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GLASS

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GPCR

Name	Beta-3 adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRB3
Synonym	ADRB Adrb-3 adrenergic receptor atypical beta-adrenoceptor beta 3-AR Beta-3 adrenoceptor Beta-3 adrenoreceptor beta3-adrenergic receptor beta3-adrenoceptor [ Show all ]
Disease	Urinary incontinence Diabetes Glaucoma Hypertension Irritable bowel syndrome Major depressive disorder; Obesity; Type 2 diabetes Major depressive disorder; Severe mood disorders Obesity Gastrointestinal disease Obesity; Type 2 diabetes Asthma; Chronic obstructive pulmonary disease Asthma Angina pectoris Overactive bladder disorder Type 2 diabetes [ Show all ]
Length	408
Amino acid sequence	MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
UniProt	P13945
Protein Data Bank	N/A
GPCR-HGmod model	P13945
3D structure model	This predicted structure model is from GPCR-EXP P13945.
BioLiP	N/A
Therapeutic Target Database	T51408
ChEMBL	CHEMBL246
IUPHAR	30
DrugBank	BE0001012, BE0004872

Ligand

Name	CHEMBL434763
Molecular formula	C29H35N5O5
IUPAC name	6-[4-[2-[[(2S)-2-hydroxy-3-[(2-oxo-3-propyl-1H-benzimidazol-4-yl)oxy]propyl]amino]-2-methylpropyl]phenoxy]pyridine-3-carboxamide
Molecular weight	533.629
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	2.8
Synonyms	BDBM50193806 (S)-6-(4-(2-(2-hydroxy-3-(2-oxo-3-propyl-2,3-dihydro-1H-benzo[d]imidazol-4-yloxy)propylamino)-2-methylpropyl)phenoxy)nicotinamide
Inchi Key	BHDFOPDSNPFXBU-NRFANRHFSA-N
Inchi ID	InChI=1S/C29H35N5O5/c1-4-14-34-26-23(33-28(34)37)6-5-7-24(26)38-18-21(35)17-32-29(2,3)15-19-8-11-22(12-9-19)39-25-13-10-20(16-31-25)27(30)36/h5-13,16,21,32,35H,4,14-15,17-18H2,1-3H3,(H2,30,36)(H,33,37)/t21-/m0/s1
PubChem CID	44419324
ChEMBL	CHEMBL434763
IUPHAR	N/A
BindingDB	50193806
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5.2 nM	PMID16931005	BindingDB,ChEMBL
Emax	73.9 %	PMID16931005	ChEMBL

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