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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Beta-3 adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRB3
Synonym	ADRB Adrb-3 adrenergic receptor atypical beta-adrenoceptor beta 3-AR Beta-3 adrenoceptor Beta-3 adrenoreceptor beta3-adrenergic receptor beta3-adrenoceptor [ Show all ]
Disease	Urinary incontinence Diabetes Glaucoma Hypertension Irritable bowel syndrome Major depressive disorder; Obesity; Type 2 diabetes Major depressive disorder; Severe mood disorders Obesity Gastrointestinal disease Obesity; Type 2 diabetes Asthma; Chronic obstructive pulmonary disease Asthma Angina pectoris Overactive bladder disorder Type 2 diabetes [ Show all ]
Length	408
Amino acid sequence	MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
UniProt	P13945
Protein Data Bank	N/A
GPCR-HGmod model	P13945
3D structure model	This predicted structure model is from GPCR-EXP P13945.
BioLiP	N/A
Therapeutic Target Database	T51408
ChEMBL	CHEMBL246
IUPHAR	30
DrugBank	BE0001012, BE0004872

Ligand

Name	CHEMBL302028
Molecular formula	C35H44N2O4
IUPAC name	2,6-ditert-butyl-4-[3-[4-[(2-hydroxy-3-isoquinolin-5-yloxypropyl)amino]phenoxy]propyl]phenol
Molecular weight	556.747
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	8.4
Synonyms	2,6-Di-tert-butyl-4-[3-[4-[2-hydroxy-3-(5-isoquinolinyloxy)propylamino]phenoxy]propyl]phenol
Inchi Key	AIZLRGITAPYWOD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C35H44N2O4/c1-34(2,3)30-19-24(20-31(33(30)39)35(4,5)6)9-8-18-40-28-14-12-26(13-15-28)37-22-27(38)23-41-32-11-7-10-25-21-36-17-16-29(25)32/h7,10-17,19-21,27,37-39H,8-9,18,22-23H2,1-6H3
PubChem CID	44307041
ChEMBL	CHEMBL302028
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
cAMP production	76.3 pM min-1 well-1	PMID11755356	ChEMBL
cAMP production	129.6 pM min-1 well-1	PMID11755356	ChEMBL

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