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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Beta-3 adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRB3
Synonym	ADRB Adrb-3 adrenergic receptor atypical beta-adrenoceptor beta 3-AR Beta-3 adrenoceptor Beta-3 adrenoreceptor beta3-adrenergic receptor beta3-adrenoceptor [ Show all ]
Disease	Urinary incontinence Diabetes Glaucoma Hypertension Irritable bowel syndrome Major depressive disorder; Obesity; Type 2 diabetes Major depressive disorder; Severe mood disorders Obesity Gastrointestinal disease Obesity; Type 2 diabetes Asthma; Chronic obstructive pulmonary disease Asthma Angina pectoris Overactive bladder disorder Type 2 diabetes [ Show all ]
Length	408
Amino acid sequence	MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
UniProt	P13945
Protein Data Bank	N/A
GPCR-HGmod model	P13945
3D structure model	This predicted structure model is from GPCR-EXP P13945.
BioLiP	N/A
Therapeutic Target Database	T51408
ChEMBL	CHEMBL246
IUPHAR	30
DrugBank	BE0001012, BE0004872

Ligand

Name	CHEMBL33155
Molecular formula	C32H31FN6O6S
IUPAC name	methyl N-[(4-fluorophenyl)-[3-[4-[[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]sulfamoyl]phenyl]-1,2,4-oxadiazol-5-yl]methyl]carbamate
Molecular weight	646.694
Hydrogen bond acceptor	12
Hydrogen bond donor	4
XlogP	3.3
Synonyms	{(4-Fluoro-phenyl)-[3-(4-{4-[2-((R)-2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenylsulfamoyl}-phenyl)-[1,2,4]oxadiazol-5-yl]-methyl}-carbamic acid methyl ester BDBM50089493 N-[4-[2-[[(R)-2-(3-Pyridinyl)-2-hydroxyethyl]amino]ethyl]phenyl]-4-[5-[alpha-(methoxycarbonylamino)-4-fluorobenzyl]-1,2,4-oxadiazole-3-yl]benzenesulfonamide
Inchi Key	AYNAFGSPQRKZFM-XLTVJXRZSA-N
Inchi ID	InChI=1S/C32H31FN6O6S/c1-44-32(41)36-29(22-6-10-25(33)11-7-22)31-37-30(38-45-31)23-8-14-27(15-9-23)46(42,43)39-26-12-4-21(5-13-26)16-18-35-20-28(40)24-3-2-17-34-19-24/h2-15,17,19,28-29,35,39-40H,16,18,20H2,1H3,(H,36,41)/t28-,29?/m0/s1
PubChem CID	44281408
ChEMBL	CHEMBL33155
IUPHAR	N/A
BindingDB	50089493
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Activation	80.0 %	PMID10888325	ChEMBL
EC50	10.0 nM	PMID10888325	BindingDB,ChEMBL

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