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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Beta-3 adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRB3
Synonym	ADRB Adrb-3 adrenergic receptor atypical beta-adrenoceptor beta 3-AR Beta-3 adrenoceptor Beta-3 adrenoreceptor beta3-adrenergic receptor beta3-adrenoceptor [ Show all ]
Disease	Urinary incontinence Diabetes Glaucoma Hypertension Irritable bowel syndrome Major depressive disorder; Obesity; Type 2 diabetes Major depressive disorder; Severe mood disorders Obesity Gastrointestinal disease Obesity; Type 2 diabetes Asthma; Chronic obstructive pulmonary disease Asthma Angina pectoris Overactive bladder disorder Type 2 diabetes [ Show all ]
Length	408
Amino acid sequence	MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
UniProt	P13945
Protein Data Bank	N/A
GPCR-HGmod model	P13945
3D structure model	This predicted structure model is from GPCR-EXP P13945.
BioLiP	N/A
Therapeutic Target Database	T51408
ChEMBL	CHEMBL246
IUPHAR	30
DrugBank	BE0001012, BE0004872

Ligand

Name	CHEMBL1085837
Molecular formula	C30H41NO7
IUPAC name	acetic acid;2-(hydroxymethyl)-4-[(1R)-1-hydroxy-2-[6-[2-(naphthalen-1-ylmethoxy)ethoxy]hexylamino]ethyl]phenol
Molecular weight	527.658
Hydrogen bond acceptor	8
Hydrogen bond donor	5
XlogP	None
Synonyms	N/A
Inchi Key	APEHTRASELHRSR-JCOPYZAKSA-N
Inchi ID	InChI=1S/C28H37NO5.C2H4O2/c30-20-25-18-23(12-13-27(25)31)28(32)19-29-14-5-1-2-6-15-33-16-17-34-21-24-10-7-9-22-8-3-4-11-26(22)24;1-2(3)4/h3-4,7-13,18,28-32H,1-2,5-6,14-17,19-21H2;1H3,(H,3,4)/t28-;/m0./s1
PubChem CID	46832231
ChEMBL	CHEMBL1085837
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5.012 nM	PMID20462258	ChEMBL

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