4 | No |
| 22158 |  CHEMBL250352 | C21H25N3O3 | 367.449 | 6 / 2 | 2.5 | Yes |
| 22173 |  suloctidil | C20H35NOS | 337.566 | 3 / 2 | 5.8 | No |
| 22293 |  5-[4-[4-[[(2R)-2-Hydroxy-2-[3-(methylsulfonylamino)phenyl]ethyl]amino]piperidino]benzyl]-2,4-thiazolidinedione | C24H30N4O5S2 | 518.647 | 9 / 4 | 2.1 | No |
| 22392 |  CHEMBL111320 | C22H30ClN3O3S | 452.01 | 6 / 4 | 3.7 | Yes |
| 22426 |  CHEMBL293818 | C29H39N5O4S | 553.722 | 7 / 4 | 3.6 | No |
| 22443 |  CHEMBL284612 | C23H30N4O7S | 506.574 | 10 / 6 | -1.2 | No |
| 22948 |  CHEMBL383511 | C24H25ClN2O3 | 424.925 | 5 / 4 | 2.3 | Yes |
| 23026 |  CHEMBL250579 | C41H42N4O5 | 670.81 | 7 / 4 | 5.7 | No |
| 23070 |  CHEMBL305808 | C19H26N2O6S | 410.485 | 8 / 4 | 1.4 | Yes |
| 23604 |  CHEMBL1258259 | C27H30N4O3S | 490.622 | 8 / 3 | 4.9 | Yes |
| 23652 |  CHEMBL434763 | C29H35N5O5 | 533.629 | 7 / 4 | 2.8 | No |
| 23954 |  CHEMBL323258 | C31H46N4O4 | 538.733 | 6 / 5 | 5.2 | No |
| 24055 |  CHEMBL245873 | C22H23ClN2O3S | 430.947 | 6 / 4 | 2.0 | Yes |
| 24243 |  CHEMBL431048 | C30H37F2N5O8S2 | 697.77 | 13 / 6 | 1.7 | No |
| 24513 |  BDBM50097804 | C26H28N4O5S | 508.593 | 8 / 5 | 2.9 | No |
| 24960 |  CHEMBL127656 | C36H44N8OS | 636.863 | 8 / 4 | 7.9 | No |
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