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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Tacrine
Molecular formula	C13H14N2
IUPAC name	1,2,3,4-tetrahydroacridin-9-amine
Molecular weight	198.269
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.7
Synonyms	TC-134953 Tox21_110073_1 Tacrina [INN-Spanish] NCGC00015054-01 9-amino-1,2,3,4-tetrahydroacridine (THA) NCGC00015054-09 AB00053524_19 NCIOpen2_003667 AKOS000277493 Prestwick2_000329 BPBio1_000371 SPBio_001823 C01453 ST083243 Cognex DSSTox_CID_17272 1,2,3,4-tetrahydro-acridin-9-yl-amine GTPL6687 2aow KBio3_002518 5-Amino-6,7,8,9-tetrahydroacridine (European) Tetrahydroaminoacridine UNII-4VX7YNB537 NCGC00015054-04 9-THA NCGC00024908-01 AC1Q51C5 Oprea1_008681 BBL001044 Romotal BRD-K81473089-003-15-4 Spectrum3_001709 CCG-204132 Tacrin D08555 1,2,3,4-tetra -hydro-9-acridinamine DTXSID1037272 1,2,3,4-tetrahydroacridin-9-amine dihydrochloride KB-216200 4CH-007616 Lopac-A-3773 9-Acridinamine, 1,2,3,4-tetrahydro- Tacrinum Tocris-0965 Z56790573 9-Acridinamine,1,2,3,4-tetrahydro- NCGC00015054-07 AB00053524-17 NCGC00024908-05 Acridine, 9-aminotetrahydro- Prestwick0_000329 BDBM8961 SBI-0050025.P003 BSPBio_003298 Spectrum_000416 CHEMBL95 DB00382 1,2,3,4-Tetrahydro-9-acridineamine FT-0083001 1acj KBio2_003464 5,6,7,8-tetrahydroacridine-9-ylamine MCULE-3628803328 Tenakrin Tox21_302277 Tacrinal NCGC00015054-02 9-Amino-1,2,3,4-Tetrahydroacridine Hydrate Hydrochloride Hydrate NCGC00015054-10 AB0126098 NE25597 ANW-46208 Prestwick3_000329 BRD-K81473089-003-03-0 SPBio_002258 C13H14N2 ST24026722 Cognex (TN) DSSTox_GSID_37272 1,2,3,4-Tetrahydro-acridin-9-ylamine HMS2089F19 2aox KBioGR_001337 Tetrahydroaminocrin VZ20338 Tacrine (INN) 9-Acridinamine, 1,2,3,4-tetrahydro- (9CI) NCGC00015054-05 A18628 NCGC00024908-03 Acridine, 1,2,3,4-tetrahydro-9-amino- PDSP1_000330 BCP03564 Romotal (Salt/Mix) BRN 0147610 Spectrum4_000819 CHEBI:45980 Tacrina D0E6YQ 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE EINECS 206-291-2 1,2,3,4-Tetrahydroaminoacridine KBio1_000936 4VX7YNB537 Lopac0_000036 Tacrinum [INN-Latin] Tox21_110073 ZINC19014866 9-amino-1,2,3,4-tetrahydroacridine NCGC00015054-08 AB00053524_18 NCGC00255540-01 AE-641/00604043 Prestwick1_000329 BIDD:GT0090 SCHEMBL2828 C-110 SR-01000075593-13 cid_1935 DivK1c_000936 1,2,3,4-Tetrahydro-9-aminoacridine FT-0631953 1mx1 KBio2_006032 5-Amino-6,7,8,9-tetrahydroacridine MolPort-000-881-472 Tetrahydroaminacrine Tracine Tacrinal (TN) NCGC00015054-03 9-AMINOTETRAHYDROACRIDINE NCGC00015054-12 AC1L1CK0 NINDS_000936 BAS 00232275 R9947 BRD-K81473089-003-04-8 Spectrum2_001812 CAS-321-64-2 STK101308 CS 12602 DSSTox_RID_79318 1,2,3,4-tetrahydroacridin-9-amine IDI1_000936 321-64-2 KBioSS_000896 Tetrahydroaminocrine YLJREFDVOIBQDA-UHFFFAOYSA-N Tacrine [INN:BAN] 9-Acridinamine, 1,2,3,4-tetrahydro-(9CI) NCGC00015054-06 AB00053524 NCGC00024908-04 Acridine, 9-amino-1,2,3,4-tetrahydro- PDSP2_000328 BCP9000019 SBB003560 BSPBio_000337 Spectrum5_001402 DB-000650 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8) EU-0010966 1684-40-8 (hydrochloride) KBio2_000896 5,6,7,8-tetrahydroacridin-9-amine LS-1191 [ Show all ]
Inchi Key	YLJREFDVOIBQDA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
PubChem CID	1935
ChEMBL	CHEMBL95
IUPHAR	6687
BindingDB	8961
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
412998	5-hydroxytryptamine receptor 2A	P35363	Htr2a	Mus musculus (Mouse)	471
458083	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
413001	Cannabinoid receptor 1	P21554	CNR1	Homo sapiens (Human)	472
413004	Cannabinoid receptor 2	P34972	CNR2	Homo sapiens (Human)	360
412994	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400
412996	Muscarinic acetylcholine receptor M1	P11229	CHRM1	Homo sapiens (Human)	460
412997	Muscarinic acetylcholine receptor M1	P12657	Chrm1	Mus musculus (Mouse)	460
412999	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
413002	Muscarinic acetylcholine receptor M2	Q9ERZ4	Chrm2	Mus musculus (Mouse)	466
413003	Muscarinic acetylcholine receptor M2	P06199	CHRM2	Sus scrofa (Pig)	466
413005	Muscarinic acetylcholine receptor M2	P10980	Chrm2	Rattus norvegicus (Rat)	466
413006	Muscarinic acetylcholine receptor M2	P08172	CHRM2	Homo sapiens (Human)	466
413000	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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