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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	Amthamine
Molecular formula	C6H11N3S
IUPAC name	5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine
Molecular weight	157.235
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.4
Synonyms	BRD-K39670393-303-01-3 GTPL4025 SCHEMBL400272 5-Thiazoleethanamine, 2-amino-4-methyl- CHEMBL293762 L000107 2-Amino-5-(2-aminoethyl)-4-methylthiazole DTXSID80162039 RL01758 5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine CHEBI:92694 J-007652 Tocris-0668 142437-67-0 AC1L2QR3 CTK8E9579 NCGC00024719-01 BDBM22881 FT-0694778 RT-011284 5-(2-aminoethyl)-4-methylthiazol-2-amine KB-47389 ZINC5099 2-AMINO-4-METHYLTHIAZOLE-5-ETHANAMINE AKOS006271424 D0I5CT NCGC00024719-02 [ Show all ]
Inchi Key	LHVRFUVVRXGZPV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H11N3S/c1-4-5(2-3-7)10-6(8)9-4/h2-3,7H2,1H3,(H2,8,9)
PubChem CID	126688
ChEMBL	CHEMBL293762
IUPHAR	4025
BindingDB	22881
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Intrinsic activity	0.0 -	PMID21044842	ChEMBL
Ki	5011.87 nM	PMID21044842	ChEMBL
Ki	5012.0 nM	PMID15947036	BindingDB

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