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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	2-oxoglutarate receptor 1
Species	Homo sapiens (Human)
Gene	OXGR1
Synonym	Alpha-ketoglutarate receptor 1 P2Y15 P2Y-like nucleotide receptor P2Y-like GPCR P2Y purinoceptor 15 P2RY15 oxoglutarate receptor GPR99 G-protein coupled receptor 99 G-protein coupled receptor 80 G protein-coupled receptor 99 G protein-coupled receptor 80 2-oxoglutarate receptor 1 GPR80 [ Show all ]
Disease	N/A
Length	337
Amino acid sequence	MNEPLDYLANASDFPDYAAAFGNCTDENIPLKMHYLPVIYGIIFLVGFPGNAVVISTYIFKMRPWKSSTIIMLNLACTDLLYLTSLPFLIHYYASGENWIFGDFMCKFIRFSFHFNLYSSILFLTCFSIFRYCVIIHPMSCFSIHKTRCAVVACAVVWIISLVAVIPMTFLITSTNRTNRSACLDLTSSDELNTIKWYNLILTATTFCLPLVIVTLCYTTIIHTLTHGLQTDSCLKQKARRLTILLLLAFYVCFLPFHILRVIRIESRLLSISCSIENQIHEAYIVSRPLAALNTFGNLLLYVVVSDNFQQAVCSTVRCKVSGNLEQAKKISYSNNP
UniProt	Q96P68
Protein Data Bank	N/A
GPCR-HGmod model	Q96P68
3D structure model	This predicted structure model is from GPCR-EXP Q96P68.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2150840
IUPHAR	162
DrugBank	N/A

Ligand

Name	CHEMBL2153581
Molecular formula	C23H18F4N4O2
IUPAC name	N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide
Molecular weight	458.417
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	4.0
Synonyms	GTPL5514 BDBM50393143 compound 5g [PMID: 21571530] N-[[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide D02FGK
Inchi Key	SWKGPCNQBPGWNX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H18F4N4O2/c24-19-9-7-15(11-18(19)23(25,26)27)20-12-17(33-31-20)13-29-21(32)5-1-4-16-8-6-14-3-2-10-28-22(14)30-16/h2-3,6-12H,1,4-5,13H2,(H,29,32)
PubChem CID	53358901
ChEMBL	CHEMBL2153581
IUPHAR	5514
BindingDB	50393143
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<30000.0 nM	PMID21571530	BindingDB,ChEMBL

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