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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled bile acid receptor 1
Species	Homo sapiens (Human)
Gene	GPBAR1
Synonym	G-protein coupled receptor GPCR19 TGR5 BG37 G protein-coupled bile acid receptor 1 membrane-type receptor for bile acids M-BAR hGPCR19 hBG37 GPCR19 GPBAR1 GPBA receptor GPR131 [ Show all ]
Disease	Type 2 diabetes Metabolic disorders
Length	330
Amino acid sequence	MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
UniProt	Q8TDU6
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDU6
3D structure model	This predicted structure model is from GPCR-EXP Q8TDU6.
BioLiP	N/A
Therapeutic Target Database	T86273
ChEMBL	CHEMBL5409
IUPHAR	37
DrugBank	BE0005788

Ligand

Name	Murideoxycholic acid
Molecular formula	C24H40O4
IUPAC name	(4R)-4-[(3R,5R,6R,8S,9S,10R,13R,14S,17R)-3,6-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Molecular weight	392.58
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	4.9
Synonyms	3a,6b-Dihydroxy-5b-cholanate 3alpha,6beta-dihydroxycholan-24-oic acid C15515 Murocholic acid 3a,6b-Dihydroxy-5b-cholanoic acid 6b-Hydroxylithocholic acid CHEMBL272620 3a,6b-Dihydroxy-5b-cholan-24-oate 3alpha,6beta-Dihydroxy-5beta-cholan-24-oic Acid AC1NR33X 3a,6b-Dihydroxy-5b-cholanic acid CHEBI:52030 SCHEMBL236847 3a,6b-Dihydroxycholanoate 6beta-Hydroxylithocholate LMST04010025 3a,6b-Dihydroxy-5b-cholan-24-oic acid 3alpha,6beta-Dihydroxy-5beta-cholanic acid BDBM50375598 Murocholate 3a,6b-Dihydroxy-5b-cholanoate 6b-Hydroxylithocholate (4R)-4-[(3R,5R,6R,8S,9S,10R,13R,14S,17R)-3,6-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid 3a,6b-Dihydroxycholanoic acid 6beta-hydroxylithocholic acid Murideoxycholate [ Show all ]
Inchi Key	DGABKXLVXPYZII-PLYQRAMGSA-N
Inchi ID	InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21-,23-,24-/m1/s1
PubChem CID	5283821
ChEMBL	CHEMBL272620
IUPHAR	N/A
BindingDB	50375598
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	4890.0 nM	PMID18307294	BindingDB,ChEMBL
Efficacy	94.4 %	PMID18307294	ChEMBL

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