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GPCR

Name	Beta-3 adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRB3
Synonym	ADRB Adrb-3 adrenergic receptor atypical beta-adrenoceptor beta 3-AR Beta-3 adrenoceptor Beta-3 adrenoreceptor beta3-adrenergic receptor beta3-adrenoceptor [ Show all ]
Disease	Urinary incontinence Diabetes Glaucoma Hypertension Irritable bowel syndrome Major depressive disorder; Obesity; Type 2 diabetes Major depressive disorder; Severe mood disorders Obesity Gastrointestinal disease Obesity; Type 2 diabetes Asthma; Chronic obstructive pulmonary disease Asthma Angina pectoris Overactive bladder disorder Type 2 diabetes [ Show all ]
Length	408
Amino acid sequence	MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
UniProt	P13945
Protein Data Bank	N/A
GPCR-HGmod model	P13945
3D structure model	This predicted structure model is from GPCR-EXP P13945.
BioLiP	N/A
Therapeutic Target Database	T51408
ChEMBL	CHEMBL246
IUPHAR	30
DrugBank	BE0001012, BE0004872

Ligand

Name	BDBM50097804
Molecular formula	C26H28N4O5S
IUPAC name	4-hydroxy-5-[[4-[4-[[(2R)-2-hydroxy-2-[(2-oxo-1H-quinolin-5-yl)oxy]ethyl]amino]piperidin-1-yl]phenyl]methyl]-3H-1,3-thiazol-2-one
Molecular weight	508.593
Hydrogen bond acceptor	8
Hydrogen bond donor	5
XlogP	2.9
Synonyms	5-(4-{4-[2-Hydroxy-2-(2-oxo-1,2-dihydro-quinolin-5-yloxy)-ethylamino]-piperidin-1-yl}-benzyl)-thiazolidine-2,4-dione
Inchi Key	BIKQQCJDQLEKDX-XMMPIXPASA-N
Inchi ID	InChI=1S/C26H28N4O5S/c31-23-9-8-19-20(28-23)2-1-3-21(19)35-24(32)15-27-17-10-12-30(13-11-17)18-6-4-16(5-7-18)14-22-25(33)29-26(34)36-22/h1-9,17,24,27,32-33H,10-15H2,(H,28,31)(H,29,34)/t24-/m1/s1
PubChem CID	91931607
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50097804
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	13.0 nM	PMID11277513	BindingDB

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