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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CCR4 Antagonist
Molecular formula	C27H41N5O2
IUPAC name	N-cycloheptyl-6,7-dimethoxy-2-(4-piperidin-1-ylpiperidin-1-yl)quinazolin-4-amine
Molecular weight	467.658
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	6.0
Synonyms	864289-85-0 compound 8ic [PMID: 19081254] SCHEMBL15280259 AKOS015994527 KS-00002WRL 2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine N-cycloheptyl-6,7-dimethoxy-2-(4-piperidin-1-ylpiperidin-1-yl)quinazolin-4-amine CTK8F8503 ZINC40379917 2-(1,4''-bipiperidin-1''-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine BDBM50243945 MolPort-020-313-384 CHEMBL508207 NCGC00370891-01 AF-0002 GTPL9478 2-(1,4''-Bipiperidine-1''-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine N-cycloheptyl-6,7-dimethoxy-2-(4-(piperidin-1-yl)piperidin-1-yl)quinazolin-4-amine [ Show all ]
Inchi Key	WYVBISCFCHREDA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H41N5O2/c1-33-24-18-22-23(19-25(24)34-2)29-27(30-26(22)28-20-10-6-3-4-7-11-20)32-16-12-21(13-17-32)31-14-8-5-9-15-31/h18-21H,3-17H2,1-2H3,(H,28,29,30)
PubChem CID	25141190
ChEMBL	CHEMBL508207
IUPHAR	9478
BindingDB	50243945
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
385724	C-C chemokine receptor type 4	P51679	CCR4	Homo sapiens (Human)	360
385725	C-C chemokine receptor type 4	P51680	Ccr4	Mus musculus (Mouse)	360

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