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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	brefeldin A
Molecular formula	C16H24O4
IUPAC name	(3E,11E)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one
Molecular weight	280.364
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.0
Synonyms	(2E,10E)-7-methyl-12,15-bis(oxidanyl)-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one BCP22305 Cyanein SCHEMBL4967933 STK177306 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-, [1R-(1R,2E,6S,10E,11aS,13S,14aR)]- CCG-22194 MLS000534571 (2E,10E)-1,13-dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one AC1NSGNA cid_5362868 NSC 56310 1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one BDBM114316 Decumbin SMR000142008 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-, [1S-(1R,2E,6R,10E,11aR,13R,14aS)]- MLS006011747 (2E,10E)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one AKOS005410728 Cyanaein REGID_for_CID_5362868 SMR004703469 20350-15-6 KQNZDYYTLMIZCT-GFGVWQOPSA-N 4H-Cyclopent[f]oxacyclotridecin-4-one, 1,6,7,8,9,11a.beta.,12,13,14,14a.alpha.-decahydro-1.beta.,13.alpha.-dihydroxy-6.beta.-methyl- CHEMBL1987060 MolPort-002-227-778 [ Show all ]
Inchi Key	KQNZDYYTLMIZCT-GFGVWQOPSA-N
Inchi ID	InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+
PubChem CID	5362868
ChEMBL	CHEMBL1987060
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<42000.0 nM	PubChem BioAssay data set	ChEMBL

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