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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	MLS000391056
Molecular formula	C20H27ClN2OS
IUPAC name	1-[1-(2-chlorophenyl)-2-oxocyclohexyl]-3-cyclohexyl-1-methylthiourea
Molecular weight	378.959
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.7
Synonyms	1-[1-(2-chlorophenyl)-2-oxocyclohexyl]-3-cyclohexyl-1-methylthiourea cid_4006073 AC1N1J2G SMR000260093 1-[1-(2-chlorophenyl)-2-keto-cyclohexyl]-3-cyclohexyl-1-methyl-thiourea HMS2601O20 AKOS034376070 MolPort-005-726-509 CHEMBL1427917 Z45754981 1-[1-(2-chlorophenyl)-2-oxidanylidene-cyclohexyl]-3-cyclohexyl-1-methyl-thiourea 473667-85-5 MCULE-3402174536 BDBM42064 Oprea1_594811 [ Show all ]
Inchi Key	CBXZCXFSSRYOGA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H27ClN2OS/c1-23(19(25)22-15-9-3-2-4-10-15)20(14-8-7-13-18(20)24)16-11-5-6-12-17(16)21/h5-6,11-12,15H,2-4,7-10,13-14H2,1H3,(H,22,25)
PubChem CID	4006073
ChEMBL	CHEMBL1427917
IUPHAR	N/A
BindingDB	42064
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<42000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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