Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Beta-1 adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adrb1
Synonym	adrenergic receptor beta1-adrenoceptor Beta-1 adrenoreceptor Beta-1 adrenoceptor beta-1 adrenergic receptor ADRB1R beta 1-AR B1AR Adrenergic receptor beta 1 Adrb-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
UniProt	P18090
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3252
IUPHAR	N/A
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
129	CHEMBL149540	C16H24N4O2	304.394	5 / 2	1.6	Yes
1262	CHEMBL479644	C20H24ClNO4	377.865	5 / 3	N/A	N/A
2145	CHEMBL544661	C21H35NO4S	397.574	5 / 2	3.8	Yes
3126	AC1N0YGA	C3H7NO4S	153.152	5 / 2	-4.7	Yes
5140	CHEMBL1682217	C27H26Cl2N4O4	541.429	5 / 6	3.4	No
6723	CHEMBL358360	C18H27N3O3	333.432	5 / 2	1.7	Yes
7239	CHEMBL1178704	C10H22N2O2	202.298	4 / 2	0.7	Yes
10166	CID 44285269	C13H24N2O6	304.343	8 / 4	N/A	N/A
10581	CHEMBL2283384	C27H27BrN4O2	519.443	5 / 1	4.6	No
11720	propranolol	C16H21NO2	259.349	3 / 2	3.0	Yes
12510	CHEMBL544661	C21H36ClNO4S	434.032	5 / 3	N/A	N/A
13029	CHEMBL143944	C21H24FN3O3S	417.499	7 / 2	2.5	Yes
13066	CHEMBL3230442	C27H38N2O9	534.606	10 / 5	N/A	No
14579	CHEMBL2375978	C17H25NO5	323.389	6 / 2	1.2	Yes
15866	CHEMBL146767	C17H24ClN3O3	353.847	5 / 2	2.2	Yes
16559	CHEMBL2375990	C16H23NO5	309.362	6 / 2	0.8	Yes
19634	CHEMBL287651	C17H23NO2	273.376	3 / 2	3.5	Yes
20171	imipramine	C19H24N2	280.415	2 / 0	4.8	Yes
21602	CHEMBL543964	C16H16ClN3O	301.774	1 / 3	N/A	N/A
23769	Arotinolol	C15H21N3O2S3	371.532	7 / 3	2.3	Yes
24668	CID 44285288	C12H22N2O6	290.316	8 / 4	N/A	N/A
26185	CHEMBL2375985	C17H25NO5	323.389	6 / 2	1.2	Yes
26701	timolol	C13H24N4O3S	316.42	8 / 2	1.8	Yes
27787	CHEMBL2375993	C18H27NO5	337.416	6 / 2	1.7	Yes
28861	CHEMBL314459	C16H23NO3	277.364	4 / 3	2.4	Yes
35855	CID 44285228	C13H24N2O6	304.343	8 / 4	N/A	N/A
36960	CHEMBL42117	C20H30N2O2	330.472	4 / 2	4.2	Yes
39788	CID 44285227	C13H24N2O6	304.343	8 / 4	N/A	N/A
40032	oxprenolol	C15H23NO3	265.353	4 / 2	2.1	Yes
40792	CHEMBL322842	C13H19NO3	237.299	4 / 3	1.3	Yes
41416	CHEMBL6749	C26H36FNO3	429.576	5 / 2	5.4	No
41889	AC1LCWB4	C18H30ClNO3	343.892	5 / 3	N/A	N/A
43230	CHEMBL143733	C20H23N3O5S	417.48	7 / 2	1.1	Yes
45548	CHEMBL1682212	C28H30N4O4	486.572	5 / 6	2.6	No
45798	CHEMBL129190	C8H10FNO3	187.17	5 / 4	-0.5	Yes
46536	CHEMBL32470	C26H30N2O4	434.536	6 / 4	1.6	Yes
47016	CHEMBL520600	C20H23Cl2NO5	428.306	6 / 4	N/A	N/A
51286	CHEMBL41696	C34H56N2O6	588.83	8 / 4	6.6	No
53365	Flusoxolol	C22H30FNO4	391.483	6 / 2	3.7	Yes
53366	AC1OCD6K	C22H30FNO4	391.483	6 / 2	3.7	Yes
53368	CHEMBL43405	C22H30FNO4	391.483	6 / 2	3.7	Yes
559092	BDBM206775	C15H25NO3	267.369	4 / 4	2.7	Yes
559094	BDBM206777	C15H25NO3	267.369	4 / 4	2.7	Yes
537423	CHEMBL3930835	C15H25NO3	267.369	4 / 4	2.7	Yes
537426	SCHEMBL2488461	C15H25NO3	267.369	4 / 4	2.7	Yes
59743	CHEMBL2375995	C16H23NO5	309.362	6 / 1	0.9	Yes
61595	CHEMBL3230447	C23H27NO8	445.468	9 / 5	N/A	N/A
62064	CHEMBL42216	C9H12FNO3	201.197	5 / 4	0.0	Yes
62066	CHEMBL42359	C9H12FNO3	201.197	5 / 4	0.0	Yes
62068	CHEMBL40986	C9H12FNO3	201.197	5 / 4	0.0	Yes
63923	CHEMBL543484	C20H33ClN2O4	400.944	5 / 4	N/A	N/A
66146	CHEMBL229400	C17H22N2O3	302.374	5 / 5	1.6	Yes
66148	CHEMBL229391	C17H22N2O3	302.374	5 / 5	1.6	Yes
66150	CHEMBL229442	C17H22N2O3	302.374	5 / 5	1.6	Yes
66151	CHEMBL229443	C17H22N2O3	302.374	5 / 5	1.6	Yes
68400	CHEMBL7185	C10H13NO3	195.218	4 / 4	0.1	Yes
68705	CHEMBL164145	C30H46N4O6	558.72	8 / 6	2.0	No
69361	practolol	C14H22N2O3	266.341	4 / 3	0.8	Yes
73161	CHEMBL1258452	C18H28N2O3	320.433	5 / 1	3.1	Yes
75793	CHEMBL444003	C20H30N4O3	374.485	6 / 2	2.6	Yes
76053	CHEMBL3230436	C14H21NO6	299.323	7 / 4	N/A	N/A
76929	methionine zwitterion	C5H11NO2S	149.208	3 / 1	-1.2	Yes
77002	DL-Homocysteine	C4H9NO2S	135.181	4 / 3	-3.4	Yes
77132	CHEMBL36211	C23H33NO4	387.52	5 / 2	3.8	Yes
80685	CHEMBL41360	C22H31NO4	373.493	5 / 2	3.6	Yes
82821	CHEMBL1682211	C27H28N4O4	472.545	5 / 6	2.2	No
83598	6-fluoronorepinehprine	C8H10FNO3	187.17	5 / 4	-0.5	Yes
83601	CHEMBL287587	C8H10FNO3	187.17	5 / 4	-0.5	Yes
83607	CHEMBL40796	C8H10FNO3	187.17	5 / 4	-0.5	Yes
83965	CHEMBL349175	C32H52N6O6	616.804	10 / 8	1.3	No
85681	CHEMBL2375986	C18H27NO5	337.416	6 / 2	1.7	Yes
87869	CL-316243	C20H18ClNNa2O7	465.794	8 / 2	N/A	N/A
91383	CID 44285235	C12H22N2O6	290.316	8 / 4	N/A	N/A
91410	CHEMBL2375988	C16H23NO5	309.362	6 / 1	0.9	Yes
91628	CHEMBL2375994	C18H27NO5	337.416	6 / 2	1.4	Yes
94770	CHEMBL542777	C19H31NO5S	385.519	6 / 2	1.7	Yes
94805	CHEMBL543484	C20H32N2O4	364.486	5 / 3	1.9	Yes
95568	CHEMBL389629	C17H21NO3	287.359	4 / 4	2.3	Yes
95569	CHEMBL229388	C17H21NO3	287.359	4 / 4	2.3	Yes
95572	CHEMBL387825	C17H21NO3	287.359	4 / 4	2.3	Yes
95574	CHEMBL229390	C17H21NO3	287.359	4 / 4	2.3	Yes
96383	CHEMBL2261429	C22H27N3O4	397.475	6 / 1	1.3	Yes
96654	CHEMBL41607	C32H52N2O9	608.773	11 / 4	2.6	No
98503	BRN 2116323	C13H20N2O3	252.314	4 / 3	0.6	Yes
98627	CHEMBL2375998	C17H25NO5	323.389	6 / 2	1.3	Yes
98727	CGP 20712A	C23H25F3N4O5	494.471	10 / 4	2.3	Yes
99466	CHEMBL3247308	C16H25NO3	279.38	4 / 2	2.7	Yes
99468	CHEMBL3247309	C16H25NO3	279.38	4 / 2	2.7	Yes
99701	CHEMBL32670	C19H23ClN2O4	378.853	6 / 5	0.6	Yes
100102	CHEMBL552898	C18H30ClNO3	343.892	4 / 3	N/A	N/A
100424	CHEMBL142948	C22H27N3O4S	429.535	7 / 2	2.4	Yes
100676	CHEMBL287886	C22H31NO3	357.494	4 / 2	3.8	Yes
101137	acebutolol	C18H28N2O4	336.432	5 / 3	1.7	Yes
102493	CHEMBL543717	C20H30N2O3	346.471	5 / 2	2.7	Yes
102907	CHEMBL516641	C35H52O4	536.797	4 / 0	10.0	No
107343	CHEMBL266619	C13H21NO4	255.314	5 / 4	1.1	Yes
108334	4-(2-Morpholinyl)pyrocatechol	C10H13NO3	195.218	4 / 3	0.6	Yes
108874	CHEMBL340189	C9H11F2NO2	203.189	5 / 3	0.5	Yes
113532	CHEMBL164146	C32H50N4O6	586.774	8 / 6	3.1	No
114197	CHEMBL142496	C22H24FN3O4S	445.509	7 / 2	1.8	Yes

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417