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| Name | estradiol |
|---|---|
| Molecular formula | C18H24O2 |
| IUPAC name | (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
| Molecular weight | 272.388 |
| Hydrogen bond acceptor | 2 |
| Hydrogen bond donor | 2 |
| XlogP | 4.0 |
| Synonyms | 17beta-Estradiol Ginedisc BIDD:PXR0065 NSC-9895 1g50 GynPolar [ Show all ]BPBio1_000532 Oestra-1,5(10)-triene-3,17.beta.-diol 3,17-beta-Dihydroxy-1,3,5(10)-oestratriene HMS2236H04 (+)-3,17beta-Estradiol Oestradiol-17beta and esters [Steroidal oestrogens] 3,17.beta.-Dihydroxy-1,3,5(10)-estratriene Innofem (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol Ovasterol 3,17beta-Dihydroxy-1,3,5(10)-estratriene KBio2_007405 003E693 Prestwick0_000441 4TI98Z838E Lamdiol progynon ACN-S003579 Menorest 17-.BETA.-Estradiol Sandrena Gel alpha-estradiol (obsolete) MLS001424022 17-decahydrocyclopenta[a]phenanthrene-3,17-diol AS-13729 NCGC00091544-06 17.beta.-OH-estradiol Femanest beta-Estradiol NCGC00091544-15 Estra-1,3,5(10)-triene-3,17-diol, (17beta)- Trial SAT cis-Oestradiol Estrace (TN) Vivelle (TN) CMC_11154 Zerella CS-1938 Estradiol [USP:INN:BAN] [3H]-Estrogen D-Oestradiol Estradiol-17.beta. Destradiol Estraldine Dihydroxyoestrin Estring (TN) DSSTox_GSID_20573 Estrofem Forte EINECS 200-023-8 SPBio_002421 Estasorb Syndiol C18H24O2 beta-Estradiol, analytical standard NCGC00179321-02 17beta-Oestra-1,3,5(10)-triene-3,17-diol GTPL1013 Bio1_000892 Oestergon 1qkt HMS1792E07 Oestradiol R 3,17-beta-Estradiol HMS3713I04 (17b)-Estra-1,3,5(10)-triene-3,17-diol Oestrogel 3,17.beta.-Dihydroxyestra-1,3,5-triene KBio2_000405 (8R,9S,13S,14S,17S)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol Ovocyclin 3,17beta-Dihydroxyestra-1,3,5-triene KBio3_002749 1,3,5-Estratriene-3,17-beta-diol Prestwick3_000441 873662-39-6 LP00503 125DP6010H Progynova (TN) Aerodiol Microdiol 17-beta-estradiol Sisare Gel Amnestrogen NCGC00091544-00 17.beta.-Estra-1,5(10)-triene-3,17-diol Evamist Bardiol NCGC00091544-10 17b-Estradiol Femogen CCRIS 280 Estra-1,3,5(10)-triene-3,17beta-diol UNII-125DP6010H Climara (TN) Estraderm MX VOXZDWNPVJITMN-ZBRFXRBCSA-N Compudose Estradiol complex ZINC13520815 D-3,17.beta.-Estradiol Estradiol, Pharmaceutical Secondary Standard; Certified Reference Material [3H]estradiol Estradiolo Dihydrofolliculin Estrasorb (TN) Diogyn Estroclim 50 E 2 Estrogel HBF Elestrin (TN) SR-01000075866-1 BRD-K18910433-001-04-4 Estra-1,3,5(10)-triene-3,17-beta-diol Tox21_111148 Follicyclin beta-Oestradiol NCGC00261188-01 17|A-Oestradiol Gynodiol Bio2_000843 Oestra-1,3,5(10)-triene-3,17b-diol 2j7x HMS2090E18 (+)-3,17.beta.-Estradiol Oestradiol-17beta 3,17-Epidihydroxyestratriene I06-2405 (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0(2),.0(1)(1),(1)]heptadeca-2,4,6-triene-5,14-diol Opera_ID_1688 3,17b-Dihydroxyestra-1,3,5(10)-triene KBio2_004837 .beta.-Estradiol Perlatanol 3,3,5(10)-triene KBioSS_000405 1,5-Estratriene-3,17.beta.-diol Profoliol AC-22346 Macrol 17 ?-Estradiol s1709 Alora MLS000758312 17-beta-OH-estradiol AOB5963 NCGC00091544-04 17.beta.-Oestra-1,5(10)-triene-3,17-diol Extrasorb BDBM17292 NCGC00091544-13 17beta oestradiol Estra-1,3,5(10)-triene-3,17-diol (17beta)-, homopolymer Tox21_500503 CHEMBL135 Estra-1,5(10)-triene-3,17.beta.-diol Vagifem (TN) Climara, Menostar Estraderm TTS 100 Z-4415 Corpagen Estradiol valerate (TN) [2,4,6,7-3H]-E2 D-3,17beta-Oestradiol Estradiol-17 beta delta-Oestradiol Estradiolum [INN] Dihydroxyesterin Estrifam Divigel (TN) Estrofem (TN) E0025 SMP1_000121 Epitope ID:136018 SR-01000721892-3 BSPBio_001065 NCGC00091544-16 17beta-estradiol (E2) Ginosedol Bio-E-Gel NSC9895 1jgl HMS1362E07 Oestradiol 3,17-beta-Dihydroxyestra-1,3,5(10)-triene HMS3261F07 (13S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-beta-diol Oestradiolum 3,17.beta.-Dihydroxy-1,3,5(10)-oestratriene Innofem (TN) (8''R'',9''S'',13''S'',14''S'',17''S'')-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[''a'']phenanthrene-3,17-diol Ovastevol 3,17beta-dihydroxyestra-1,3,5(10)-trien KBio3_000769 1,3,5(10)-estratriene-3,17b-diol Prestwick1_000441 50-28-2 LMST02010001 1050677-52-5 Progynon DH Activella (Salt/Mix) Menostar (TN) 17-beta SC-25771 alpha-Oestradiol MolPort-001-794-632 17-E Estrovite B-Estradiol NCGC00091544-07 17.beta.-OH-oestradiol Femestral beta-Estradiol, 98% Estra-1,3,5(10)-triene-3,17.beta.-diol Trocosone Climaderm Estraderm VIVELLE-DOT Combipatch (Salt/Mix) Estradiol (JAN/USP/INN) Zesteem D-3,17-beta-Estradiol Estradiol, .beta.- [3H]17beta-estradiol D00105 estradiol-17beta dihydro-Theelin Estrapak 50 Dimenformon Estring vaginal ring DSSTox_RID_75666 Estrogel Elestrim Spectrum5_002055 estra-1(10),2,4-triene-3,17-diol, (17beta)- Systen CAS-50-28-2 beta-Estradiol, BioReagent, powder, suitable for cell culture NCGC00254177-01 17beta-Oestradiol Gynergon Bio1_001381 Oestra-1,3,5(10)-triene-3,17-beta-diol 1qku HMS1990E07 Oestradiol-17-beta 3,17-beta-Oestradiol HSDB 3589 (17beta)-estra-1(10),2,4-triene-3,17-diol Oestroglandol 3,17.beta.-Dihydroxyoestra-1,3,5-triene KBio2_002269 (8S,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Ovocycline 3,17beta-Dihydroxyoestra-1,3,5-triene KBioGR_000405 1,3,5-Estratriene-3,17.beta.-diol Prestwick_207 AB0012866 LS-137 13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol Q-201503 AJ-64042 Minivelle 17-beta-Estradiol 100 microg/mL in Acetonitrile AN-6628 NCGC00091544-01 17.beta.-Estradiol EvaMist (TN) BC200811 NCGC00091544-11 17b-Oestradiol Fempatch CHEBI:16469 Estra-1,5(10)-triene-3,17-diol (17.beta.)- UNII-4TI98Z838E Climara Forte Estraderm TTS WLN: L E5 B666TTT&J E1 FQ OQ Compudose 200 Estradiol cypionate (TN) Zumenon D-3,17.beta.-Oestradiol Estradiol, United States Pharmacopeia (USP) Reference Standard [3H]]estradiol DB00783 Estradiolo [DCIT] Dihydromenformon Estrasorb Topical (TN) Diogynets Estrodiolum E 8875 SK-Estrogens Estrogens, esterified Encore SR-01000075866-4 BRD-K18910433-001-43-2 Estra-1,3,5(10)-triene-3,17-diol (17.beta.)- Tox21_202057 17beta-Estra-1,3,5(10)-triene-3,17-diol Gelestra BIDD:ER0125 Nordicol 1a52 Gynoestryl bmse000642 Oestra-1,3,5(10)-triene-3,17beta-diol 3,17-.beta.-Oestradiol HMS2096I04 (+)-3,17b-Estradiol Oestradiol-17beta and esters 3,17-Epidihydroxyoestratriene IDI1_002118 (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadeca-2,4,6-triene-5,14-diol Ovahormon 3,17b-Estradiol KBio2_005541 .beta.-Oestradiol Polyestradiol 3,3,5-triene KBioSS_002270 Profoliol B AC1L1L2K Menest 17 beta-Estradiol Sandrena 1 Alora (TN) MLS001076331 17-beta-OH-oestradiol Aquadiol NCGC00091544-05 17.beta.-Oestradiol Fem7 Benzogynestry NCGC00091544-14 Estra-1,3,5(10)-triene-3,17-diol(17b)- Tradelia cis-Estradiol Estrace Vivelle cMAP_000005 Estraderm TTS 50 Z1847670481 CPD000059126 Estradiol [USAN:INN] [3H]-estradiol D-Estradiol Estradiol-17-beta Dermestril Estradot Dihydroxyestrin Estring DSSTox_CID_573 Estrofem 2 EC 200-023-8 SMR000059126 Esclim SY017569 C00951 NCGC00179321-01 17beta-Estradiol solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material GTPL1012 Bio1_000403 Oesclim 1lhu HMS1569I04 Oestradiol Berco 3,17-beta-Dihydroxyoestra-1,3,5-triene HMS3403E07 (17?)-Estra-1,3,5(10)-triene-3,17-diol oestrodiol 3,17.beta.-Dihydroxyestra-1,3,5(10)-triene J10189 (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Ovociclina 3,17beta-Dihydroxyestra-1,3,5(10)-triene KBio3_000770 1,3,5,(10)-Estratrien-3,17.beta.-diol Prestwick2_000441 73459-61-7 Lopac0_000503 1206475-11-7 Progynon-DH Activella (TN) MFCD00003693 17-beta-Estra-1,3,5(10)-triene-3,17-diol SCHEMBL8049 Altrad NC00058 17.beta.-Estra-1,3,5(10)-triene-3,17-diol EU-0100503 B8B5AEF5-4957-49EB-A14F-444A8212C482 NCGC00091544-09 Femestrol beta-Estradiol, >=98% CCG-100808 Estra-1,3,5(10)-triene-3,17b-diol TX-004HR Climara Estraderm (TN) Vivelle-Dot (TN) component of Menrium Estradiol acetate (TN) Zesteen D-3,17-beta-Oestradiol Estradiol, meets USP testing specifications [3H]E2 D08QMX Estradiol-3,17beta Dihydrofollicular hormone Estrasorb Dimenformon prolongatum Estroclim DTXSID0020573 Estrogel (TN) Elestrin SR-01000075866 Estra-1,3,5(10)-triene -3,17beta-diol Theelin, dihydro- Femtran beta-Estradiol, powder, gamma-irradiated, suitable for cell culture NCGC00259606-01 17|A-estradiol;oestradiol;17|A-Oestradiol;|A-Estradiol Gynestrel Bio2_000363 Oestra-1,3,5(10)-triene-3,17.beta.-diol 2d06 HMS2051C17 Oestradiol-17.beta. 3,17-dihydroxy-delta(1,3,5-10)-estratriene HY-B0141 (17beta)-Estra-1,3,5(10)-triene-3,17-diol Oestrogynal 3,17.beta.-Estradiol KBio2_002973 .alpha.-Oestradiol Ovocylin 3,17beta-Estradiol KBioGR_002269 1,3,5-Estratriene-3,17beta-diol Primofol AB2000237 Macrodiol 13beta-Methyl-1,3,5(10)-gonatriene-3,17beta-ol S-21400 AKOS015896570 MLS000069494 17-beta-Oestra-1,3,5(10)-triene-3,17-diol Angeliq (TN) NCGC00091544-02 17.beta.-Oestra-1,3,5(10)-triene-3,17-diol Evorel BCP08579 NCGC00091544-12 17beta estradiol (E2) Tox21_300288 Estra-1,5(10)-triene-3,17-diol, (17.beta.)- Vagifem Climara Pro (Salt/Mix) Estraderm TTS (TN) Yuvvexy Compudose 365 ESTRADIOL HEMIHYDRATE [2,4,6,7-3H]-17beta-estradiol D-3,17beta-Estradiol Estradiol-17 alpha delta-Estradiol Estradiolum Dihydrotheelin Estreva Divigel Estrodiolum [INN-Latin] E(sub 2) SL-1100 Estropause Epiestriol 50 SR-01000721892 BSPBio_000482 Estra-1,3,5(10)-triene-3,17-diol (17beta)- |
| Inchi Key | VOXZDWNPVJITMN-ZBRFXRBCSA-N |
| Inchi ID | InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 |
| PubChem CID | 5757 |
| ChEMBL | CHEMBL135 |
| IUPHAR | 1013, 1012 |
| BindingDB | 17292 |
| DrugBank | DB00783 |
Structure |  |
| Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
You can:
| GLASS ID | Name | UniProt | Gene | Species | Length |
|---|---|---|---|---|---|
| 360593 | G-protein coupled bile acid receptor 1 | Q8TDU6 | GPBAR1 | Homo sapiens (Human) | 330 |
| 360592 | G-protein coupled estrogen receptor 1 | Q99527 | GPER1 | Homo sapiens (Human) | 375 |
| 360591 | Thyrotropin receptor | P16473 | TSHR | Homo sapiens (Human) | 764 |
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