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GPCR

Name	Beta-3 adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRB3
Synonym	ADRB Adrb-3 adrenergic receptor atypical beta-adrenoceptor beta 3-AR Beta-3 adrenoceptor Beta-3 adrenoreceptor beta3-adrenergic receptor beta3-adrenoceptor [ Show all ]
Disease	Urinary incontinence Diabetes Glaucoma Hypertension Irritable bowel syndrome Major depressive disorder; Obesity; Type 2 diabetes Major depressive disorder; Severe mood disorders Obesity Gastrointestinal disease Obesity; Type 2 diabetes Asthma; Chronic obstructive pulmonary disease Asthma Angina pectoris Overactive bladder disorder Type 2 diabetes [ Show all ]
Length	408
Amino acid sequence	MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
UniProt	P13945
Protein Data Bank	N/A
GPCR-HGmod model	P13945
3D structure model	This predicted structure model is from GPCR-EXP P13945.
BioLiP	N/A
Therapeutic Target Database	T51408
ChEMBL	CHEMBL246
IUPHAR	30
DrugBank	BE0001012, BE0004872

Ligand

Name	CHEMBL250579
Molecular formula	C41H42N4O5
IUPAC name	6-[4-[2-[[(2S)-3-[(3,3-dibenzyl-2-oxo-1H-indol-4-yl)oxy]-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]pyridine-3-carboxamide
Molecular weight	670.81
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	5.7
Synonyms	BDBM50224027 (S)-6-(4-(2-(3-(3,3-dibenzyl-2-oxoindolin-4-yloxy)-2-hydroxypropylamino)-2-methylpropyl)phenoxy)nicotinamide
Inchi Key	BGHYFJPSEDCVLZ-YTTGMZPUSA-N
Inchi ID	InChI=1S/C41H42N4O5/c1-40(2,22-30-16-19-33(20-17-30)50-36-21-18-31(25-43-36)38(42)47)44-26-32(46)27-49-35-15-9-14-34-37(35)41(39(48)45-34,23-28-10-5-3-6-11-28)24-29-12-7-4-8-13-29/h3-21,25,32,44,46H,22-24,26-27H2,1-2H3,(H2,42,47)(H,45,48)/t32-/m0/s1
PubChem CID	44444172
ChEMBL	CHEMBL250579
IUPHAR	N/A
BindingDB	50224027
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	268.0 nM	PMID17911024	BindingDB
EC50	268.1 nM	PMID17911024	ChEMBL
Emax	48.5 %	PMID17911024	ChEMBL

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