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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Mus musculus (Mouse)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGGTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDDNSRQTCIKIVTKTQKGDACTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	Q9ERZ4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3197
IUPHAR	14
DrugBank	N/A

Ligand

Name	Tacrine
Molecular formula	C13H14N2
IUPAC name	1,2,3,4-tetrahydroacridin-9-amine
Molecular weight	198.269
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.7
Synonyms	Prestwick3_000329 BRD-K81473089-003-03-0 SPBio_002258 C13H14N2 ST24026722 Cognex (TN) DSSTox_GSID_37272 1,2,3,4-Tetrahydro-acridin-9-ylamine HMS2089F19 2aox KBioGR_001337 NCGC00015054-02 9-Amino-1,2,3,4-Tetrahydroacridine Hydrate Hydrochloride Hydrate NCGC00015054-10 AB0126098 NE25597 ANW-46208 Tacrinal (TN) Tetrahydroaminacrine Tracine Romotal (Salt/Mix) BRN 0147610 Spectrum4_000819 CHEBI:45980 Tacrina D0E6YQ 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE EINECS 206-291-2 1,2,3,4-Tetrahydroaminoacridine KBio1_000936 4VX7YNB537 Lopac0_000036 9-Acridinamine, 1,2,3,4-tetrahydro- (9CI) NCGC00015054-05 A18628 NCGC00024908-03 Acridine, 1,2,3,4-tetrahydro-9-amino- PDSP1_000330 BCP03564 Tacrine [INN:BAN] Tetrahydroaminocrine YLJREFDVOIBQDA-UHFFFAOYSA-N BIDD:GT0090 SCHEMBL2828 C-110 SR-01000075593-13 cid_1935 DivK1c_000936 1,2,3,4-Tetrahydro-9-aminoacridine FT-0631953 1mx1 KBio2_006032 5-Amino-6,7,8,9-tetrahydroacridine MolPort-000-881-472 9-amino-1,2,3,4-tetrahydroacridine NCGC00015054-08 AB00053524_18 NCGC00255540-01 AE-641/00604043 Prestwick1_000329 TC-134953 Tox21_110073_1 Tacrina [INN-Spanish] R9947 BRD-K81473089-003-04-8 Spectrum2_001812 CAS-321-64-2 STK101308 CS 12602 DSSTox_RID_79318 1,2,3,4-tetrahydroacridin-9-amine IDI1_000936 321-64-2 KBioSS_000896 NCGC00015054-03 9-AMINOTETRAHYDROACRIDINE NCGC00015054-12 AC1L1CK0 NINDS_000936 BAS 00232275 Tetrahydroaminoacridine UNII-4VX7YNB537 BCP9000019 SBB003560 BSPBio_000337 Spectrum5_001402 DB-000650 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8) EU-0010966 1684-40-8 (hydrochloride) KBio2_000896 5,6,7,8-tetrahydroacridin-9-amine LS-1191 9-Acridinamine, 1,2,3,4-tetrahydro-(9CI) NCGC00015054-06 AB00053524 NCGC00024908-04 Acridine, 9-amino-1,2,3,4-tetrahydro- PDSP2_000328 Tacrinum Tocris-0965 Z56790573 BPBio1_000371 SPBio_001823 C01453 ST083243 Cognex DSSTox_CID_17272 1,2,3,4-tetrahydro-acridin-9-yl-amine GTPL6687 2aow KBio3_002518 5-Amino-6,7,8,9-tetrahydroacridine (European) NCGC00015054-01 9-amino-1,2,3,4-tetrahydroacridine (THA) NCGC00015054-09 AB00053524_19 NCIOpen2_003667 AKOS000277493 Prestwick2_000329 Tenakrin Tox21_302277 Tacrinal Romotal BRD-K81473089-003-15-4 Spectrum3_001709 CCG-204132 Tacrin D08555 1,2,3,4-tetra -hydro-9-acridinamine DTXSID1037272 1,2,3,4-tetrahydroacridin-9-amine dihydrochloride KB-216200 4CH-007616 Lopac-A-3773 9-Acridinamine, 1,2,3,4-tetrahydro- NCGC00015054-04 9-THA NCGC00024908-01 AC1Q51C5 Oprea1_008681 BBL001044 Tacrine (INN) Tetrahydroaminocrin VZ20338 BDBM8961 SBI-0050025.P003 BSPBio_003298 Spectrum_000416 CHEMBL95 DB00382 1,2,3,4-Tetrahydro-9-acridineamine FT-0083001 1acj KBio2_003464 5,6,7,8-tetrahydroacridine-9-ylamine MCULE-3628803328 9-Acridinamine,1,2,3,4-tetrahydro- NCGC00015054-07 AB00053524-17 NCGC00024908-05 Acridine, 9-aminotetrahydro- Prestwick0_000329 Tacrinum [INN-Latin] Tox21_110073 ZINC19014866 [ Show all ]
Inchi Key	YLJREFDVOIBQDA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
PubChem CID	1935
ChEMBL	CHEMBL95
IUPHAR	6687
BindingDB	8961
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2100.0 nM	PMID1552502	BindingDB,IUPHAR,ChEMBL
Ki	220.0 nM	PMID1507203	BindingDB,ChEMBL

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