Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Histamine H1 receptor
Species	Mus musculus (Mouse)
Gene	Hrh1
Synonym	H1 receptor H1R HH1R Hisr
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSLPNTSSASEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFLSFLWVIPILGWHHFTPLAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPTFLEIKLRSEDAKEGAKKPGKESPWGVQKRPSRDPTGGLDQKSTSEDPKVTSPTVFSQEGERETVTRPCFRLDVMQTQPVPEGDARGSKANDQTLSQPKMDEQSLSTCRRISETSEDQTLVDRQSFSRTTDSDTSIEPGLGKVKARSRSNSGLDYIKVTWKRLRSHSRQYVSGLHLNRERKAAKQLGCIMAAFILCWIPYFIFFMVIAFCNSCCSEPVHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
UniProt	P70174
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4322
IUPHAR	N/A
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
3360	CHEMBL358348	C22H23NO3	349.43	4 / 1	1.2	Yes
31952	CHEMBL356592	C21H22N2O3	350.418	5 / 1	-0.5	Yes
57374	CHEMBL385133	C25H29FN2O4	440.515	6 / 1	1.4	Yes
81062	CHEMBL221678	C25H29FN2O4	440.515	6 / 1	1.2	Yes
87212	CHEMBL223881	C25H30N2O3	406.526	4 / 1	1.5	Yes
106719	CHEMBL146215	C20H21NO	291.394	2 / 0	3.9	Yes
108232	CHEMBL146253	C22H23FN2O3	382.435	6 / 1	0.2	Yes
117985	CHEMBL358124	C19H20N2O	292.382	3 / 0	2.3	Yes
124520	JNJ-7777120	C14H16ClN3O	277.752	2 / 1	2.3	Yes
147290	loratadine	C22H23ClN2O2	382.888	3 / 0	5.2	No
168436	CHEMBL358497	C19H20N2O	292.382	3 / 0	2.3	Yes
175871	CHEMBL221730	C27H26ClFN2O3S	513.024	6 / 1	3.7	No
225679	CHEMBL426786	C26H32N2O3	420.553	4 / 1	2.7	Yes
262396	CHEMBL222356	C27H27FN2O4	462.521	6 / 1	2.1	Yes
264448	CHEMBL222139	C27H27FN2O3S	478.582	6 / 1	2.7	Yes
270297	ACRIVASTINE	C22H24N2O2	348.446	4 / 1	1.6	Yes
285865	CHEMBL183706	C26H32N2O4	436.552	5 / 1	1.6	Yes
291130	CHEMBL52124	C21H26ClNO2	359.894	3 / 0	N/A	N/A
332468	CHEMBL1935574	C16H17N5O	295.346	6 / 2	1.7	Yes
351243	CHEMBL375208	C26H30N2O3	418.537	4 / 1	2.2	Yes
359603	161522-25-4	C21H21FN2O3	368.408	6 / 1	-0.4	Yes
381958	CHEMBL374059	C25H29FN2O3	424.516	5 / 1	1.6	Yes
399743	CHEMBL147057	C21H22N2O3	350.418	5 / 1	-0.5	Yes
401179	CHEMBL374675	C27H27FN2O4	462.521	6 / 1	2.3	Yes
414872	CHEMBL223025	C25H30N2O4	422.525	5 / 1	1.1	Yes
425352	ketotifen	C19H19NOS	309.427	3 / 0	3.2	Yes
426102	CHEMBL221716	C27H34N2O5	466.578	6 / 1	1.6	Yes
426536	CHEMBL376202	C27H28N2O3S	460.592	5 / 1	2.6	Yes
430698	cetirizine	C21H25ClN2O3	388.892	5 / 1	1.7	Yes
432240	CHEMBL221664	C26H31FN2O3	438.543	5 / 1	2.8	Yes
436637	CHEMBL359378	C21H21FN2O3	368.408	6 / 1	-0.4	Yes
437441	CHEMBL374869	C27H32N2O5	464.562	6 / 1	1.4	Yes

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417