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GLASS

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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	Tacrine
Molecular formula	C13H14N2
IUPAC name	1,2,3,4-tetrahydroacridin-9-amine
Molecular weight	198.269
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.7
Synonyms	Tacrinal 2aox KBioGR_001337 Tenakrin NCGC00015054-02 Tox21_302277 9-Amino-1,2,3,4-Tetrahydroacridine Hydrate Hydrochloride Hydrate NCGC00015054-10 AB0126098 NE25597 ANW-46208 Prestwick3_000329 BRD-K81473089-003-03-0 SPBio_002258 C13H14N2 ST24026722 Cognex (TN) DSSTox_GSID_37272 1,2,3,4-Tetrahydro-acridin-9-ylamine HMS2089F19 KBio1_000936 Tacrine (INN) 4VX7YNB537 Lopac0_000036 Tetrahydroaminocrin 9-Acridinamine, 1,2,3,4-tetrahydro- (9CI) NCGC00015054-05 VZ20338 A18628 NCGC00024908-03 Acridine, 1,2,3,4-tetrahydro-9-amino- PDSP1_000330 BCP03564 Romotal (Salt/Mix) BRN 0147610 Spectrum4_000819 CHEBI:45980 Tacrina D0E6YQ 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE EINECS 206-291-2 1,2,3,4-Tetrahydroaminoacridine 1mx1 KBio2_006032 Tacrinum [INN-Latin] 5-Amino-6,7,8,9-tetrahydroacridine MolPort-000-881-472 Tox21_110073 9-amino-1,2,3,4-tetrahydroacridine NCGC00015054-08 ZINC19014866 AB00053524_18 NCGC00255540-01 AE-641/00604043 Prestwick1_000329 BIDD:GT0090 SCHEMBL2828 C-110 SR-01000075593-13 cid_1935 DivK1c_000936 1,2,3,4-Tetrahydro-9-aminoacridine FT-0631953 Tacrinal (TN) 321-64-2 KBioSS_000896 Tetrahydroaminacrine NCGC00015054-03 Tracine 9-AMINOTETRAHYDROACRIDINE NCGC00015054-12 AC1L1CK0 NINDS_000936 BAS 00232275 R9947 BRD-K81473089-003-04-8 Spectrum2_001812 CAS-321-64-2 STK101308 CS 12602 DSSTox_RID_79318 1,2,3,4-tetrahydroacridin-9-amine IDI1_000936 KBio2_000896 Tacrine [INN:BAN] 5,6,7,8-tetrahydroacridin-9-amine LS-1191 Tetrahydroaminocrine 9-Acridinamine, 1,2,3,4-tetrahydro-(9CI) NCGC00015054-06 YLJREFDVOIBQDA-UHFFFAOYSA-N AB00053524 NCGC00024908-04 Acridine, 9-amino-1,2,3,4-tetrahydro- PDSP2_000328 BCP9000019 SBB003560 BSPBio_000337 Spectrum5_001402 DB-000650 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8) EU-0010966 1684-40-8 (hydrochloride) Tacrina [INN-Spanish] 2aow KBio3_002518 TC-134953 5-Amino-6,7,8,9-tetrahydroacridine (European) NCGC00015054-01 Tox21_110073_1 9-amino-1,2,3,4-tetrahydroacridine (THA) NCGC00015054-09 AB00053524_19 NCIOpen2_003667 AKOS000277493 Prestwick2_000329 BPBio1_000371 SPBio_001823 C01453 ST083243 Cognex DSSTox_CID_17272 1,2,3,4-tetrahydro-acridin-9-yl-amine GTPL6687 KB-216200 4CH-007616 Lopac-A-3773 Tetrahydroaminoacridine 9-Acridinamine, 1,2,3,4-tetrahydro- NCGC00015054-04 UNII-4VX7YNB537 9-THA NCGC00024908-01 AC1Q51C5 Oprea1_008681 BBL001044 Romotal BRD-K81473089-003-15-4 Spectrum3_001709 CCG-204132 Tacrin D08555 1,2,3,4-tetra -hydro-9-acridinamine DTXSID1037272 1,2,3,4-tetrahydroacridin-9-amine dihydrochloride KBio2_003464 Tacrinum 5,6,7,8-tetrahydroacridine-9-ylamine MCULE-3628803328 Tocris-0965 9-Acridinamine,1,2,3,4-tetrahydro- NCGC00015054-07 Z56790573 AB00053524-17 NCGC00024908-05 Acridine, 9-aminotetrahydro- Prestwick0_000329 BDBM8961 SBI-0050025.P003 BSPBio_003298 Spectrum_000416 CHEMBL95 DB00382 1,2,3,4-Tetrahydro-9-acridineamine FT-0083001 1acj [ Show all ]
Inchi Key	YLJREFDVOIBQDA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
PubChem CID	1935
ChEMBL	CHEMBL95
IUPHAR	6687
BindingDB	8961
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	92470.0 nM	N/A	BindingDB

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