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| Name | G-protein coupled bile acid receptor 1 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | GPBAR1 |
| Synonym | G-protein coupled receptor GPCR19 TGR5 BG37 G protein-coupled bile acid receptor 1 membrane-type receptor for bile acids [ Show all ] |
| Disease | Type 2 diabetes Metabolic disorders |
| Length | 330 |
| Amino acid sequence | MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN |
| UniProt | Q8TDU6 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | Q8TDU6 |
| 3D structure model | This predicted structure model is from GPCR-EXP Q8TDU6. |
| BioLiP | N/A |
| Therapeutic Target Database | T86273 |
| ChEMBL | CHEMBL5409 |
| IUPHAR | 37 |
| DrugBank | BE0005788 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 3103 |  CHEMBL571517 | C37H54O3 | 546.836 | 3 / 1 | 10.0 | No |
| 4981 |  CHEMBL3132966 | C20H19ClN4O2 | 382.848 | 4 / 0 | 3.9 | Yes |
| 6641 |  CHEMBL2336208 | C22H23FN4O2 | 394.45 | 5 / 0 | 3.4 | Yes |
| 9109 |  CHEMBL602273 | C20H17ClN2O4 | 384.816 | 5 / 0 | 3.9 | Yes |
| 9377 |  CHEMBL2435937 | C28H20F6N2O | 514.471 | 8 / 0 | 6.7 | No |
| 9741 |  BDBM50437875 | C29H26N2O4 | 466.537 | 5 / 1 | 4.6 | Yes |
| 9744 |  BDBM50437874 | C29H26N2O4 | 466.537 | 5 / 1 | 4.6 | Yes |
| 557581 |  CHEMBL1257491 | C22H19BrN2OS | 439.371 | 4 / 2 | 5.2 | No |
| 10408 |  CHEMBL2435922 | C23H19F7N2 | 456.408 | 9 / 1 | 6.1 | No |
| 442164 |  CHEMBL3329940 | C23H40O3 | 364.57 | 3 / 3 | 4.7 | Yes |
| 12074 |  CHEMBL598743 | C20H19ClN2O2 | 354.834 | 3 / 0 | 4.8 | Yes |
| 12529 |  CHEMBL1257611 | C23H21BrN2OS | 453.398 | 4 / 1 | 5.5 | No |
| 442179 |  CHEMBL3321842 | C20H16Cl2N4O | 399.275 | 4 / 1 | 5.3 | No |
| 13428 |  CHEMBL1257733 | C24H23BrN2O2S | 483.424 | 5 / 1 | 5.5 | No |
| 14938 |  CHEMBL2181246 | C21H16Cl2N2O2 | 399.271 | 3 / 0 | 5.4 | No |
| 15911 |  TAURODEOXYCHOLIC ACID | C26H45NO6S | 499.707 | 6 / 4 | 3.6 | Yes |
| 16598 |  Sulfolithocholic acid | C24H40O6S | 456.638 | 6 / 2 | 5.9 | No |
| 16835 |  CHEMBL2435916 | C26H17F7N2O2S | 554.483 | 11 / 1 | 6.5 | No |
| 17262 |  CHEMBL3290703 | C26H22N4O2 | 422.488 | 5 / 0 | 4.1 | Yes |
| 18425 |  CHEMBL3260994 | C26H45NaO6S | 508.69 | 6 / 2 | N/A | No |
| 19601 |  CHEMBL571497 | C32H52N2O3 | 512.779 | 3 / 3 | 6.9 | No |
| 19912 |  CHEMBL2181235 | C22H19Cl2N3O2 | 428.313 | 4 / 0 | 4.9 | Yes |
| 20330 |  CHEMBL3234580 | C26H29F3N6O3 | 530.552 | 11 / 2 | 3.5 | No |
| 20344 |  CHEMBL608867 | C20H18Cl2N2O2 | 389.276 | 3 / 0 | 5.6 | No |
| 20772 |  CHEMBL3290724 | C26H20ClN3O5 | 489.912 | 7 / 1 | 4.4 | Yes |
| 21447 |  CHEMBL590739 | C18H14Cl2N2O2 | 361.222 | 3 / 0 | 4.7 | Yes |
| 23086 |  CHEMBL592158 | C17H12Cl2N2O2 | 347.195 | 3 / 0 | 4.3 | Yes |
| 23963 |  cholic acid | C24H40O5 | 408.579 | 5 / 4 | 3.6 | Yes |
| 24074 |  TAUROCHENODEOXYCHOLIC ACID | C26H45NO6S | 499.707 | 6 / 4 | 3.6 | Yes |
| 24075 |  Tauroursodeoxycholic acid | C26H45NO6S | 499.707 | 6 / 4 | 3.6 | Yes |
| 24419 |  CHEMBL160902 | C23H38O3 | 362.554 | 3 / 2 | 5.9 | No |
| 24735 |  CHEMBL600833 | C19H16Cl2N2O2 | 375.249 | 3 / 0 | 5.1 | No |
| 24738 |  CHEMBL3234551 | C19H23FN4O | 342.418 | 5 / 1 | 2.9 | Yes |
| 27743 |  CHEMBL270703 | C24H42O4 | 394.596 | 4 / 4 | 3.8 | Yes |
| 28143 |  CHEMBL568374 | C32H50O4 | 498.748 | 4 / 1 | 8.3 | No |
| 29142 |  CHEMBL2407937 | C22H22N2O | 330.431 | 3 / 0 | 4.0 | Yes |
| 31654 |  CHEMBL2181256 | C22H18Cl2N4O2 | 441.312 | 5 / 0 | 4.8 | Yes |
| 32325 |  CHEMBL2181232 | C19H13Cl2N3O2S | 418.292 | 5 / 0 | 4.6 | Yes |
| 33017 |  CHEMBL2331652 | C20H24F2N6O2 | 418.449 | 8 / 2 | 1.1 | Yes |
| 33790 |  CHEMBL2181248 | C20H15Cl2N3O2 | 400.259 | 4 / 0 | 4.6 | Yes |
| 443012 |  CHEMBL3321847 | C18H14Cl2N4O2 | 389.236 | 5 / 1 | 3.7 | Yes |
| 35035 |  CHEMBL2336214 | C22H22Cl2N4O2 | 445.344 | 4 / 0 | 4.5 | Yes |
| 35136 |  CHEMBL2331646 | C22H29N5O2 | 395.507 | 5 / 2 | 2.5 | Yes |
| 35586 |  CHEMBL605986 | C19H17ClN2O2 | 340.807 | 3 / 0 | 4.4 | Yes |
| 35985 |  CHEMBL3290734 | C32H27ClN4O7 | 615.039 | 9 / 2 | 4.5 | No |
| 37470 |  CHEMBL2435927 | C20H13F7N2O2S | 478.385 | 11 / 1 | 4.8 | No |
| 38010 |  Etiocholanediol | C19H32O2 | 292.463 | 2 / 2 | 4.2 | Yes |
| 38011 |  Hombreol | C19H32O2 | 292.463 | 2 / 2 | 4.2 | Yes |
| 38339 |  CHEMBL599127 | C21H21ClN2O2 | 368.861 | 3 / 0 | 5.2 | No |
| 38458 |  CHEMBL612138 | C19H17ClN2O3 | 356.806 | 4 / 0 | 4.0 | Yes |
| 39241 |  CHEMBL605367 | C20H18Cl2N2O2 | 389.276 | 3 / 0 | 5.5 | No |
| 40042 |  CHEMBL604520 | C18H13Cl3N2O2 | 395.664 | 3 / 0 | 5.3 | No |
| 40585 |  CHEMBL2435929 | C25H20F7N3 | 495.445 | 10 / 0 | 6.6 | No |
| 558518 |  SCHEMBL10240963 | C24H24N2O3 | 388.467 | 5 / 2 | 4.4 | Yes |
| 41891 |  CHEMBL604524 | C21H21ClN2O2 | 368.861 | 3 / 0 | 5.4 | No |
| 42868 |  CHEMBL2336213 | C22H22Cl2N4O2 | 445.344 | 4 / 0 | 4.5 | Yes |
| 43600 |  CHEMBL3132972 | C18H16F3N5O2 | 391.354 | 8 / 0 | 2.5 | Yes |
| 45858 |  CHEMBL602892 | C19H17ClN2O2 | 340.807 | 3 / 0 | 4.4 | Yes |
| 443476 |  CHEMBL3321848 | C21H20Cl2N2O2 | 403.303 | 2 / 0 | 4.5 | Yes |
| 46477 |  CHEMBL1257380 | C23H18BrF3N2OS | 507.369 | 7 / 1 | 6.7 | No |
| 49463 |  CHEMBL3138092 | C33H49NO4 | 523.758 | 4 / 3 | 7.3 | No |
| 49464 |  CHEMBL212641 | C33H49NO4 | 523.758 | 4 / 3 | 7.3 | No |
| 50785 |  CHEMBL567770 | C31H50O3 | 470.738 | 3 / 1 | 8.7 | No |
| 52760 |  CHEMBL2336221 | C21H23N5O2 | 377.448 | 5 / 0 | 2.2 | Yes |
| 52824 |  CHEMBL2331654 | C20H21F3N4O4 | 438.407 | 9 / 1 | 2.5 | Yes |
| 54671 |  CHEMBL601218 | C19H14Cl2N2O2 | 373.233 | 3 / 0 | 4.7 | Yes |
| 54720 |  Prasterone sulfate | C19H28O5S | 368.488 | 5 / 1 | 2.8 | Yes |
| 443924 |  CHEMBL3421893 | C28H27Cl2N3O4 | 540.441 | 6 / 0 | 5.6 | No |
| 57100 |  CHEMBL1258424 | C23H21BrN2OS | 453.398 | 4 / 1 | 5.5 | No |
| 58670 |  CHEMBL2435945 | C27H20F6N2O2 | 518.459 | 9 / 0 | 6.5 | No |
| 58696 |  CHEMBL1258530 | C23H21BrN2OS | 453.398 | 4 / 1 | 5.6 | No |
| 58861 |  CHEMBL2435938 | C28H19ClF6N2O | 548.913 | 8 / 0 | 7.3 | No |
| 59058 |  Murideoxycholic acid | C24H40O4 | 392.58 | 4 / 3 | 4.9 | Yes |
| 59059 |  HYODEOXYCHOLIC ACID | C24H40O4 | 392.58 | 4 / 3 | 4.9 | Yes |
| 61101 |  CHEMBL2181255 | C22H18Cl2N4O2 | 441.312 | 5 / 0 | 4.9 | Yes |
| 63212 |  CHEMBL2336224 | C22H22Cl2N4O2 | 445.344 | 4 / 0 | 4.6 | Yes |
| 63921 |  CHEMBL601440 | C18H14ClFN2O2 | 344.77 | 4 / 0 | 4.2 | Yes |
| 444237 |  CHEMBL3421894 | C26H23Cl2N3O4 | 512.387 | 6 / 1 | 4.9 | No |
| 444242 |  CHEMBL3401351 | C25H42O3 | 390.608 | 3 / 2 | 6.8 | No |
| 65470 |  CHEMBL600827 | C18H14BrClN2O2 | 405.676 | 3 / 0 | 4.8 | Yes |
| 444289 |  BAR501 | C26H46O3 | 406.651 | 3 / 3 | 5.9 | No |
| 66694 |  CHEMBL2336216 | C23H23F3N4O2 | 444.458 | 7 / 0 | 4.1 | Yes |
| 67339 |  CHEMBL2181254 | C22H20Cl2N4O2 | 443.328 | 5 / 0 | 5.0 | Yes |
| 67412 |  CHEMBL3132970 | C20H18F3N3O3 | 405.377 | 8 / 0 | 3.7 | Yes |
| 444396 |  CHEMBL3421903 | C66H74Cl4N8O12 | 1313.16 | 16 / 2 | 8.1 | No |
| 69056 |  CHEMBL2435921 | C22H17F7N2 | 442.381 | 9 / 1 | 5.6 | No |
| 69508 |  CHEMBL1257259 | C22H18BrClN2S | 457.814 | 3 / 1 | 6.2 | No |
| 70107 |  CHEMBL3290733 | C33H31ClN4O6 | 615.083 | 8 / 1 | 5.3 | No |
| 70447 |  CHEMBL2181244 | C19H15Cl2N3O3 | 404.247 | 5 / 0 | 4.3 | Yes |
| 72456 |  CHEMBL600021 | C19H16Cl2N2O2 | 375.249 | 3 / 0 | 5.1 | No |
| 72464 |  CHEMBL601441 | C18H14Cl2N2O2 | 361.222 | 3 / 0 | 4.7 | Yes |
| 75139 |  CHEMBL272041 | C26H42O4 | 418.618 | 4 / 1 | 6.8 | No |
| 75414 |  CHEMBL1258877 | C24H22BrN3O2 | 464.363 | 5 / 1 | 5.0 | Yes |
| 75739 |  CHEMBL3290726 | C28H24ClN3O5 | 517.966 | 7 / 1 | 4.6 | No |
| 76657 |  CHEMBL2435915 | C20H12ClF7N2O2S | 512.827 | 11 / 1 | 5.8 | No |
| 77842 |  CHEMBL2181251 | C20H15Cl2N3O2 | 400.259 | 4 / 0 | 4.7 | Yes |
| 444872 |  CHEMBL3421896 | C30H30Cl2N4O5 | 597.493 | 7 / 1 | 4.9 | No |
| 80130 |  CHEMBL2062554 | C26H43NaO5 | 458.615 | 5 / 3 | N/A | N/A |
| 80131 |  CHEMBL2062553 | C26H43NaO5 | 458.615 | 5 / 3 | N/A | N/A |
| 80797 |  CHEMBL3290707 | C25H21N3O3 | 411.461 | 5 / 0 | 4.3 | Yes |
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